Interaction of Phagocytic Cells with Immune Complexes of Anaphylactic Antibodies

  • Jean-Paul Dessaint
  • André Capron


The chief mechanism of clearance of antigen-antibody complexes by cells of the reticuloendothelial system is for complexes containing intact IgG molecules to bind the various Fc receptors on the surface of mononuclear and polynuclear phagocytes. Similarly, phagocytosis of IgG antibody-opsonized particles by such cells requires binding to Fc receptors, and macrophages bind immune IgG com-plexes with up to four orders of magnitude greater affinity than for monomeric IgG (reviewed by McKeever and Spicer, 1980). In response to their interaction with opsonized particles or immune complexes, macrophages either release lysosomal granule enzymes to the surrounding medium (Cardella et al., 1974) or undergo selective phagocytic paralysis (Rabinovitch et al., 1975).


Mast Cell Immune Complex Mononuclear Phagocyte Schistosoma Mansoni IgG2a Antibody 
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  1. Aime, N., Haque, A., Bonnel, B., Torpier, G., and Capron, A., 1984, Neutrophil-mediated killing of Dipetalonema viteae microfilariae: Simultaneous presence of IgE, IgG antibodies and complement is required, Immunology 51: 585.PubMedGoogle Scholar
  2. Anderson, C. L., and Spiegelberg, H. L., 1981, Macrophage receptors for IgE: Binding of IgE to specific IgE Fc receptors on a human macrophage cell line, U937, J. Immunol. 126: 2470.PubMedGoogle Scholar
  3. Anwar, A. R. E., Smithers, S. R., and Kay, A. B., 1979, Killing of schistosomula of Schistosoma mansoni coated with antibody and/or complement by human leukocytes: In vitro requirement for complement in preferential killing by eosinophils, J. Immunol. 122: 628.PubMedGoogle Scholar
  4. Auriault, C., Joseph, M., Dessaint, J.-P., and Capron, A., 1980, Inactivation of rat macrophages by peptides resulting from cleavage of IgG by schistosome larvae proteases, Immunol. Lett. 2: 135.CrossRefGoogle Scholar
  5. Auriault, C., Capron, M., Cesari, I., and Capron, A., 1983, Enhancement of eosinophil effector function by soluble factors released by S. mansoni: Role of proteases, J. Immunol. 131: 464.PubMedGoogle Scholar
  6. Auriault, C., Joseph, M., Tartar, A., Bout, D., Tonnel, A. B., and Capron, A., 1984, Regulatory role of a tripeptide (TKP) from the second constant domain of immunoglobulin G, Int. J. Immunopharmacol. 7: 73.CrossRefGoogle Scholar
  7. Bach, M. K., Block, K. J., and Austen, K. F., 1971, IgE and IgGa antibody-mediated release of histamine from rat peritoneal cells. II. Interaction of IgGa and IgE at the target cell, J. Exp. Med. 133: 772.PubMedCrossRefGoogle Scholar
  8. Boltz-Nitulescu, G., and Spiegelberg, H. L., 1981, Receptors specific for IgE on rat alveolar and peritoneal macrophages, Cell. Immunol. 59: 106.PubMedCrossRefGoogle Scholar
  9. Boltz-Nitulescu, G., Bazin, H., and Spiegelberg, H. L., 1981, The specificity of Fc receptors for IgG2a/ IgG1/IgG2b and IgE on rat macrophages, J. Exp. Med. 154: 374.PubMedCrossRefGoogle Scholar
  10. Boltz-Nitulescu, G., Plummer, J. M., and Spiegelberg, H. L., 1982, Fc receptors for IgE on mouse macrophages and macrophage-like cell lines, J. Immunol. 128: 2265.PubMedGoogle Scholar
  11. Brostoff, J., Stanworth, D. R., and Johns, P., 1977, Immune complexes in atopy, Lancet 1: 741.CrossRefGoogle Scholar
  12. Butterworth, A. E., Sturrock, R. F., Houba, V., Mahmoud, A. A. F., Sher, A., and Rees, P. H., 1975, Eosinophils as mediators of antibody-dependent damage to schistosomula, Nature (London) 256: 727.CrossRefGoogle Scholar
