Gene Transfer pp 117-148 | Cite as

Vectors for Gene Transfer Derived from Animal DNA Viruses: Transient and Stable Expression of Transferred Genes

  • Vijay R. Baichwal
  • Bill Sugden

Abstract

In this chapter, a “vector” is defined as a DNA molecule that facilitates the intracellular expression of genes inserted into it. Vectors that contain inserted genes will be termed “recombinant vectors.” Most eukaryotic vectors to date contain DNA sequences derived from viruses, and those derived from animal DNA viruses are eclectic. They may or may not be infectious; they may or may not replicate autonomously; they may permit the expression of an inserted gene transiently or indefinitely. They have been derived from papova-, parvo-, adeno-, herpes-, and poxviruses. Few have been studied in great detail, and reference to them in the literature is often incidental. We shall try to abstract from recent literature general findings derived from the construction and use of vectors developed from animal DNA viruses. These abstracts will not be complete; however, we shall present examples from each of the cited families of DNA viruses. Many recent experiments have used cis-acting elements [e.g., simian virus 40 (SV40) 72-base-pair (bp) repeat or the herpes simplex type 1 thymidine kinase promoter] derived from viruses that affect transcription of linked genes in otherwise nonviral recombinant DNAs. Whether or not these recombinant DNAs should be termed viral vectors is moot. We shall refer only occasionally to the large body of observations in which they were used. We hope that readers who have not used vectors derived from animal DNA viruses can in reading this review identify likely candidates to fulfill their needs and then turn to the cited primary sources for professional help.

Keywords

Codon Recombination Influenza Sarcoma Interferon 

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Vijay R. Baichwal
    • 1
  • Bill Sugden
    • 1
  1. 1.McArdle Laboratory for Cancer ResearchUniversity of WisconsinMadisonUSA

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