Interaction of Macromolecular Drugs with Receptors
Leonardo da Vinci, in that part of his writings which is currently known as Hammer Codex, put forward a hypothesis to explain the circulation of water in the world. Although this renaisance scientist correctly specified all the elements involved, he erroneously rejected rain as a serious factor and suggested that water circulation was due to spontaneous seepage of water from the seas through underground porous rocks to the mountains, from where the rivers flow again. Obviously, we often overestimate the adverse effects of an erroneous hypothesis; such a hypothesis may be temporarily useful and definitely does not limit more rational analyses by others. Appreciation of these aspects of research suitably prepares a reader for the present chapter. Experimental observations described here are hopefully as solid as the rocks, rivers, and rain of da Vinci. We cannot be as certain about the correctness of the hypotheses explaining the observations, but at least the hypotheses are guaranteed harmless to anyone who finds a better explanation.
KeywordsMembrane Preparation Glycidyl Ether Opiate Receptor Steric Strain Macromolecular Drug
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