Cytochromes P-450 and the Activation and Inactivation of Mutagens and Carcinogens

  • Henry W. Strobel
  • Wan-Fen Fang
  • Richard S. Takazawa
  • Daniel J. Stralka
  • S. N. Newaz
  • Gary P. Kurzban
  • David R. Nelson
  • R. Scott Beyer
Part of the Basic Life Sciences book series (BLSC, volume 39)


The activation and inactivation of a wide variety of endogenous and exogenous compounds, including alkanes, fatty acids, steroids, drugs, polycyclic hydrocarbons, carcinogens, and mutagens, are catalyzed by the cytochrome P-450-dependent drug metabolism system (5). This system is found in the endoplasmic reticulum of various mammalian tissues and organs, e.g., lung, small intestines, etc. (20, 24), but the greatest concentration and activity are in the liver (5). For this reason, many pioneering studies on the activation or inactivation of carcinogens, mutagens, and other drugs have been carried out using hepatic microsomes from various animal models. In turn, mammalian liver also was used in attempts to isolate, purify, and characterize components of the mixed-function oxidase system.


Liver Microsome None None Polycyclic Hydrocarbon NADPH Cytochrome Human Colon Tumor Cell 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Henry W. Strobel
    • 1
  • Wan-Fen Fang
    • 1
  • Richard S. Takazawa
    • 1
  • Daniel J. Stralka
    • 1
  • S. N. Newaz
    • 1
  • Gary P. Kurzban
    • 1
  • David R. Nelson
    • 1
  • R. Scott Beyer
    • 1
  1. 1.Department of Biochemistry and Molecular BiologyThe University of Texas Medical SchoolHoustonUSA

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