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A Mutagen is a Mutagen, Not Necessarily a Carcinogen

  • Earle R. Nestmann
Part of the Basic Life Sciences book series (BLSC, volume 39)

Abstract

A largely unspoken but underlying assumption that has been made by authors throughout these proceedings is that processes involved in antimutagenesis are related to anticarcinogenesis, a corollary of the somatic mutation theory of carcinogenesis. It is generally known that most carcinogens are mutagens, but certainly not all chemicals that are mutagenic in short-term in vitro mutagenicity tests are carcinogens. Reasons that contribute to this lack of concordance are discussed later.

Keywords

Underlying Assumption Mutagenicity Test Toxicology Evaluation Section Department Mutation Theory 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Ames, B. N., W. E. Durston, E. Yamasaki, and F. D. Lee (1973) Carcinogens are mutagens: A simple test system combining liver homogenates for activation and bacteria for detection. Proc. Natl. Acad. Sci., USA 70:2281–2285.CrossRefGoogle Scholar
  2. 2.
    Ashby, J., and I. F. H. Purchase (1985) Significance of the genotoxic activities observed in vitro for 35 of 70 NTP noncarcinogens. Environ. Mutag. 7:747–758.CrossRefGoogle Scholar
  3. 3.
    Cooper, J. A. II, R. Saracci, and P. Cole (1979) Describing the validity of carcinogen screening tests. Brit. J. Cancer 39:87–89.CrossRefGoogle Scholar
  4. 4.
    McCann, J., E. Choi, E. Yamasaki, and B. N. Ames (1975) Detection of carcinogens as mutagens in the Salmonella/microsome test. Part 1. Assay of 300 chemicals. Proc. Natl. Acad. Sci., USA 72:5135–5139.CrossRefGoogle Scholar
  5. 5.
    Purchase, I. F. H. (1982) ICPEMC Working Paper 2/6, an appraisal of predictive tests for carcinogenicity. Mutat. Res. 99:53–71.Google Scholar
  6. 6.
    Shelby, M. D., and S. Stasiewicz (1984) Chemicals showing no evidence of carcinogenicity in long-term, two-species rodent studies: The need for short-term test data. Environ. Mutag. 6:871–878.CrossRefGoogle Scholar
  7. 7.
    Trosko, J. E. (1984) A new paradigm is needed in toxicology evaluation. Environ. Mutag. 6:767–769.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Earle R. Nestmann
    • 1
  1. 1.Department of National Health and WelfareMutagenesis SectionOttawaCanada

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