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Genetic and Chemical Factors Affecting Chemical Mutagenesis in Cultured Mammalian Cells

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Book cover Antimutagenesis and Anticarcinogenesis Mechanisms

Part of the book series: Basic Life Sciences ((BLSC,volume 39))

Abstract

Cultured mammalian cells are useful test systems for detecting chemical mutagens in our environment. These test systems can operate at relatively moderate initial costs in the short time of about 2 weeks, resulting in savings in costs and time, compared with animal test systems. In addition, the effects of mutagens can be estimated quantitatively in cultured mammalian cell systems. Thus, the dose-rate effect of chemicals can be demonstrated along with the possible existence of repair mechanisms in mammalian cells (22, 37).

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Authors and Affiliations

  1. Laboratory of Phenogenetics, National Institute of Genetics, Mishima, Shizuoka 411, Japan

    Y. Kuroda

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  1. Y. Kuroda
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Editors and Affiliations

  1. University of Kansas, Lawrence, Kansas, USA

    Delbert M. Shankel

  2. Johns Hopkins University, Baltimore, Maryland, USA

    Philip E. Hartman

  3. National Institute of Genetics, Mishima, Japan

    Tsuneo Kada

  4. Council for Research Planning in Biological Sciences, Inc., Washington, D.C., USA

    Alexander Hollaender , Claire M. Wilson  & Gregory Kuny ,  & 

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© 1986 Plenum Press, New York

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Kuroda, Y. (1986). Genetic and Chemical Factors Affecting Chemical Mutagenesis in Cultured Mammalian Cells. In: Shankel, D.M., Hartman, P.E., Kada, T., Hollaender, A., Wilson, C.M., Kuny, G. (eds) Antimutagenesis and Anticarcinogenesis Mechanisms. Basic Life Sciences, vol 39. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5182-5_31

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  • DOI: https://doi.org/10.1007/978-1-4684-5182-5_31

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5184-9

  • Online ISBN: 978-1-4684-5182-5

  • eBook Packages: Springer Book Archive

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