The Nephritogenic Immune Response and Renal Immunopathogenesis

A Progress Report
  • Michael D. Clayman
  • Carl S. Goldstein
  • Eric G. Neilson


It is generally agreed that the immune system plays a central role in many forms of renal injury. Hallmark studies of Dixon et al. (1961) emphasized the importance of antibodies and immune complex deposition in glomerular disease processes. A wealth of data have subsequently accumulated which lend support to the concept that humoral immunity is an intrinsic component of many nephritogenic immune responses. The conceptual framework for understanding renal immunology, as a result, has been largely defined in terms of antibody production, renal deposition, and subsequent immune amplification processes.


Immune Complex Glomerular Basement Membrane Interstitial Nephritis Brown Norway Immune Complex Deposition 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Michael D. Clayman
    • 1
  • Carl S. Goldstein
    • 1
  • Eric G. Neilson
    • 1
  1. 1.Renal Electrolyte Section, Department of MedicineUniversity of Pennsylvania School of MedicinePhiladelphiaUSA

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