Advertisement

Morphometric Methods for the Evaluation of the Cochlear Microvasculature

  • Lynn Carlisle
Part of the NATO ASI Series book series (NSSA, volume 111)

Abstract

Although the vasculature of the cochlea has been implicated in a number of etiologies of deafness, experimental verification for such an involvement has proved to be difficult; part of the reason for this difficulty is that, until recently, studies of the cochlear vasculature have been descriptive rather than quantitative. Descriptive studies have contributed significantly to our understanding of gross vascular pathology in the cochlea; however, it is difficult to document subtle morphological changes without resorting to quantitative methods. Since subtle changes in the blood supply to the cochlea may be involved in such clinical conditions as tinnitus, Meniere’s disease and temporary threshold shift following acoustic trauma, there has been considerable interest in developing quantitative methods for the analysis of the cochlear vasculature. Several such techniques are described in this chapter, following a brief review of the vascular anatomy of the cochlea.

Keywords

Impulse Noise Vessel Lumen Vascular Density Stria Vascularis Spiral Ligament 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    C. A. Smith, Capillary areas of the cochlea in the guinea pig, Laryngoscope 61:1073 (1951).CrossRefGoogle Scholar
  2. 2.
    J. E. Hawkins, Jr., Vascular patterns of the membranous labyrinth, in: “Third Symposium on the Vestibular Organs in SPACE Exploration,” A. Graybiel, ed., NASA, Washington (1968).Google Scholar
  3. 3.
    A. Axelsson, The vascular anatomy of the cochlea in the guinea pig and in man, Acta Otolaryngol. Suppl. 243 (1968).Google Scholar
  4. 4.
    R. S. Kimura and C. Y. Ota, Ultrastructure of the cochlear blood vessels, Acta Otolaryngol. 77:231 (1974).CrossRefGoogle Scholar
  5. 5.
    M. Lawrence, The function of the spiral capillaries, Laryngoscope 81:1314 (1971).CrossRefGoogle Scholar
  6. 6.
    S. K. Bosher and R. L. Warren, Observations on the electrochemistry of the cochlear endolymph in the rat: A quantitative study of its electrical potential and ionic composition as determined by means of flame spectrophotometry, Proc. R. Soc. Lond. B 171:227 (1968).CrossRefGoogle Scholar
  7. 7.
    I. Tasaki and C. S. Spyropoulos, Stria vascularis as source of endocochlear potential, J. Neurophysiol. 22:149 (1959).Google Scholar
  8. 8.
    C. A. Smith, Structure of the stria vascularis and the spiral prominence, Ann. Otol. Rhinol. Laryngol. 66:521 (1957).Google Scholar
  9. 9.
    P. A. Santi, B. Lakhani, and C. Bingham, The volume density of cells and capillaries of the normal stria vascularis, Hearing Res. 11:7 (1983).CrossRefGoogle Scholar
  10. 10.
    D. A. Hilding and R. D. Ginzberg, Pigmentation of the stria vascularis, Acta Otolaryngol. 84:24 (1977).CrossRefGoogle Scholar
  11. 11.
    P. A. Santi and B. N. Lakhani, The effect of bumetanide on the stria vascularis: A stereological analysis of cell volume density, Hearing Res. 12:151 (1983).CrossRefGoogle Scholar
  12. 12.
    D. I. Smith, M. Lawrence and J. E. Hawkins, Jr., Effects of noise and quinine on the vessels of the stria vascularis: An image analysis study, Am. J. Otolaryngol. 6:280 (1985).CrossRefGoogle Scholar
  13. 13.
    A. Axelsson, J. Miller, and J. Holmquist, Studies of cochlear vasculature and sensory structures: A modified method, Ann Otol. 83:537 (1974).Google Scholar
  14. 14.
    A. Axelsson, J. Miller, and B. Larsson, A modified “soft surface specimen technique” for examination of the inner ear, Acta Otolarynol. 80:362 (1975).CrossRefGoogle Scholar
  15. 15.
    D. Vertes and A. Axelsson, Methodological aspects of some inner ear vascular techniques, Acta Otolarynol. 88:328 (1979).CrossRefGoogle Scholar
  16. 16.
    L. C. Shaddock, R. P. Hamernik and A. Axelsson, Effect of high intensity impulse noise on the vascular system of the chinchilla cochlear, Ann. Otol. Rhinol. Laryngol. 94:87 (1985).Google Scholar
  17. 17.
    L. C. Shaddock, R. P. Hamernik, and A. Axelsson, Cochlear vascular and sensory cell changes induced by elevated temperature and noise, Am. J. Otolarynol. 5:99 (1984).CrossRefGoogle Scholar
  18. 18.
    A. Axelsson and D. Vertes, Histological findings in cochlear vessels after noise, in: “New Perspectives on Noise-Induced Hearing Loss” R. P. Hamernik Henderson and R. Salvi, eds. Raven Press, New York (1982).Google Scholar
  19. 19.
    L. C. Shaddock, R. P. Hamernik, and C. G. Wright, A morphometric technique for the analysis of cochlear vessels, Hearing Res. (1985), in press.Google Scholar
  20. 20.
    L. C. Shaddock, C. G. Wright and R. P. Hamernik, A morphometric study of microvascular pathology following experimental rupture of Reissner’s membrane, Hearing Res. (1985), in press.Google Scholar
  21. 21.
    B. M. Altura, Humoral, hormonal and myogenic mechanisms in micro-circulatory regulation, in: “Microcirculation III,” G. Kaley and B. M. Altura, eds., University Park Press (1980).Google Scholar
  22. 22.
    D. Longnecker and P. R. Harris, Anesthesia, in: “Microcirculation III,” G. Kaley and B. M. Altura, eds., University Park Press, (1980).Google Scholar
  23. 23.
    P. A. Santi and A. J. Duvall, Morphological alteration of the stria vascularis after administration of the diuretic bumetanide, Acta Otolaryngol. 88:1 (1979).CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Lynn Carlisle
    • 1
  1. 1.Kresge Hearing Research InstituteUniversity of MichiganAnn ArborUSA

Personalised recommendations