Anticarcinogenic and Other Protective Effects of Dithiolthiones
In this chapter we discuss a class of chemicals that protect against carcinogenesis, radiation, and injury by a variety of toxic agents. These compounds are dithiolthiones (Fig. 1). They are characterized by a pentacyclic ring, consisting of two adjacent sulfurs with a third sulfur attached to a carbon, and an aromatic ring attached to another carbon. As found in collaboration with Dr. Wattenberg, a single dose of a dithiolthione called oltipraz protects against the carcinogenic effects of benzo(α)pyrene (BP) in mice. When oltipraz was administered 24 hr before BP, the number of malignancies in the lung was reduced from 23.4 to 4.6, and the number in the forestomach from 5.1 to 2.8, This protection lasted for at least two days because, if oltipraz was administered 48 hr (instead of 24 hr) before BP, there was a similar reduction of tumors in both the lung and the forestomach.
KeywordsBiochemical Effect Glutathione Level Glutathione Transferase Cruciferous Vegetable Quinone Reductase
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