Role of Intercellular Communication in Modifying the Consequences of Mutations in Somatic Cells

  • J. E. Trosko
  • C. C. Chang
Part of the Basic Life Sciences book series (BLSC, volume 39)


While there is little question that mutations could play a role in several somatic disease states, it is hard to understand how a mutation in a single cell per se could affect the organism. In the context of these proceedings, prevention of the production of mutations seems to be one approach to the problem of eliminating mutation-dependent diseases. Another approach, which is the aim of this analysis, might be the prevention of the physiological impact of the mutated cell.


Clonal Expansion Tumor Promoter Intercellular Communication Xeroderma Pigmentosum Junctional Communication 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • J. E. Trosko
    • 1
  • C. C. Chang
    • 1
  1. 1.Department of Pediatrics and Human Development Center for Environmental ToxicologyMichigan State UniversityEast LansingUSA

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