Multiple Inducible Cytochromes P-450 in Yeast
A form of cytochrome P-450 is produced in Saccharomyces cerevisiae during the logarithmic growth phase (14). This form is inhibited by metyrapone, tetrahydrofurane, and carbon oxide which are inhibitors of ethanolinducible cytochromes P-450 of mammals. Addition of Na-phenobarbital to the 0.5% glucose liquid medium induced a form of cytochrome P-450 inhibited only by metyrapone. Thus, yeast possess multiple forms of cytochrome P-450 that are individually inducible.
KeywordsCarbon Oxide Logarithmic Growth Phase Microsomal Cytochrome Post Mitochondrial Supernatant Mitotic Gene Conversion
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