Z-RNA: A Left-Handed Double Helix
The synthetic polyribonucleotide, poly [r(G-C)], has been shown to undergo a transition from the right handed A-form to a left-handed Z-conformation.1 This is the first major conformational change found in double-stranded RNA.2 Therefore it is important to corroborate this observation, to characterize the conditions that produce Z-RNA, and to determine some of the properties of this novel left-handed structure. This article is a summary of our results in this area.
KeywordsCircular Dichroism Circular Dichroism Spectrum Single Strand Circular Dichroism Measurement Slow Exchange
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