  13. Butterworth, A. E., Remold, H. G., Houba, V., David, J. R., Franks, D., David, P. H., and Sturrock, R. F., 1977, Antibody-dependent eosinophil-mediated damage to 51Cr-labeled schistosomula of Schistosoma mansoni: Mediation by IgG and inhibition by antigen-antibody complexes, J. Immunol. 118: 2230.PubMedGoogle Scholar
  14. Capron, A., and Dessaint, J.-P., 1975, A role for IgE in protective immunity, IRCSJ. Med. Sci. 3: 477.Google Scholar
  15. Capron, A., Dessaint, J.-P., Capron, M., and Bazin, H., 1975, Specific IgE antibodies in immune adherence of normal macrophages to Schistosoma mansoni schistosomules, Nature (London) 253: 474.CrossRefGoogle Scholar
  16. Capron, A., Dessaint, J.-P., Joseph, M., Rousseaux, R., Capron, M., and Bazin, H., 1977a, Interaction between IgE complexes and macrophages in the rat: A new mechanism of macrophage activation. Eur. J. Immunol. 7: 315.PubMedCrossRefGoogle Scholar
  17. Capron, A., Dessaint, J.-P., Joseph, M., Torpier, G., Capron, M., Rousseaux, R., Santoro, F., and Bazin, H., 1977b, IgE and cells in schistosomiasis, Am. J. Trop. Med. Hyg. 26: 39.PubMedGoogle Scholar
  18. Capron, A., Dessaint, J.-P., Capron, M., Joseph, M., and Pestel, J., 1980, Role of anaphylactic antibodies in immunity to schistosomes, Am. J. Trop. Med. Hyg. 29: 849.PubMedGoogle Scholar
  19. Capron, A., Dessaint, J.-P., Capron, M., Joseph, M., and Torpier, G., 1982a, Effector mechanisms of immunity to schistosomes and their regulation, Immunol. Rev. 61: 41.PubMedCrossRefGoogle Scholar
  20. Capron, A., Dessaint, J.-P., Haque, A., and Capron, M., 1982b, Antibody-dependent cell-mediated cytotoxicity against parasites, Prog. Allergy 31: 234.Google Scholar
  21. Capron, A., Dessaint, J.-P., Capron, M., and Joseph, M., 1983a, IgE receptors on different cell lines and their role in triggering different immunological mechanisms, in: Proc. XII Congr. Eur. Acad. Allergy Clin. Immunol. ( U. Serafini and E. Errigo, eds.), pp. 17–24, O.I.C. Medical Press, Firenze.Google Scholar
  22. Capron, A., Dessaint, J.-P., Capron, M., and Joseph, M., 1983b, Effector mechanisms against schistosomes, in: Progress in Immunology V ( T. Tada, ed.), pp. 1305–1307, Academic Press, New York.Google Scholar
  23. Capron, M., Capron, A., Torpier, G., Bazin, H., Bout, D., and Joseph, M., 1978a, Eosinophil-dependent cytotoxicity in rat schistosomiasis: Involvement of IgG2a antibody and role of mast cells, Eur. J. Immunol. 8: 127.PubMedCrossRefGoogle Scholar
  24. Capron, M., Rousseaux, R., Mazingue, C., Bazin, H., and Capron, A., 1978b, Rat mast cell-eosinophil interaction in antibody-dependent eosinophil cytotoxicity to Schistosoma mansoni schistosomula, J. Immunol. 121: 2518.PubMedGoogle Scholar
  25. Capron, M., Torpier, G., and Capron, A., 1979, In vitro killing of S. mansoni schistosomula by eosinophils from infected rats: Role of cytophilic antibodies, J. Immunol. 123: 2220.PubMedGoogle Scholar
  26. Capron, M., Bazin, H., Joseph, M., and Capron, A., 1981a, Evidence for IgE-dependent cytotoxicity by rat eosinophils, J. Immunol. 126: 1764.PubMedGoogle Scholar
  27. Capron, M., Capron, A., Dessaint, J.-P., Johansson, S. G. O., and Prin, L., 1981b, Fc receptors for IgE on human and rat eosinophils, J. Immunol. 126: 2087.PubMedGoogle Scholar
  28. Capron, M., Capron, A., Goetzl, E. J., and Austen, K. F., 1981c, Tetrapeptides of the eosinophil chemotactic factor of anaphylaxis (ECF-A) enhance eosinophil Fc receptor, Nature (London) 289: 71.CrossRefGoogle Scholar
  29. Capron, M., Capron, A., Joseph, M., and Verwaerde, C., 1983, IgE receptors on phagocytic cells and immune response to schistosoma infection, Monogr. Allergy 18: 33.Google Scholar
