Critical Periods of Susceptibility to Noise-Induced Hearing Loss

  • Marc Lenoir
  • Remy Pujol
  • Gregory R. Bock
Part of the NATO ASI Series book series (NSSA, volume 111)


Deafness in children has deleterious effects on the development of speech, language and listening skills [1]. A large number of factors contribute to hearing losses in the perinatal periods. Congenital infections, such as toxoplasmosis, rubella, cytomegallovirus and others [2] have been recognized as possible etiological factors of auditory dysfunction. Evidence for early conductive and perceptual deficits of genetic origin has been found in experimental models of hereditary hearing impairment [3]. Moreover, it has been proposed that early exposures to physical and chemical agents such as noise and ototoxic drugs, which have noxious influences on the auditory receptors in adults [4,5] may drastically increase the probability of deafness in young subjects [6–8]. This conclusion receives strong support from experimental studies, which demonstrate critical periods of susceptibility to acoustic and ototoxic trauma in young animals [9].


Hearing Loss Critical Period Noise Exposure Congenital Hypothyroidism Audiogenic Seizure 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Marc Lenoir
    • 1
  • Remy Pujol
    • 1
  • Gregory R. Bock
    • 2
  1. 1.Lab. Neurobiologie de I’AuditionINSERM-U. 254Montpellier CedexFrance
  2. 2.The Ciba FoundationLondonUK

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