The Relation of Activation and Inactivation to Antimutagenic Processes

  • R. C. von Borstel
Part of the Basic Life Sciences book series (BLSC, volume 39)


Antimutagenesis is the lowering of spontaneous mutation rates and induced mutation frequencies by exogenous conditions. The field has been divided into two parts by Kada (5): desmutagenesis and antimutagenesis per se. Desmutagenesis refers to inactivation of mutagens and carcinogens by whatever means, whether by antioxidants, by cytochrome P-450-associated activity, or by the active destruction or absorption of the toxic substances before they can enter the target cell. Antimutagenesis then becomes either the enhancement of the nonmutagenic repair of DNA, the inactivation of mutagenic repair, the inactivation of the SOS repair processes, or some interference with the expression of mutations.


Radical Trapping Radical Trap Spontaneous Mutation Rate Exogenous Condition Active Destruction 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • R. C. von Borstel
    • 1
  1. 1.Department of GeneticsUniversity of AlbertaEdmonton, AlbertaCanada

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