Abstract
Improvement in prevention and therapy of various types of cancers represents the major challenge in modern medicine. Surgery, chemotherapy, and radiotherapy result in temporary or sometimes complete remission only in a certain percentage of cancer patients. Immunotherapy, although promising, is still in an experimental stage. Increasingly, emphasis has therefore focused on the prevention of cancer formation. One of the ways to achieve this goal is to design and administer agents that modulate the process of carcinogenesis.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Ames, B.N. (1983) Dietary carcinogens and anticarcinogens. Science 221:1256–1264.
Baden, H.P., J.M. Parrington, J.D.A. Delhanty, and M.A. Pathak (1972) DNA synthesis in normal and xeroderma pigmentosum fibroblasts following treatment with 8-methoxypsoralen and long wave ultraviolet light. Biochim. Biophys. Acta 262:247–255.
Bendich, A., and S.S. Shapiro (1984) Effect of dietary ß-carotene on lymphocyte responses to mutagens. Fed. Proc. 41:2936.
Bensasson, R.V., E.J. Land, and C. Salet (1978) Triplet excited state of furocoumarins: Reaction with nucleic acid bases and amino acids, Photochem. Photobiol. 27:273–280.
Borenstein, B., and R.H. Bunnel (1966) Carotenoids: Properties, occurrence and utilization in foods. In Advances in Food Research, Vol. 15, G.O. Chichester, E.M. Mrak, and G.F. Stewart, eds. Academic Press, Inc., New York.
Burton, G.W., and K.U. Ingold (1984) 3-Carotene: An unusual type of lipid antioxidant. Science 224:569–573.
Cole, R.S. (1970) Light-induced cross-linking of DNA in the presence of a furocoumarin (psoralen). Studies with phage λ, Escherichia coli, and mouse leukemia cells. Biochim. Biophys. Acta 217:30–39.
Committee on Diet, Nutrition and Cancer; National Research Council (1982) Diet, Nutrition, and Cancer, National Academy Press, Washington, D.C.
Cutler, R.G. (1985) Antioxidants and longevity of mammalian species. In Molecular Biology of Aging, A.D. Woodhead, A.D. Blackett, and A. Hollaender, eds. Plenum Press, New York, pp. 15–73.
Deuel, H.J. (1957) The Lipids, Their Chemistry and Biochemistry, Vol. 3, Interscience Publishers, Inc., New York.
De Mol, N.J., G.M.J. Beijersbergen van Henegouwen, and B. Van Beele (1981) Singlet oxygen formation by sensitization of furocoumarins complexed with, or bound covalently to DNA. Photochem. Photobiol. 34: 661–666.
De Mol, N.J., G.M.J. Beijersbergen van Henegouwen, G.R. Mohn, B.W. Glickman, and P.M. van Kleef (1981) On the involvement of singlet oxygen in mutation induced by 8-methoxypsoralen and UVA irradiation in Escherichia coli K-12. Mutat. Res. 82:23–30.
De Mol, N.J., and G.M.J. Beijersbergen van Henegouwen (1981) Relation between some photobiological properties of furocoumarins and their extent of singlet oxygen production. Photochem. Photobiol. 33:815–819.
De Mol, N.J., and G.M.J. Beijersbergen van Henegouwen (1979) Formation of singlet molecular oxygen by 8-methoxypsoralen. Photochem. Photobiol. 30:331–335.
Fitzpatrick, T.B., M.A. Pathak, L.C. Harber, M. Seiji, and A. Kukita (1974) An introduction to the problem of normal and abnormal responses of man’s skin to solar radiation. In Sunlight and Man, M.A. Pathak, L.C. Harber, M. Seiji, and A. Kukita, eds. University of Tokyo Press, Tokyo, pp. 3–14.
Gilchrest, B., J. Parrish, L. Tannenbaum, H. Haynes, and T. Fitzpatrick (1976) Oral methoxsalen photochemotherapy of mycosis fungoides. Cancer (Philadelphia) 38:683–689.
Giles, Jr., A., W. Warner, and A. Kornhauser (1985) In vivo protective effect of 3-carotene against psoralen phototoxicity. Photochem. Photobiol. 41:661–666.
Granger, M., F. Toulme, and C. Helene (1982) Photodynamic inhibition Escherichia coli DNA polymerase I by 8-methoxypsoralen plus near ultraviolet irradiation. Photochem. Photobiol. 36:175–180.
Ivie, G.W., D.L. Holt, and M.C. Ivey (1981) Natural toxicants in human foods: Psoralens in raw and cooked parsnip root. Science 213:909–910.
Kornhauser, A., W.G. Wamer, and A.L. Giles Jr. (1982) Psoralen phototoxicity: Correlation with serum and epidermal 8-methoxypsoralen and 5-methoxypsoralen in the guinea pig. Science 217:733–735.
