Introduction: Future Directions for Research in Antimutagenesis and Anticarcinogenesis

  • Elizabeth K. Weisburger
Part of the Basic Life Sciences book series (BLSC, volume 39)


The initial experiment demonstrating an anticarcinogenic effect, but under drastic conditions, was reported by Berenblum in 1929. Sulfur mustard treatment decreased the incidence of skin tumors in mice resulting from subsequent application of coal tar [Berenblum, I. (1929) J. Path. Bact. 32:425−434]. A biochemical explanation has not been provided for this phenomenon, but the mustard may have cross-linked the cellular DNA so that further attachment by the polycyclic aromatic hydrocarbons in the tar was prevented.


Polycyclic Aromatic Hydrocarbon Skin Tumor Endocrine Organ Subsequent Application Sulfur Mustard 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Elizabeth K. Weisburger
    • 1
  1. 1.Division of Cancer EtiologyNational Cancer InstituteBethesdaUSA

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