  30. Capron, M., Nogueira-Queiroz, J. A., Papin, J. P., and Capron, A., 1984a, Interaction between eosinophils and antibodies: In vivo protective role against rat schistosomes, Cell. Immunol. 83: 60.PubMedCrossRefGoogle Scholar
  31. Capron, M., Spiegelberg, H. L., Prin, L., Bennich, H., Butterworth, A. E., Pierce, R. J., Ouaissi, M. A., and Capron, A., 1984b, Role of IgE receptors in effector function of human eosinophils, J. Immunol. 132: 462.PubMedGoogle Scholar
  32. Cardella, C. J., Davies, P., and Allison, A. C., 1974, Immune complexes induce selective release of lysosomal hydrolases from macrophages, Nature (London) 247: 46.CrossRefGoogle Scholar
  33. Cohn, Z., 1978, The activation of mononuclear phagocytes: Fact, fancy and function, J. Immunol. 121: 813.PubMedGoogle Scholar
  34. Dessaint, J.-P., 1982, Anaphylactic antibodies and their significance, Clin. Immunol. Allergy 2: 621.Google Scholar
  35. Dessaint, J.-P., Capron, A., Joseph, M., and Bazin, H., 1979a, Cytophilic binding of IgE to the macrophage. II. Immunologic release of lysosomal enzyme from macrophages by IgE in the rat: A new mechanism of macrophage activation, Cell. Immunol. 46: 24.PubMedCrossRefGoogle Scholar
  36. Dessaint, J.-P., Torpier, G., Capron, M., Bazin, H., and Capron, A., 1979b, Cytophilic binding of IgE to the macrophage. I. Binding characteristics of IgE on the surface of macrophages in the rat, Cell. Immunol. 46: 12.PubMedCrossRefGoogle Scholar
  37. Dessaint, J.-P., Waksman, B. H., Metzger, H., and Capron, A., 1980, Cytophilic binding of IgE to the macrophage. III. Involvement of cyclic GMP and calcium in macrophage activation by dimeric or aggregated rat myeloma IgE, Cell. Immunol. 51: 280.PubMedCrossRefGoogle Scholar
  38. Dessaint, J.-P., Capron, A., Joseph, M., Auriault, C., and Pestel, J., 1983, Macrophage-mediated IgE ADCC to helminth parasites and IgE-dependent macrophage activation, in: Macrophage Mediated Antibody-Dependent Cellular Cytotoxicity ( H. S. Koren, ed.), pp. 315–338, Dekker, New York.Google Scholar
  39. Dessein, A. J., Parker, W. L., James, S. L., and David, J. R., 1981, IgE antibody and resistance to infection. I. Selective suppression of the IgE antibody response in rats diminishes the resistance and the eosinophil response to T. spiralis infection, J. Exp. Med. 153: 423.Google Scholar
  40. Durack, D. T., Sumi, S. M., and Klebanoff, S. J., 1976, Neurocytotoxicity of human eosinophils, Proc. Natl. Acad. Sci. USA 73: 1443.Google Scholar
  41. Fewtrell, C., and Metzger, H., 1980, Larger oligomers of IgE are more effective than dimers in stimulating rat basophil leukemia cells, f. Immunol. 125: 701.Google Scholar
  42. Finbloom, D. S., and Metzger, H., 1982, Binding of immunoglobulin E to the receptor on rat peritoneal macrophages, J. Immunol. 129: 2004.Google Scholar
  43. Finbloom, D. S., and Metzger, H., 1983, Isolation of cross-linked IgE-receptor complexes from rat macrophages, J. Immunol. 130: 1489.PubMedGoogle Scholar
  44. Frigas, E., Loegzring, D. A., and Gleich, G. J., 1980, Cytotoxic effects of the guinea pig eosinophil major basic protein on tracheal epithelium, Lab. Invest. 42: 35.Google Scholar
  45. Fujita, Y., Rubinstein, E., Greco, D. B., Reisman, R. E., and Arbesman, C. E., 1975, Antigen-antibody complexes in or on eosinophils in nasal secretions, Int. Arch. Allergy Appl. Immunol. 48: 577.PubMedCrossRefGoogle Scholar
  46. Grzych, J. M., Capron, M., Bazin, H., and Capron, A., 1982, In vitro and in vivo effector function of rat IgG2a monoclonal anti-S. mansoni antibodies, J. Immunol. 129: 2739.PubMedGoogle Scholar
