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Antibody-Mediated Cytotoxicity

  • James W. Kazura

Abstract

Contact of an Fc receptor (FcR)-bearing effector cell and a potential biologic target may occur in the presence of antibodies directed against the surface of the target. When this interaction culminates in damage or killing of the biologic target, it is referred to as antibody-dependent cell-mediated cytotoxicity (ADCC). A multitude of studies indicate that ADCC reactions are involved in immune functions which may be beneficial or deleterious to the whole animal. For example, allograft and tumor rejection, viral resistance (Cerottini and Brunner, 1974; Kohl et al., 1977), and host defense against multicellular helminths (Ellner and Mahmoud, 1982) are in large part effected by ADCC reactions. On the other hand, life-threatening disease states such as immune thrombocytopenic purpura and immune hemolytic anemia also involve ADCC reactions (Kurlander et al., 1978).

Keywords

Natural Killing Effector Cell Immune Thrombocytopenic Purpura Schistosoma Mansoni ADCC Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • James W. Kazura
    • 1
  1. 1.Division of Geographic Medicine, Department of MedicineCase Western Reserve University and University HospitalsClevelandUSA

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