Some Issues Associated with Interactions Between Ototoxic Drugs and Exposure to Intense Sounds
Certain commonly-used drugs can produce hearing loss having many of the same physiological and psychophysical features as hearing loss induced by exposure to intense sound. Until quite recently, little research had been done on the question of possible interactions between drug-induced hearing loss (DIHL) and exposure-induced hearing loss (EIHL), and the vast majority of what had been done concentrated on drugs which themselves cause permanent threshold shift (PTS) [1–3]. In recent times, however, some studies have been done with drugs which are themselves responsible only for temporary hearing loss, and the results of this work have raised the need for specialists working in the area of EIHL to consider again some logical and practical problems they have struggled with in the past. My goal in this chapter is to raise some of these problems for discussion, in the context of a brief review of our recent research on the interactions between EIHL and hearing loss induced by salicylates.
KeywordsHearing Loss Hair Cell Noise Exposure Cochlear Microphonic Cochlear Hair Cell
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