Liposomes In Vivo: A Relationship between Stability and Clearance?
Quantitative retention of entrapped drugs by liposomes en route to their destination is usually an essential prerequisite for the successful use of the carrier. Furthermore, for cell targets other than those of the reticuloendothelial system (RES) (by which liposomes are taken up rapidly), there is a need for prolonging the presence of liposomes in the circulation.1,2 Recent developments in this laboratory show that both liposomal permeability to entrapped solutes in the presence of blood and clearance from the circulation can be controlled by simple adjustments of the structural characteristics of the vesicles.
KeywordsSmall Unilamellar Vesicle Solute Retention Unilamellar Liposome Latex Microsphere Nucleopore Filter
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