  47. Grzych, J. M., Capron, M., Dissous, C., and Capron, A., 1984, Blocking activity of rat monoclonal antibodies in experimental schistosomiasis, J. Immunol. 133: 998.PubMedGoogle Scholar
  48. Halper, J., and Metzger, H., 1976, The interaction of IgE with rat basophilic leukemia cells. VI. Inhibition by IgGa immune complexes, Immunochemistry 13: 907.PubMedCrossRefGoogle Scholar
  49. Hsu, J. Y. L., Lust, G. L., and Hsii, H. F., 1971, The fate of challenge schistosome cercariae in a monkey immunized by cercariae exposed to high doses of X-irradiation, Proc. Soc. Exp. Biol. Med. 136: 727.PubMedCrossRefGoogle Scholar
  50. Hubscher, T., 1975, Role of the eosinophil in the allergic reactions. I. EDI, an eosinophil derived inhibitor of histamine release, J. Immunol. 114: 1379.PubMedGoogle Scholar
  51. Ishikawa, T., Wicher, K., and Arbesman, C. E., 1974, In vitro and in vivo studies on uptake of antigen-antibody complexes by eosinophils, Int. Arch. Allergy Appl. immunol. 46: 230.PubMedCrossRefGoogle Scholar
  52. Joseph, M., Dessaint, J.-P., and Capron, A., 1977, Characteristics of macrophage cytotoxicity induced by IgE immune complexes, Cell. Immunol. 34: 247.PubMedCrossRefGoogle Scholar
  53. Joseph, M., Capron, A., Butterworth, A. E., Sturrock, R. F., and Houba, V., 1978, Cytotoxicity of human and baboon mononuclear phagocytes against schistosomula in vitro: Induction by immune complexes containing IgE and Schistosoma mansoni antigens, Clin. Exp. Immunol. 33: 48.Google Scholar
  54. Joseph, M., Tonnel, A., Capron, A., and Voisin, C., 1980, Enzyme release and superoxide anion production by human alveolar macrophages stimulated with immunoglobulin E, Clin. Exp. Immunol. 40: 416.Google Scholar
  55. Joseph, M., Tonnel, A. B., Capron, A., and Dessaint, J.-P., 1981, The interaction of IgE antibody with human alveolar macrophages and its participation in the inflammatory processes of lung allergy, Agents Actions 11: 619.PubMedCrossRefGoogle Scholar
  56. Joseph, M., Tonnel, A. B. T., Torpier, G., Capron, A., Arnoux, B., and Benveniste, J., 1983, Involvement of immunoglobulin E in the secretory processes of alveolar macrophages from asthmatic patients, J. Clin. Invest. 71: 221.PubMedCrossRefGoogle Scholar
  57. Kagey-Sobotka, A., Dembo, M., Goldstein, B., Metzger, H., and Lichtenstein, L. M., 1981, Qualitative characteristics of histamine release from human basophils by covalently cross-linked IgE dimers and trimers, J. Immunol. 127: 2285.PubMedGoogle Scholar
  58. Khalife, J., Capron, M., Grzych, J. M., Bazin, H., and Capron, A., 1985, Extracellular release of rat eosinophil peroxidase (EPO). I. Role of anaphylactic immunoglobulins, J. Immunol. 134: 1968.PubMedGoogle Scholar
  59. Lawrence, D. A., Weigle, W. D., and Spiegelberg, H. L., 1975, Immunoglobulins cytophilic for human lymphocytes, monocytes, and neutrophils, J. Clin. Invest. 55: 368.PubMedCrossRefGoogle Scholar
  60. Lee, W. T., and Conrad, D. H., 1984, The murine lymphocyte receptor for IgE. II. Characterization of the multivalent nature of the B lymphocyte receptor for IgE, J. Exp. Med. 152: 1790.CrossRefGoogle Scholar
  61. Lopez, A. F., Strath, M., and Sanderson, C. J., 1983, Mouse immunoglobulin isotypes mediating cytotoxicity of target cells by eosinophils and neutrophils, Immunology 48: 503.PubMedGoogle Scholar
  62. McEvoy, J. D. S., Donald, K. J., and Edwards, P. L., 1978, Immunoglobulin level and electron microscopy in eosinophil pneumonia, Am. J. Med. 64: 529.PubMedCrossRefGoogle Scholar
  63. McKean, J. R., and Anwar, A. R. E., 1981, Schistosoma mansoni: Complement and antibody damage mediated by human eosinophils and neutrophils, in killing schistosomula in vitro, Exp. Parasitol. 51: 307.Google Scholar
