Mechanisms of Carcinogenicity and Anticarcinogenicity: Role of Dietary Components
The role of nutrition in the etiology of human disease, including cancer, has been recognized for a very long time. This knowledge and, perhaps, personal preference are reflected by the choice and balance of edibles included in the daily diet. Even at present, in certain societies where strong emphasis on traditional values has preserved the dietary patterns of ancient times, the daily diet of most people includes a wide variety of legumes, high in protease inhibitors, and selected vegetables, high in ß-carotene. With our current state of knowledge, we can appreciate the role of tobacco in causing lung cancer and the role of betel quid in the etiology of oral cancer. It may be of interest to note that in certain so cieties, the use of tobacco and betel quid was strictly prohibited as early as the sixteenth-century because of the suspicion that these agents may be involved in the etiology of cardiovascular diseases and cancer.
KeywordsUric Acid Oral Cancer Aromatic Amine Dietary Component Daily Diet
- 1.Correa, P., E. Fontham, L. W. Pickle, V. Chen, Y. Lin, and W. Haenszel (1985) Dietary determinants of gastric cancer in south Louisiana inhabitants. J. Natl. Cancer Inst. 75: 645–654.Google Scholar
- 2.Miller, J. A., and E. C. Miller (1969) The metabolic activation of carcinogenic aromatic amines and amides. Prog. Exp. Tumor Res. 11: 273–301.Google Scholar