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Molecular Dynamics Simulation of the Anticodon Arm of Phenylalanine Transfer RNA

  • Lennart Nilsson
  • Martin Karplus
Part of the NATO ASI Series book series (NSSA, volume 110)

Abstract

Nucleic acid structures (Saenger, 1984), range from the classical double helices of A- and B-DNA, the detailed 3 D structures of crystalline tRNA (Kim et al., 1974; Ladner et al., 1975) to various DNA oligonucleotides in both left handed and right handed helical forms, for which there now is a wealth of experimental data (Saenger, 1984). This structural diversity has prompted numerous theoretical studies of the equilibrium properties of nucleic acids (see Olson, 1982, and references therein). By contrast only a very limited number of dynamical simulations of DNA (Levitt, 1983; Tidor et al., 1983) and tRNA (Harvey et al., 1984) have been reported.

Keywords

Hydrogen Bond Length tRNA Molecule Anticodon Loop Nucleic Acid Structure Anisotropy Decay 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Lennart Nilsson
    • 1
  • Martin Karplus
    • 2
  1. 1.Department of Medical BiophysicsKarolinska InstitutetStockholmSweden
  2. 2.Department of ChemistryHarvard UniversityCambridgeUSA

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