  64. McKeever, P. E., and Spicer, S. S., 1980, Surface receptors of mononuclear phagocytes, in: The Reticuloendothelial System, Volume 1, Morphology ( I. Carr and W. T. Daems, eds.), pp. 161–258, Plenum Press, New York.Google Scholar
  65. McLaren, D. J., and Ramalho-Pinto, F. J., 1979, Eosinophil-mediated killing of schistosomula of S. mansoni in vitro: Synergistic effect of antibody and complement, J. Immunol. 123: 327.Google Scholar
  66. Mehta, K., Sindhu, R. K., Subrahmanyam, D., and Nelson, D. S., 1980, IgE-dependent adherence and cytotoxicity of rat spleen and peritoneal cells to Litomosoides carinii microfilaria, Clin. Exp. Immunol 41: 107.Google Scholar
  67. Melewicz, F. M., and Spiegelberg, H. L., 1980, Fc receptors for IgE on a subpopulation of human peripheral blood monocytes, J. Immunol. 125: 1026.PubMedGoogle Scholar
  68. Melewicz, F. M., Zeiger, R. S., Mellon, M. H., O’Connor, R. D., and Spiegelberg, H. L., 1981a, Increased peripheral blood monocytes with Fc receptors for IgE in patients with severe allergic disorders, J. Immunol. 126: 1592.PubMedGoogle Scholar
  69. Melewicz, F. M., Zeiger, R. S., Mellon, M. H., O’Connor, R. D., and Soiegelberg, H. L., 1981b, Increased IgE-dependent cytotoxicity by blood mononuclear cells of allergic patients, Clin. Exp. Immunol. 43: 526.Google Scholar
  70. Melewicz, F. M., Kline, L. E., Cohen, A. B., and Spiegelberg, H. L., 1982a, Characterization of Fc receptors for IgE on human alveolar macrophages, Clin. Exp. Immunol. 49: 364.Google Scholar
  71. Melewicz, F. M., Plummer, J. M., and Spiegelberg, H. L., 1982b, Comparison of the Fc receptors for IgE on human lymphocytes and monocytes, J. Immunol. 129: 563.PubMedGoogle Scholar
  72. Metzger, H., 1978, The IgE-mast cell system as a paradigm for the study of antibody mechanisms, Immunol. Rev. 41: 187.CrossRefGoogle Scholar
  73. Parillo, J. E., and Fauci, A. S., 1978, Human eosinophils: Purification and cytotoxic capability of eosinophils from patients with the hypereosinophilic syndrome, Blood 51: 457.Google Scholar
  74. Perez, H., and Smithers, S. R., 1977, Schistosoma mansoni in the rat: The adherence of macrophages to schistosomula in vitro after sensitization with immune serum, Int. J. Parasitol. 7: 315.PubMedCrossRefGoogle Scholar
  75. Pestel, J., Dessaint, J.-P., Joseph, M., Bazin, H., and Capron, A., 1984a, Macrophage triggering by aggregated immunoglobulins. II. Comparison of IgE and IgG aggregates or immune complexes, Clin. Exp. Immunol. 57: 404.Google Scholar
  76. Prin, L., Capron, M., Tonnel, A. B., Bletry, O., and Capron, A., 1983, Heterogeneity of human peripheral blood eosinophils: Variability in cell density and cytotoxic ability in relation to the level and origin of hypereosinophilia, Int. Arch. Allergy Appl. Immunol. 72: 336.PubMedCrossRefGoogle Scholar
  77. Prin, L., Capron, M., Gosset, P., Kustniez, J. P., Bletry, O., Tonnel, A. B., and Capron, A., 1986, Eosinophilic lung disease: Immunological studies of blood and alveolar eosinophils, Clin. Exp. Immunol. 63: 249–257.Google Scholar
  78. Rabinovitch, M., Manejias, R. E., and Nussenzweig, V., 1975, Selective phagocytic paralysis induced by immobilized immune complexes, J. Exp. Med. 142: 827.PubMedCrossRefGoogle Scholar
  79. Ramalho-Pinto, F. J. D., McLaren, D. J., and Smithers, S. R., 1978, Complement-mediated killing of schistosomula of Schistosoma mansoni by rat eosinophils in vitro, J. Exp. Med. 147: 147.PubMedCrossRefGoogle Scholar