Kornhauser, A., W.G. Wamer, and A.L. Giles Jr. (1982) Difference in topical and systemic reactivity of psoralens: Determination of epidermal and serum levels. In Photobiologic, Toxicologic, and Pharmacologic Aspects of Psoralens (NCI Monograph 66), M.A. Pathak and J.K. Dunnick, eds. National Cancer Institute, pp. 97–101.
Kornhauser, A. (1980) Molecular aspects of phototoxicity. Ann. N.Y. Acad. Sci. 346:398–414.
Krinsky, N.I., and S.M. Deneke (1982) Interaction of oxygen and cxyradicals with carotenoids. J. Natl. Cancer Inst. 69:205–210.
Lamola, A.A., and W.E. Blumberg (1976) The effectiveness of B-carotene and phytoene as systemic sunscreens. In Proceedings of the 4th Annual Meeting of the American Society for Photobiology, Denver, Colorado, Abstract No. FAM-C4, p. 109.
Lerman, S., J. Megaw, and I. Willis (1980) The photoreactions of 8-methoxypsoralen with tryptophan and lens proteins. Photochem. Photobiol. 31:235–242.
Luo, R.F. (1978) Photobiological action of 8-methoxypsoralen to the respiratory response and lipid peroxide formation of mitochondria. Kurume Med. Assoc. J. 41:723–735.
McCord, J.M. (1985) Oxygen-derived free radicals in postischemic tissue injury. New Engl. J. Med. 312:159–163.
Mathews-Roth, M.M. (1984) Prophyrin photosensitization and carotenoid protection in mice: In vitro and in vivo studies. Photochem. Photobiol. 40:63–67.
Mathews-Roth, M.M. (1982) Antitumor activity of ß-carotene and canthaxanthin. Oncology 39:33–37.
Mathews-Roth, M.M. (1982) Effect of crocetin on experimental skin tumors in hairless mice. Oncology 39:362–364.
Mathews-Roth, M.M. (1981) Medical application and uses of carotenoids. In Carotenoid Chemistry and Biochemistry, G. Britton and T.W. Goodwin, eds. Pergamon Press, New York, pp. 297–307.
Mathews-Roth, M.M., D. Hummel, and C. Crean (1977) The carotenoid content of various organs of animals administered large amounts of beta-carotene. Nutr. Rep. Int. 16:419–423.
Mathews-Roth, M.M., T. Wilson, E. Fujimori, and N.I. Krinsky (1974) Carotenoid chromophore length and protection against photosensitization. Photochem. Photobiol. 19:217–222.
Mathews-Roth, M.M., M.A. Pathak, T.B. Fitzpatrick, L.C. Harber, and E.H. Kass (1974) 3-Carotene as an oral photoprotective agent in erythropoietic protoporphyria. J. Am Med. Assoc. 228:1004–1008.
Mathews, M. (1963) Studies on the localization, function and formation of the carotenoid pigments of a strain of Mycobacterium marinum. Photochem. Photobiol. 2:1–8.
Mathews, M.i and W.R. Sistrom (1959) Intracellular location of carotenoid pigments and some respiratory enzymes in S. lutea. J. Bacteriol. 78:778–787.
Musajo, L., G. Rodighiero, G. Caporale, F. Dall’acqua, S. Marciani, F. Bordin, F. Bacchichetti, and R. Bevilacqua (1974) Photoreactions between skin-photosensitizing furocoumarins and nucleic acids. In Sunlight and Man, M.A. Pathak. L.C. Harber, M. Seiji, and A. Kukita, eds. University of Tokyo Press, Tokyo, pp. 369–387.
Parrish, J., T. Fitzpatrick, L. Tannenbaum, and M. Pathak (1974) Photochemotherapy of psoriasis with oral methoxypsoralen and long-wave ultraviolet light. New Engl. J. Med. 291:1207–1222.
Pathak M.A., and P.C. Joshi (1984) Production of active oxygen species (and 0) by psoralens and ultraviolet radiation (320–400 nm). Biochim. Biophys. Acta 798:115–126.
Pathak, M.A., and D.M. Kramer (1969) Photosensitization of skin in vivo by furocoumarins (psoralens). Biochim. Biophys. Acta 195:197–206.
Peto, R., R. Doll, J.D. Buckley, and M.B. Sporn (1981) Can dietary carotene materially reduce human cancer rates? Nature 291:201–208.
Poppe, W., and L.I. Grossweiner (1975) Photodynamic sensitization by 8-methoxypsoralen via the singlet oxygen mechanism. Photochem. Photobiol. 22:217–219.
