Abstract
Oxygen is indispensable for aerobic organisms including, of course, human beings, but it is believed that oxygen also may be responsible for undesired phenomena. In particular, oxygen species such as hydrogen peroxide, superoxide radical anion, and singlet oxygen are proposed as agents attacking polyunsaturated fatty acids in cell membranes, giving rise to lipid peroxidation. Several reports have suggested that lipid peroxidation may result in destabilization and disintegration of cell membranes, leading to liver injury and other diseases, and finally, to aging and susceptibility to cancer (4).
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Ames, B.N., R. Cathcart, E. Schwiers, and P. Hochstein (1981) Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: A hypothesis, Proc. Natl. Acad. Sci., USA 78(11):6858–6862.
Levin, D.E., M. Hollstein, M.F. Christman, E.A. Schwiers, and B.N. Ames (1982) A new Salmonella tester strain (TA 102) with A.T base pairs at the site of mutation detects oxidative mutagens. Proc. Natl. Acad. Sci., USA 79:7445–7449.
Fukuda, Y. T, Osawa, M. Namiki, and T. Ozaki (1985) Studies on anti-oxidative substances in sesame seed. Agric. Biol. Chem. 49(2):301–306.
McBrien, D.C.H., and T.F. Slater (1982) Free Radicals, Peroxidation and Cancer, Academic Press, New York.
Mimnaugh, E.G., T.E. Gram, and M.A. Trush (1983) Stimulation of mouse heart and liver microsomal lipid peroxidation by anthracycline anti-cancer drugs: Characterization and effects of reactive oxygen scaven-gers. J. Pharm. Exper. Therapeu. 226(3):806–816.
Mukai, F.H., and HHH. Goldstein (1976) Mutagenicity of malonaldehyde, a de-composition product of peroxidized polyunsaturated fatty acids. Science 191:868–869.
Osawa, T., and M. Namiki (1981) A novel type of antioxidant isolated from leaf wax of eucalyptus leaves. Agric. Biol. Chem. 45(3):735–739.
Osawa, T., and M. Namiki (1983) Natural antioxidants isolated from plant leaf waxes. In Research in Food Science and Nutrition, Vol. 3, J.V. McLoughlin and B.M. McKenna, eds. Boole Press, Dublin, pp. 49–50.
Osawa, T., and M. Namiki (1985) Natural antioxidants isolated from eu-calyptus leaf waxes. J. Agric. Food Chem. 33(5):77–80.
Osawa, T., M. Nagata, M. Namiki, and Y. Fukuda (1985) Sesamolinol, a novel antioxidant isolated from sesame seeds. Agric. Biol. Chem. 49(11):3351–3352.
Pederson, T.C., J.A. Buege, and S.D. Aust (1973) Microsomal electron transport. J. Biol. Chem. 248(20):7134–7141.
Pryor, W.A., ed. (1980) Free Radicals in Biology, Vol. IV, Academic Press, New York.
Shamberger, R.J., and G. Rudolph (1966) Protection against co-carcino- genesis by antioxidants, Experientia 22:116.
Shamberger, R.J. (1970) Relationship of selenium to cancer. I. Inhib-itory effect of selenium on carcinogenesis. J. Natl. Cancer Inst. 44:931–936.
Simic, G.M., and M. Karel, eds. (1980) Autoxidation in Food and Biological Systems, Plenum Press, New York and London.
Wattenberg, L.W. (1972) Inhibition of carcinogenic and toxic effects of polycyclic hydrocarbons by phenolic antioxidants and ethoxyquin. J. Natl. Cancer Inst. 48:1425–1430
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© 1986 Plenum Press, New York
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Namiki, M., Osawa, T. (1986). Antioxidants/Antimutagens in Foods. In: Shankel, D.M., Hartman, P.E., Kada, T., Hollaender, A., Wilson, C.M., Kuny, G. (eds) Antimutagenesis and Anticarcinogenesis Mechanisms. Basic Life Sciences, vol 39. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5182-5_11
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DOI: https://doi.org/10.1007/978-1-4684-5182-5_11
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