Skip to main content

Cell Membrane Molecules on Neoplastic Cells: Their Role in Malignant Cell Transformation and Dissemination

  • Chapter
  • 158 Accesses

Part of the book series: NATO ASI Series ((NSSA,volume 113))

Abstract

Malignant, neoplastic cell populations are characterized by their autonomous growth, invasiveness and metastatic activity. These features, like normal cellular activities, are all dependant on the interaction between the cells and their microenvironment. The cell membrane therefore constitutes a crucial biological structure in neoplastic cell behaviour.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. J.R. Gabin, P. Gordon, J. Ruth, J.A. Archer and D.N. Buell, Characteristics of the human lymphocytes insulin receptor, J. Biol. Chem. 248:2202 (1973).

    Google Scholar 

  2. S. Jacobs and P. Cuatrecasas, Insulin receptor structure and function, Endocrine Rev. 2:251 (1981).

    Article  CAS  Google Scholar 

  3. H.O. McDevitt, Current concepts in immunology: Regulation of the immune response by the major histocombatibility system, N. Engl. J. Med. 303:1514 (1980).

    Article  CAS  Google Scholar 

  4. L. Hood, M. Steinmetz and B. Mulissen, Genes of the major histocompatibility complex of the mouse, Ann. Rev. Immunol. 1:529 (1983).

    Article  CAS  Google Scholar 

  5. J. Lotem and L. Sachs, Regulation of normal differentiation in mouse and human myeloid leukemia cells by phorbol ester and the mechanism of tumor promotion, Carcinog. Compr. Surv. 7:385 (1982).

    CAS  Google Scholar 

  6. R.W. Schroff, K.A. Foon, R.J. Billing and J.L. Fahey, Immunologie classification by lymphocytic leukemias based on monoclonal antibody-defined cell surface antigens, Blood 59:207 (1982).

    CAS  Google Scholar 

  7. A.J. McMichal and J.W. Fabre (eds), “Monoclonal antibodies in clinical medicine.” Academic Press, London (1982).

    Google Scholar 

  8. M.S. Mitchell and H.F. Oettgen, Hybridomas in cancer diagnosis and treatment, Prog. Cancer Res. Ther. 21:1 (1982).

    Google Scholar 

  9. R.J. Cohen and H.N. Eisen, Hypothesis: Interaction of macromolecules on cell membranes and restriction of T-cell specificity by products of the major histocompatibility comples, Cell Immunol. 32:1 (1977).

    Article  CAS  Google Scholar 

  10. M. Simonsen and L. Olsson, Possible roles of compound receptors in the immune system, Ann. Immunol. 134D:85 (1983).

    CAS  Google Scholar 

  11. M. Simonsen, C. Skjødt and M. Crone, Compound receptors in the cell membrane: Ruminations from the borderland of immunology and physiology, Prog. Allergy 36:151 (1985)

    CAS  Google Scholar 

  12. L. Olsson, Human monoclonal antibodies in experimental cancer research, J. Natl. Cancer Inst., in press.

    Google Scholar 

  13. L. Old, Cancer immunology: The search for specificity, Cancer Res. 41:361 (1981).

    CAS  Google Scholar 

  14. S. Ohno, The original function of MHC antigen as the general plasma membrane anchorage site of organogenesis-directing proteins. Immunol. Rev., 33:59 (1977).

    Article  CAS  Google Scholar 

  15. V. Ginsburg, P. Fredman and J. Magnani, Cancer associated carbohydrated antigens detected by monoclonal antibodies, Contrib. Oncol. 19:51 (1984).

    Google Scholar 

  16. S. Hakamori and R. Kannagi, Glycosphingolipids as tumor-associated and differentiation markers, J. Natl. Cancer Inst. 71:231 (1983).

    Google Scholar 

  17. T. Feizi, Demonstration and glycolipids are onco-developmental antigens, Nature 314:53 (1985).

    Article  CAS  Google Scholar 

  18. P.C. Nowell, The clonal evolution to tumor cell populations, Science 194:23 (1976).

    Article  CAS  Google Scholar 

  19. G. Poste and I.J. Fidler, The pathogenesis of cancer metastasis, Nature 283:139 (1980).

    Article  CAS  Google Scholar 

  20. G.H. Heppner, Tumor heterogeneity, Cancer Res. 44:2259 (1984).

    CAS  Google Scholar 

  21. L. Olsson, Phenotypic diversity in leukemia cell population, Cancer Metastasis Rev. 2:153 (1983).

    Article  CAS  Google Scholar 

  22. A.D. Riggs and P.A. Jones, 5-methylcytosine, gene regulation and cancer, Adv. Cancer Res. 40:1 (1983).

    Article  CAS  Google Scholar 

  23. P.A. Jones, Altering gene expression with 5-azacytidine, Cell 40:485 (1985).

    Article  CAS  Google Scholar 

  24. L. Olsson, C. Due and M. Diamant, Treatment of human cell lines with non-mutagenic, non-toxic doses of 5-azacytidine may result in profound alterations in clonogenicity and growth rate, J. Cell. Biol. 100:108 (1985).

