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Inducible Cellular Responses to DNA Damage in Mammalian Cells

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Antimutagenesis and Anticarcinogenesis Mechanisms

Part of the book series: Basic Life Sciences ((BLSC,volume 39))

Abstract

The mechanisms by which chemical carcinogens induce cellular transformation are unknown. Polycyclic aromatic hydrocarbons, such as benzo(α)pyrene (BP), have been extensively studied, and their chemical properties, metabolic activation, and DNA-binding properties have been elucidated in great detail (34). There is also evidence that covalent binding of metabolites of these and of other carcinogens to cellular DNA is a critical event in their action as carcinogens (77). The subsequent series of biochemical and genetic events, however, that lead to the conversion of a normal cell to a cancer cell are not known.

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Authors and Affiliations

  1. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, 11724, USA

    Michael E. Lambert & James I. Garrels

  2. Department of Genetics, University of Georgia, Athens, Georgia, 30602, USA

    John McDonald

  3. Comprehensive Cancer Center, Columbia University, New York, New York, 10032, USA

    I. Bernard Weinstein

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  1. Michael E. Lambert
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  2. James I. Garrels
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Editor information

Editors and Affiliations

  1. University of Kansas, Lawrence, Kansas, USA

    Delbert M. Shankel

  2. Johns Hopkins University, Baltimore, Maryland, USA

    Philip E. Hartman

  3. National Institute of Genetics, Mishima, Japan

    Tsuneo Kada

  4. Council for Research Planning in Biological Sciences, Inc., Washington, D.C., USA

    Alexander Hollaender , Claire M. Wilson  & Gregory Kuny ,  & 

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© 1986 Plenum Press, New York

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Lambert, M.E., Garrels, J.I., McDonald, J., Weinstein, I.B. (1986). Inducible Cellular Responses to DNA Damage in Mammalian Cells. In: Shankel, D.M., Hartman, P.E., Kada, T., Hollaender, A., Wilson, C.M., Kuny, G. (eds) Antimutagenesis and Anticarcinogenesis Mechanisms. Basic Life Sciences, vol 39. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5182-5_25

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  • DOI: https://doi.org/10.1007/978-1-4684-5182-5_25

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