Role of Enzymes in Antimutagenesis of Human Saliva and Serum

  • H. Nishioka
  • T. Nunoshiba
Part of the Basic Life Sciences book series (BLSC, volume 39)


In order to evaluate the risk of dietary environmental mutagens and/or carcinogens to man and to search for protection from them, it is important to study possible modifications in every part of the digestive tract.


Healthy Donor Nicotinamide Adenine Dinucleotide Phosphate Human Saliva Mutagenicity Assay Methyl Methanesulfonate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Ames, B.N., J. McCann, and E. Yamasaki (1975) Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. Mutat. Res. 31:347.Google Scholar
  2. 2.
    Nagao, M., M. Honda, Y. Seino, T. Yahagi, and T. Sugimura (1977) Mutagenicities of smoke condensates and the charred surface of fish and meat. Cancer Lett. 2:221.CrossRefGoogle Scholar
  3. 3.
    Nagao, M., M. Honda, Y. Seino, T. Yahagi, T. Kawachi, and T. Sugimura (1977) Mutagenicities of protein pyrolysates. Cancer Lett. 2:334.Google Scholar
  4. 4.
    Nebert, D.W., S.W. Bigelow, A.B. Okey, T. Yahagi, Y. Mori, M. Nagao, and T. Sugimura (1979) Pyrolysis products from amino acids and protein: Highest mutagenicity requires cytochrome P -450. Proc. Natl. Acad. Sci., USA 76:5929.CrossRefGoogle Scholar
  5. 5.
    Nishioka, H. (1983) Antimutagenic activity of human saliva and serum. In Carcinogens and Mutagens in the Environment. Vol. 2. Naturally Occurring Compounds, CRC Press, Inc., Boca Raton, Florida, pp. 77–83.Google Scholar
  6. 6.
    Nishioka, H., and K. Nishi (1981) Effect of human saliva and its components on mutagenicity of carcinogens. Sci. Eng. Rev. Doshisha Univ. 22:62.Google Scholar
  7. 7.
    Nishioka, H., K. Nishi, and K. Kyokane (1981) Human saliva inactivates mutagenicity of carcinogens. Mutat. Res. 85:323.Google Scholar
  8. 8.
    Odashima, S., and Y. Hashimoto (1970) Carcinogenicity and target organs of methoxyl derivatives of 4 aminoazo-1 benzene in rats. Gann 61:153.Google Scholar
  9. 9.
    Sato, S., Y. Seino, T. Ohka, T. Yahagi, M. Nagao, T. Matsushima, and T. Sugimura (1977) Mutagenicity of smoke condensates from cigarettes, cigars and pipe tobacco. Cancer Lett. 3:1.CrossRefGoogle Scholar
  10. 10.
    Shannon, I.L., R.P. Süddiek, and F.J. Dowd, Jr. (1974) Saliva; Composition and Secretion (Monograph in Oral Science), S. Karger, Basel, p. 2.Google Scholar
  11. 11.
    Toyoda, M., Y. Ito, M. Iwaida, and M. Fujii (1982) Rapid procedure for the determination of minute quantities of residual hydrogen peroxide in food by using a sensitive oxygen electrode. J. Agric. Food Chem. 30: 346–349CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • H. Nishioka
    • 1
  • T. Nunoshiba
    • 1
  1. 1.Department of BiochemistryDoshisha UniversityKyoto 602Japan

Personalised recommendations