The concept of drug-carriers has been developed as an alternative to a tissue distribution dependant on the molecular action of the drug. Classically, an intravenously administered drug is distributed in the body as a function of intrinsic properties of the molecule. A pharmacologically active concentration is reached in the diseased tissue at the expense of massive distribution in the rest of the body. For many drugs, e.g. cytostatics or antileishmaniasis agents, this poor specificity raises a toxicological problem which represents a real obstacle to an effective therapy. An improvement to this situation could be brought about by the use of a carrier directing the drug to the target tissue.
KeywordsAnionic Polymerization Mouse Peritoneal Macrophage Frit Glass Filter Circulation Tube Colloidal Drug Delivery System
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