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Macrophages in Immunoparasitology

  • Graham F. Mitchell
  • Paul R. Wood

Abstract

The discussion herein on macrophage activities in the immunology of host-parasite relationships is selective. It embraces a range of topics that can be termed, in the broadest sense, “extracellular macrophage-related events” in the immunology of parasitism and, in particular, rodent parasitic infections. Aspects of the cell biology of recognition, entry, persistence, and intramacrophage destruction or inhibition of parasitic protozoa will not be covered, reviews on these topics being plentiful (e.g., Trager, 1974; Jones, 1974, 1981; Smith, 1979; Chang, 1981; Mauel, 1982; Sethi, 1982; Bray, 1982; Edelson, 1982; Pearson et al., 1983). Phagocytosis will only be covered in outline. Rather, attention will focus on the macrophage in, or from, parasitized hosts as a regulator of antiparasite immune responses and as an effector cell of host resistance involving mediator release. Large sections in the review cover two aspects that are research interests of the authors, viz., the immunoregulatory role of parasitized macrophages in murine cutaneous leishmaniasis and the role of macrophage products in the control of infection with plasmodia and related intraerythrocytic protozoa. Experimental results are detailed in these two sections more as an indication of approaches currently being pursued and certainly not to indicate that a clear picture currently exists.

Keywords

Cutaneous Leishmaniasis Toxoplasma Gondii Trypanosoma Cruzi Schistosoma Mansoni Infected Macrophage 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Graham F. Mitchell
    • 1
  • Paul R. Wood
    • 2
  1. 1.Immunoparasitology UnitThe Walter and Eliza Hall Institute of Medical ResearchMelbourneAustralia
  2. 2.Department of MicrobiologyUniversity of MelbourneParkvilleAustralia

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