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Cytochromes P-450 and the Activation and Inactivation of Mutagens and Carcinogens

  • Chapter
Antimutagenesis and Anticarcinogenesis Mechanisms

Part of the book series: Basic Life Sciences ((BLSC,volume 39))

Abstract

The activation and inactivation of a wide variety of endogenous and exogenous compounds, including alkanes, fatty acids, steroids, drugs, polycyclic hydrocarbons, carcinogens, and mutagens, are catalyzed by the cytochrome P-450-dependent drug metabolism system (5). This system is found in the endoplasmic reticulum of various mammalian tissues and organs, e.g., lung, small intestines, etc. (20, 24), but the greatest concentration and activity are in the liver (5). For this reason, many pioneering studies on the activation or inactivation of carcinogens, mutagens, and other drugs have been carried out using hepatic microsomes from various animal models. In turn, mammalian liver also was used in attempts to isolate, purify, and characterize components of the mixed-function oxidase system.

Supported by Grant CA37148 from the National Cancer Institute and Grant Ag02081 from the National Institute of Aging, DHHS.

Recipient of a Rosalie B. Hite Fellowship for Cancer Research.

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Author information

Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, Texas, USA, 77225

    Henry W. Strobel, Wan-Fen Fang, Richard S. Takazawa, Daniel J. Stralka, S. N. Newaz, Gary P. Kurzban, David R. Nelson & R. Scott Beyer

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  1. Henry W. Strobel
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Editor information

Editors and Affiliations

  1. University of Kansas, Lawrence, Kansas, USA

    Delbert M. Shankel

  2. Johns Hopkins University, Baltimore, Maryland, USA

    Philip E. Hartman

  3. National Institute of Genetics, Mishima, Japan

    Tsuneo Kada

  4. Council for Research Planning in Biological Sciences, Inc., Washington, D.C., USA

    Alexander Hollaender , Claire M. Wilson  & Gregory Kuny ,  & 

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© 1986 Plenum Press, New York

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Strobel, H.W. et al. (1986). Cytochromes P-450 and the Activation and Inactivation of Mutagens and Carcinogens. In: Shankel, D.M., Hartman, P.E., Kada, T., Hollaender, A., Wilson, C.M., Kuny, G. (eds) Antimutagenesis and Anticarcinogenesis Mechanisms. Basic Life Sciences, vol 39. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5182-5_5

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  • DOI: https://doi.org/10.1007/978-1-4684-5182-5_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5184-9

  • Online ISBN: 978-1-4684-5182-5

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