Some Issues Associated with Interactions Between Ototoxic Drugs and Exposure to Intense Sounds

  • Dennis McFadden
Part of the NATO ASI Series book series (NSSA, volume 111)


Certain commonly-used drugs can produce hearing loss having many of the same physiological and psychophysical features as hearing loss induced by exposure to intense sound. Until quite recently, little research had been done on the question of possible interactions between drug-induced hearing loss (DIHL) and exposure-induced hearing loss (EIHL), and the vast majority of what had been done concentrated on drugs which themselves cause permanent threshold shift (PTS) [1–3]. In recent times, however, some studies have been done with drugs which are themselves responsible only for temporary hearing loss, and the results of this work have raised the need for specialists working in the area of EIHL to consider again some logical and practical problems they have struggled with in the past. My goal in this chapter is to raise some of these problems for discussion, in the context of a brief review of our recent research on the interactions between EIHL and hearing loss induced by salicylates.


Hearing Loss Hair Cell Noise Exposure Cochlear Microphonic Cochlear Hair Cell 


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  1. 1.
    S. A. Falk, Combined effects of noise and ototoxic drugs, Environ. Health Perspectives, 4:5 (1972).CrossRefGoogle Scholar
  2. 2.
    R. P. Hamernik and D. Henderson, The potentiation of noise by other ototraumatic agents, in: “Effects of Noise on Hearing” eds., D. Henderson, R. P. Hamernik, D. S. Dosanjh, and J. H. Mills, Raven Press, New York pp. 291–307 (1976).Google Scholar
  3. 3.
    L. E. Humes, Noise-induced hearing loss as influenced by other agents and by some physical characteristics of the individual, J. Acoust. Soc. Am., 76:1318 (1984).CrossRefGoogle Scholar
  4. 4.
    D. McFadden and H. S. Plattsmier, Aspirin can potentiate the temporary hearing loss induced by intense sounds, Hearing Research, 9:295 (1983).CrossRefGoogle Scholar
  5. 5.
    D. McFadden, H. S. Plattsmier, and E. G. Pasanen, Temporary hearing loss induced by combinations of intense sounds and nonsteroidal anti-inflammatory drugs, Am. J. Otolaryngol., 5:235 (1984a).CrossRefGoogle Scholar
  6. 6.
    W. D. Ward, Auditory fatigue and masking, in: “Modern Developments in Audiology,” ed., J. Jerger, Academic Press, New York, pp. 240–286 (1963).Google Scholar
  7. 7.
    J. Viall and W. Melnick, Asymptotic threshold shift in people with sensorineural hearing loss, Trans. Amer. Acad. Ophthalmol. Otolaryngol., 84:459 (1977).Google Scholar
  8. 8.
    J. H. Mills, Threshold shifts produced by exposure to noise in chinchillas with noise-induced hearing losses, J. Speech Hear. Res., 16:700 (1973).Google Scholar
  9. 9.
    P. A. McCabe and F. L. Dey, The effect of aspirin upon auditory sensitivity, Ann. Otol. Rhinol. Laryngol., 74:312 (1965).Google Scholar
  10. 10.
    J. D. Miller, Effects of noise on people, J. Acoust. Soc. Am., 56:729 (1974).CrossRefGoogle Scholar
  11. 11.
    W. D. Ward, Noise-induced hearing loss: Research since 1978, Photocopy of talk delivered at 4th International Congress on Noise as a Public Health Hazard, Turin, Italy (1983).Google Scholar
  12. 12.
    J. M. Valeton, Photoreceptor light adaptation models: an evaluation, Vision Research, 23:1549 (1983).CrossRefGoogle Scholar
  13. 13.
    W. D. Ward, Adaptation and fatigue, in: “Sensorineural Hearing Processes and Disorders,” ed., A. B. Graham, Little Brown, Boston, pp. 113–121 (1967).Google Scholar
  14. 14.
    M. C. Liberman and M. J. Mulroy, Acute and chronic effects of acoustic trauma: Cochlear pathology and auditory nerve pathophysiology, in: “New Perspectives on Noise-Induced Hearing Loss” eds., R. P. Hamernik, D. Henderson, and R. Salvi, Raven Press, New York, pp. 105–135 (1982).Google Scholar
  15. 15.
    D. T. Kemp, Stimulated acoustic emissions from within the human auditory system, J. Acoust. Soc. Am., 64:1386 (1978).CrossRefGoogle Scholar
  16. 16.
    D. McFadden and H. S. Plattsmier, Aspirin abolishes spontaneous oto-acoustic emissions, J. Acoust. Soc. Am., 76:443 (1984).CrossRefGoogle Scholar
  17. 17.
    D. McFadden, H. S. Plattsmier, and E. G. Pasanen, Aspirin-induced hearing loss as a model of sensorineural hearing loss, Hearing Research, 16:251 (1984b).CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Dennis McFadden
    • 1
  1. 1.Department of PsychologyUniversity of TexasAustinUSA

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