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Interaction of Phagocytic Cells with Immune Complexes of Anaphylactic Antibodies

  • Jean-Paul Dessaint
  • André Capron

Abstract

The chief mechanism of clearance of antigen-antibody complexes by cells of the reticuloendothelial system is for complexes containing intact IgG molecules to bind the various Fc receptors on the surface of mononuclear and polynuclear phagocytes. Similarly, phagocytosis of IgG antibody-opsonized particles by such cells requires binding to Fc receptors, and macrophages bind immune IgG com-plexes with up to four orders of magnitude greater affinity than for monomeric IgG (reviewed by McKeever and Spicer, 1980). In response to their interaction with opsonized particles or immune complexes, macrophages either release lysosomal granule enzymes to the surrounding medium (Cardella et al., 1974) or undergo selective phagocytic paralysis (Rabinovitch et al., 1975).

Keywords

Mast Cell Immune Complex Mononuclear Phagocyte Schistosoma Mansoni IgG2a Antibody 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Jean-Paul Dessaint
    • 1
    • 2
  • André Capron
    • 1
    • 2
  1. 1.Centre d’Immunologie et de Biologie ParasitaireINSERM U-167Lille CedexFrance
  2. 2.Institut PasteurCNRS 624Lille CedexFrance

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