Inducible Cellular Responses to DNA Damage in Mammalian Cells

  • Michael E. Lambert
  • James I. Garrels
  • John McDonald
  • I. Bernard Weinstein
Part of the Basic Life Sciences book series (BLSC, volume 39)


The mechanisms by which chemical carcinogens induce cellular transformation are unknown. Polycyclic aromatic hydrocarbons, such as benzo(α)pyrene (BP), have been extensively studied, and their chemical properties, metabolic activation, and DNA-binding properties have been elucidated in great detail (34). There is also evidence that covalent binding of metabolites of these and of other carcinogens to cellular DNA is a critical event in their action as carcinogens (77). The subsequent series of biochemical and genetic events, however, that lead to the conversion of a normal cell to a cancer cell are not known.


Heat Shock Cellular Gene Chemical Carcinogen Chloramphenicol Acetyl Transferase Chemical Carcinogenesis 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Michael E. Lambert
    • 1
  • James I. Garrels
    • 1
  • John McDonald
    • 2
  • I. Bernard Weinstein
    • 3
  1. 1.Cold Spring Harbor LaboratoryCold Spring HarborNew YorkUSA
  2. 2.Department of GeneticsUniversity of GeorgiaAthensUSA
  3. 3.Comprehensive Cancer CenterColumbia UniversityNew YorkUSA

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