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Structure and Expression of IgE Receptors

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The Reticuloendothelial System

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Abstract

Cell surface receptors with high affinity for IgE are present only on mast cells, basophils, and neoplastic counterparts of these cells. Monomeric IgE is bound to these receptors and displayed on the mast cell/basophil surface. Subsequently, multivalent antigen may bind to adjacent receptor-bound IgE molecules. The primary role of these IgE receptors appears to be transducing this cross-linking signal in order to initiate mediator release. The specificity of these IgE receptors (or Fcε receptors) on basophils for IgE was first shown in studies with human peripheral blood leukocytes (Ishizaka et al., 1970; Sullivan et al., 1971). More detailed studies of the structure, function, and expression of the high-affinity Fcε receptors have been made possible by use of the rat basophilic leukemia (RBL) cell line (Kulczycki et al., 1974).

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Authors and Affiliations

  1. Department of Internal Medicine, Division of Allergy and Immunology, Washington University School of Medicine, St. Louis, Missouri, 63110, USA

    Anthony Kulczycki Jr.

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  1. Anthony Kulczycki Jr.
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Editors and Affiliations

  1. University of South Florida, Tampa, Florida, USA

    Herman Friedman

  2. Medical College of Virginia, Richmond, Virginia, USA

    Mario R. Escobar

  3. Medical College of Georgia, Augusta, Georgia, USA

    Sherwood M. Reichard

  4. The University of Pennsylvania, Philadelphia, Pennsylvania, USA

    S. Michael Phillips

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© 1986 Plenum Press, New York

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Kulczycki, A. (1986). Structure and Expression of IgE Receptors. In: Friedman, H., Escobar, M.R., Reichard, S.M., Phillips, S.M. (eds) The Reticuloendothelial System. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5158-0_4

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  • DOI: https://doi.org/10.1007/978-1-4684-5158-0_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5160-3

  • Online ISBN: 978-1-4684-5158-0

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