Liposomes In Vivo: A Relationship between Stability and Clearance?

  • Gregory Gregoriadis
  • Judith Senior
Part of the NATO ASI Series book series (NSSA, volume 113)


Quantitative retention of entrapped drugs by liposomes en route to their destination is usually an essential prerequisite for the successful use of the carrier. Furthermore, for cell targets other than those of the reticuloendothelial system (RES) (by which liposomes are taken up rapidly), there is a need for prolonging the presence of liposomes in the circulation.1,2 Recent developments in this laboratory show that both liposomal permeability to entrapped solutes in the presence of blood and clearance from the circulation can be controlled by simple adjustments of the structural characteristics of the vesicles.


Small Unilamellar Vesicle Solute Retention Unilamellar Liposome Latex Microsphere Nucleopore Filter 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Gregory Gregoriadis
    • 1
  • Judith Senior
    • 1
  1. 1.Medical Research Council Group, Academic Department of MedicineRoyal Free Hospital School of MedicineLondonUK

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