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Mechanical Changes in Stereocilia Following Overstimulation: Observations and Possible Mechanisms

  • James C. Saunders
  • Barbara Canlon
  • Ake Flock
Part of the NATO ASI Series book series (NSSA, volume 111)

Abstract

Many experimental observations over the past decade have indicated that the role of stereocilia structure and function in cochlear hair-cell transduction is more complicated than previously thought. Among these recent observations are those that elucidated the cytoskeletal organization of the stereocilia and cuticular plate [21,81], and the extracellular structures that bind individual stereocilia together [6,50,51]. In addition, the kinetics of hair-cell physiology have been well described [7,9, 55] and the directional sensitivity of stereocilia movement on individual hair cells is now known [22,28,75]. Descriptions of static and dynamic stereocilia movement in the mammalian cochlea have recently been presented [23,38,75]; these data are critically important to our understanding of hair-cell function and dysfunction.

Keywords

Hair Cell Actin Filament Noise Exposure Threshold Shift Sensory Hair 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • James C. Saunders
    • 1
    • 2
  • Barbara Canlon
    • 1
    • 2
  • Ake Flock
    • 1
    • 2
  1. 1.Department of Otorhinolaryngology and Human CommunicationUniversity of PennsylvaniaPhiladelphiaUSA
  2. 2.Department of Physiology IIKarolinska InstituteStockholmSweden

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