Glutathione Transferases and Carcinogenesis

  • Brian Ketterer
  • David J. Meyer
  • Brian Coles
  • John B. Taylor
  • Sally Pemble
Part of the Basic Life Sciences book series (BLSC, volume 39)


Carcinogenesis has been regarded as being divisible into at least 3 major phases: (a) initiation, a largely irreversible process which has been compared to mutation; (b) promotion, a process during which cells undergo phenotypic changes, some of which are referred to as preneoplastic, and a proportion of which attain autonomy when they can be regarded as neoplastic; and (c) progression, a period of continuing phenotypic diversification during which a selection is made of those cells that possess autonomy and advantages over the host tissue. The result is increasing malignancy and, without intervention, the death of the host (22). The selective forces involved in carcinogenesis are reminiscent of those proposed for evolution, but in the case of cancer it is evolution within a lifetime and the result is biological chaos.


Glutathione Transferase Ethacrynic Acid Cumene Hydroperoxide Cysteinyl Residue Spermatogenic Tissue 


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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Brian Ketterer
    • 1
  • David J. Meyer
    • 1
  • Brian Coles
    • 1
  • John B. Taylor
    • 1
  • Sally Pemble
    • 1
  1. 1.Middlesex Hospital Medical SchoolCourtauld Institute of BiochemistryLondonUK

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