Genetic and Chemical Factors Affecting Chemical Mutagenesis in Cultured Mammalian Cells

  • Y. Kuroda
Part of the Basic Life Sciences book series (BLSC, volume 39)


Cultured mammalian cells are useful test systems for detecting chemical mutagens in our environment. These test systems can operate at relatively moderate initial costs in the short time of about 2 weeks, resulting in savings in costs and time, compared with animal test systems. In addition, the effects of mutagens can be estimated quantitatively in cultured mammalian cell systems. Thus, the dose-rate effect of chemicals can be demonstrated along with the possible existence of repair mechanisms in mammalian cells (22, 37).


Syrian Hamster Ames Test 8AGr Mutation Chinese Hamster Cell Chemical Mutagenesis 


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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Y. Kuroda
    • 1
  1. 1.Laboratory of PhenogeneticsNational Institute of GeneticsMishima, Shizuoka 411Japan

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