  80. Ramalho-Pinto, F. J. D., De Rossi, R., and Smithers, S. R., 1979, Murine Schistosoma mansoni anti-schistosomula antibodies and the IgG subclasses involved in the complement and eosinophil-mediated killing of schistosomula in vitro, Parasite Immunol. 1: 295.PubMedCrossRefGoogle Scholar
  81. Rankin, J. A., Hitchcock, M., Merrill, W. W., Bach, M. K., Brashler, J. R., and Askenase, P. W., 1982, IgE-dependent release of leukotriene C4 from alveolar macrophages, Nature (Eondon) 297: 329.CrossRefGoogle Scholar
  82. Rankin, J. A., Hitchcock, M., Merrill, W. W., Huang, S. S., Brashler, J. R., Bach, M. K., and Askenase, P. W., 1984, IgE immune complexes induce immediate and prolonged release of leukotriene C4 (LTC4) from rat alveolar macrophages, J. Immunol. 132: 1993.Google Scholar
  83. Rouzer, C. A., Scott, W. A., Hamill, A. L., Liu, F.-T., Katz, D. H., and Cohn, Z. A., 1982a, IgE immune complexes stimulate arachidonic acid release by mouse peritoneal macrophages, Proc. Natl. Acad. Sci. USA 79: 5656.PubMedCrossRefGoogle Scholar
  84. Rouzer, C. A., Scott, W. A., Hamill, A. L., Liu, F.-T., Katz, D. H., and Cohn, Z. A., 1982b, Secretion of leukotriene C and other arachidonic acid metabolites by macrophages challenged with immunoglobulin E immune complexes, J. Exp. Med. 156: 1077.PubMedCrossRefGoogle Scholar
  85. Santoro, F., Capron, M., Joseph, M., Rousseaux-Prevost, R., and Capron, A., 1978, Circulating antigens and immune compkxes in Schistosoma mansoni-infected rats: Characterization by radioimmunoprecipitation-PEG assay (RIPEGA), Clin. Exp. Immunol. 32: 435.Google Scholar
  86. Segal, D. M., Taurog, J. D., and Metzger, H., 1977, Dimeric immunoglobulin E serves as a unit signal for mast cell degranulation, Proc. Natl. Acad. Sci. USA 74: 2993.PubMedCrossRefGoogle Scholar
  87. Spiegelberg, H. L., Boltz-Nitulescu, G., Plummer, J. M., and Melewicz, F. M., 1983, Characterization of the IgE Fc receptors on monocytes and macrophages, Fed. Proc. 42: 124.Google Scholar
  88. Spry, C. J. F., 1980, Eosinophilia and hypereosinophilic syndrome, Trans. R. Soc. Trop. Med. Hyg. 74 (Suppl.): 3.CrossRefGoogle Scholar
  89. Stevens, W. J., and Bridts, C. H., 1984, IgG-containing and IgE-containing circulating immune complexes in patients with asthma and rhinitis, J. Allergy Clin. Immunol. 73: 276.PubMedCrossRefGoogle Scholar
  90. Stevens, W. J., Feldmeier, H., Bridts, C. H., and Daffalla, A. A., 1983, IgG and IgE circulating immune complexes, total serum IgE and parasite related IgE in patients with mono- or mixed infection with Schistosoma mansoni and/or S. haematobium: Influence of therapy, Clin. Exp. Immunol. 52: 142.Google Scholar
  91. Takenaka, P., Okuda, M., Kawabori, S., and Kubo, K., 1977, Extracellular release of peroxidase from eosinophils by interaction with immune complexes, Clin. Exp. Immunol. 28: 56.PubMedGoogle Scholar
  92. Tonnel, A. B., Joseph, M., Gosset, P., and Fournier, E., 1983, Stimulation of alveolar macrophages in asthmatic patients after local provocation test, Lancet 1: 1406.PubMedCrossRefGoogle Scholar
  93. Von Lichtenberg, F., Sher, A., Gibbons, N., and Doughty, B. L., 1976, Eosinophil-enriched inflammatory response to schistosomula in the skin of mice immune to Schistosoma mansoni infection in mice, Am. J. Path. 84: 479.PubMedGoogle Scholar
  94. Zodda, R. M., and Phillips, S. M., 1982, Monoclonal antibody-mediated protection against Schistosoma mansoni infection in mice, J. Immunol. 129: 2326.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Jean-Paul Dessaint
    • 1
    • 2
  • André Capron
    • 1
    • 2
  1. 1.Centre d’Immunologie et de Biologie ParasitaireINSERM U-167Lille CedexFrance
  2. 2.Institut PasteurCNRS 624Lille CedexFrance

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