Leukocyte Function in Human Allergic Disease

  • Michael R. Simon


Human allergic disease is mediated by antigen-specific IgE which fixes to a high-affinity receptor on the surfaces of mast cells and basophils. Antigen bridging of adjacent IgE molecules results in the release of mediators of Type I hypersensitivity. These include histamine, neutrophil chemotactic factors, eosinophil chemotactic factor of anaphylaxis (ECF-A), and platelet-activating factor (PAF) (Plaut and Lichtenstein, 1978). In turn, these substances affect various other leukocytes.


Atopic Dermatitis Thymidine Incorporation Suppressor Cell Histamine Receptor Neutrophil Chemotaxis 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Michael R. Simon
    • 1
    • 2
  1. 1.Medical and Research ServicesVeterans Administration Medical CenterAllen ParkUSA
  2. 2.Department of MedicineWayne State University School of MedicineDetroitUSA

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