    Article  Google Scholar 

  25. L. Ossowski and E. Reich, Changes in malignant phenotype of a human carcinoma conditioned by growth environment, Cell 33:323 (1983).

    Article  CAS  Google Scholar 

  26. C. Honsik, M. Diamant and L. Olsson, Generation of stable cellular phenotypes in a human malignant cell line conditioned by alterations in the cellular microenvironment, Submitted.

    Google Scholar 

  27. L. Chatenaud and J.F. Bach, Antigenic modulation — a major mechanism of antibody action, Immunol. Today 5:20 (1984).

    Google Scholar 

  28. M.D. Waterfield, G.T. Scarce and N. Whittle, Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of Simian sarcoma virus, Nature 304:35 (1983).

    Article  CAS  Google Scholar 

  29. R.F. Doolittle, M.W. Hunkapilar and L. Hood, Simian sarcoma virus onc-gene, v-sis, is derived from the gene (or genes) encoding a platelet-derived growth factor, Science 221:275 (1983).

    Article  CAS  Google Scholar 

  30. T. Hunter, Oncogenes and proto-oncogenes: How do they differ? J. Natl. Cancer Inst. 73:773 (1984).

    CAS  Google Scholar 

  31. T. Burgess, Growth factors and oncogenes, Immunol. Today 6:107 (1985).

    Article  CAS  Google Scholar 

  32. A. Ullrich, L. Cousseus and J.S. Hayflink, Human epidermal growth factor receptor. DNA sequence and oberrant expression of the amplified gene in A431 epidernoid carcinoma cells, Nature 309:18 (1984).

    Article  Google Scholar 

  33. L. Olsson and J. Forchhammer, Induction of the metastatic phenotype in a mouse tumor model by 5-azacytidine and characterization of an antigen associated with metastatic activity, Proc. Natl. Acad. Sci USA 81:7897 (1984).

    Article  Google Scholar 

  34. I.R. Hart, Molecular basis of tumour spreads, Nature 315:274 (1985).

    Article  CAS  Google Scholar 

  35. R.A. Miller, D.G. Maloney, R. Warnke and R. Levy, Treatment of B-cell lymphoma with monoclonal anti-idiotype antibody, N. Engl. J. Med. 306:517 (1982).

    Article  CAS  Google Scholar 

  36. R. Levy and R.A. Miller, Biological and clinical implications of lymphocyte hybridomas: Tumor therapy with monoclonal antibodies, Ann. Rev. Med. 34:107 (1983).

    Article  CAS  Google Scholar 

  37. H. Koprowski, D. Herlyn and M. Lubeck, Human anti-idiotype antibodies in cancer patients: Is the modulation of the immune response beneficial for the patient?, Proc. Natl. Acad. Sci. USA 81:216 (1984).

    Article  CAS  Google Scholar 

  38. G.T. Nepom, U.T. Nelson and S.L. Holbeck, Induction of immunity to a human tumor marker by in vivo administration of anti-idiotypic antibodies in mice, Proc. Natl. Acad. Sci USA 81:2864 (1984).

    Article  CAS  Google Scholar 

  39. L. Olsson, H.R. Sørensen and O. Behnke, Intratumoral phenotypic diversity of cloned human lung tumor cell lines and consequences for analysis with monoclonal antibodies, Cancer 54:1757 (1984).

    Article  CAS  Google Scholar 

  40. L Olsson, O. Behnke and H.R. Sørensen, Modulatory effects of 5-azacytidine, phorbol ester, and retinoid acid on the malignant phenotype of human lung cancer cells, Int. J. Cancer 35:189 (1985).

    Article  CAS  Google Scholar 

  41. D. Pettijohn, C. Due and E. Rønne, Specific glycoproteins released by human squamous lung carcinoma cells: Characterization and diagnostic applications, J. Natl. Cancer Inst., in press.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1986 Plenum Press, New York

About this chapter

Cite this chapter

Olsson, L., Due, C. (1986). Cell Membrane Molecules on Neoplastic Cells: Their Role in Malignant Cell Transformation and Dissemination. In: Gregoriadis, G., Senior, J., Poste, G. (eds) Targeting of Drugs With Synthetic Systems. NATO ASI Series, vol 113. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5185-6_2

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-5185-6_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5187-0

  • Online ISBN: 978-1-4684-5185-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics