Genetic Aspects of Cancer Epidemiology

  • F. H. Sobels
Part of the Basic Life Sciences book series (BLSC, volume 39)


In this chapter, I will first briefly review to what extent various genetic factors predispose to cancer; second, I will discuss the possible significance in terms of cancer proneness of heterozygotes for ataxia telangiectasia; and third, I want to emphasize the importance of follow-up studies of individuals with an increased level of chromosome aberrations after exposure to mutagens.


Chronic Myeloid Leukemia Chromosome Aberration Ataxia Telangiectasia Ataxia Telangiectasia Cancer Epidemiology 
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  1. 1.
    Ayesh, R., J. R. Idle, J. C. Ritchie, M. J. Crothers, and M. R. Ketzel (1984) Metabolic oxidation phenotypes as markers for susceptibility to lung cancer. Nature 312:169–170.CrossRefGoogle Scholar
  2. 2.
    Bohr, V., and L. Kϕber (1985) DNA repair in lymphocytes from patients with secondary leukemia as measured by strand joining and unscheduled DNA synthesis. Mutat. Res. 146:219–225.Google Scholar
  3. 3.
    Bridges, B. A., G. Lenoir, and L. Tomatis (1985) Workshop on ataxia telangiectasia heterozygotes and cancer. Cancer Res. Vol. 45 (in press).Google Scholar
  4. 4.
    Cavenee, W. K., T. P. Dryja, R. A. Phillips, W. F. Benedict, R. Godbout, L. Gallie, A. L. Murphree, L. C. Strong, and R. L. White (1983) Expression of recessive alleles by chromosomal mechanisms in retinoblastoma. Nature 305:779–781.CrossRefGoogle Scholar
  5. 5.
    Evans, H. J. (1984) Genetic damage and cancer. In Genes and Cancer, J. M. Bishop, J. D. Rowley, and M. Greaves, eds. Alan R. Liss, Inc., New York, pp. 3–18.Google Scholar
  6. 6.
    Gebhard, E. (1984) Chromosomal aberrations In lymphocytes of patients under chemotherapy. In Mutations in Man, G. Obe, ed. Springer-Verlag, Berlin, pp. 198–222.CrossRefGoogle Scholar
  7. 7.
    McKusick, V. A. (1975) Mendelian Inheritance in Man: Catalogs of Autosomal Dominant, Autosomal Recessive, and X-Linked Phenotypes, 4th edition, The Johns Hopkins University Press, Baltimore, London, 837 pp.Google Scholar
  8. 8.
    Mulvihill, J. J. (1984) Clinical ecogenetics and human cancer. In Genes and Cancer, J. M. Bishop, J. D. Rowley, and M. Greaves, eds. Alan R. Liss, Inc., New York, pp. 19–36.Google Scholar
  9. 9.
    Nomura, T. (1984) Quantitative studies on mutagenesis, teratogenesis I and carcinogenesis in mice. In Problems of Threshold in Chemical Mutagenesis, Y. Tazima, S. Kondo, and Y. Kuroda, eds. The Environmental Mutagen Society of Japan, Mishima, Shizuoka, pp. 27–34.Google Scholar
  10. 10.
    Obe, G., D. Göbel, H. Engeln, J. Herka, and A. T. Natarajan (1980) Chromosomal aberrations in peripheral lymphocytes of alcoholics. Mutat. Res. 73:377–386.CrossRefGoogle Scholar
  11. 11.
    Obe, G., W. D. Heller, and H. J. Vogt (1984) Mutagenic activity of cigarette smoke. In Mutations in Man, G. Obe, ed. Springer-Verlag, Berlin, pp. 223–246.CrossRefGoogle Scholar
  12. 12.
    Swift, M. (1982) Disease predisposition of ataxia-telangiectasia heterozygotes. In Ataxia-Telangiectasia a Cellular and Molecular Link between Cancer, Neuropathology and Immune Deficiency, B. A. Bridges and D. G. Harnden, eds. John Wiley and Sons, Inc., Chichester, England, pp. 355–361.Google Scholar
  13. 13.
    Vesell, E. S. (1980) Genetic and environmental factors affecting the metabolism of carcinogens in short term assays for detection of environmental carcinogens. In Molecular and Cellular Aspects of Carcinogen Screening Tests, R. Montesano, H. Bartsch, and L. Tomatis, eds. IARC Scientific Publication No. 27, International Agency for Research on Cancer, Lyon, pp. 23–40.Google Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • F. H. Sobels
    • 1
  1. 1.Department of Radiation Genetics and Chemical Mutagenesis Sylvius LaboratoriesUniversity of LeidenLeidenThe Netherlands

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