Potapenko, A.Ya., M.V. Moshnin, A.A. Krasnovsky Jr., and V.L. Sukhorukov (1982) Dark oxidation of unsaturated lipids by the photoxidized 8-methoxypsoralen. Z Naturforsch. 37c:70–74.
Potapenko, A.Ya., G.A. Abiev, and F. Pliquett (1980) Inhibition of erythema of the skin photosensitized with 8-methoxypsoralen by α-tocopherol. Bull. Exp. Biol. Med., USSR 89:611–615.
Santamaria, L., L. Bianchi, R. Pizzala, A. Bianchi, and P. Bermond (1984) Antimutagenic action of two carotenoids on mutagenicity induced by 8-methoxypsoralen and long UV irradiation in Salmonella typhimurium TA 102. In Proceedings of the 9th International Congress on Photo-biology and 12th Annual Meeting of the American Society for Photobiology, Philadelphia, Pennsylvania, Abstract No. MPM-C4, p. 22S.
Scheel, L.D., V.B. Perone, R.L. Larkin, and R.E. Kupel (1963) The isolation and characterization of two phototoxic furanocoumarins (psoralens) from diseased celery. Biochemistry 2:1127–1131.
Scotto, J., T.R. Fears, and J.F. Fraumeni Jr. (1981) Incidence of Nonmelanoma Skin Cancer in the United States, National Institutes of Health Publication No. 82–2433.
Seifter, E., G. Rettura, and J. Padawer (1982) Moloney murine sarcoma virus tumors in CBA/J mice: Chemopreventive and chemotherapeutic action of supplemental 3-carotene. J. Natl. Cancer Inst. 68:835–840.
Shapiro, S.S., and A. Bendich (1985) Effect of dietary carotenoids on l3nnphocyte responses to mutagens. Fed. Proc. 45:775.
Singh, H., and J.A. Vadasz (1978) Singlet oxygen: A major reactive species in the furocoumarin photosensitized inactivation of E. coli ribosomes. Photochem. Photobiol. 28:539–545.
Som, S., M. Chatterjee, and M.R. Banerjee (1984) ß-Carotene inhibition of 7,12-dimethyIbenz(a)anthracene-induced transformation of murine mammary cells in vitro. Carcinogenesis 5:937–940.
Song, P.S., M.L. Harter, T.A. Moore, and W.C. Herndon (1971) Luminescence spectra and photocycloaddition of the excited coumarins to DNA bases. Photochem. Photobiol. 14:521–530.
Spikes, J.D. (1975) Porphyrins and related compounds as photodynamic sensitizers. Ann. N.Y. Acad. Sci. 244:496–508.
Vedaldi, D., F. Dall’acqua, A. Gennaro, and G. Rodighiero (1983) Photosensitized effects of furocoumarins: The possible role of singlet oxygen. Z Naturforsch. 38c:866–869.
Veronese, F.M., O. Schiavon, R. Bevilacqua, R. Bordin, and G. Rodighiero (1982) Photoinactivation of enzymes by linear and angular furocoumarins. Photochem. Photobiol. 36:25–30.
Veronese, F.M., O. Schiavon, R. Bevilacqua, and G. Rodighiero (1979) Drug-protein interaction: 8-Methoxypsoralen as photosensitizer of enzjones and amino acids. Z. Naturforsch. 34c:392–396.
Warner, W., A. Giles, and A Kornhauser (1985) Accumulation of dietary 3-carotene in the rat. Nutr. Rep. Int. 32:295–301.
Willett, W.C., and B. MacMahon (1984) Diet and cancer—An overview. New Engl. J. Med. 310:633–638.
Willett, W., B. Polk, B. Underwood, M. Stampfer, S. Pressel, B. Rosner, J. Taylor, K. Schneider, and C. Hames (1984) Relation of serum vitamins A and E and carotenoids to the risk of cancer. New Engl. J. Med. 310:430–434.
Zaynoun, S.T., B.E. Johnson, and W. Frain-Bell (1977) A study of oil of bergamot and its importance as a phototoxic agent. Brit. J. Dermatol. 96:475–482.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 Plenum Press, New York
About this chapter
Cite this chapter
Kornhauser, A., Wamer, W., Giles, A. (1986). Protective Effects of Beta-Carotene Against Psoralen Phototoxicity: Relevance to Protection Against Carcinogenesis. In: Shankel, D.M., Hartman, P.E., Kada, T., Hollaender, A., Wilson, C.M., Kuny, G. (eds) Antimutagenesis and Anticarcinogenesis Mechanisms. Basic Life Sciences, vol 39. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5182-5_41
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5182-5_41
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5184-9
Online ISBN: 978-1-4684-5182-5
eBook Packages: Springer Book Archive