Introduction: Future Directions for Research in Antimutagenesis and Anticarcinogenesis
The initial experiment demonstrating an anticarcinogenic effect, but under drastic conditions, was reported by Berenblum in 1929. Sulfur mustard treatment decreased the incidence of skin tumors in mice resulting from subsequent application of coal tar [Berenblum, I. (1929) J. Path. Bact. 32:425−434]. A biochemical explanation has not been provided for this phenomenon, but the mustard may have cross-linked the cellular DNA so that further attachment by the polycyclic aromatic hydrocarbons in the tar was prevented.