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Leukotrienes

  • Michael K. Bach

Abstract

Slow-reacting substance of anaphylaxis (SRS-A) has been known for over 40 years and has been suspected to play an important role in the symptomatology of asthma for a major part of that time. There has been a virtual explosion of interest in this substance and in some of the chemically related molecules in the 5 years or so which have passed since the structures of the leukotrienes were established and since their chemical synthesis made them more readily available. This has led to detailed studies of the actions of the leukotrienes and to the discovery of their actions on various smooth muscle preparations. In addition, many other activities, both in vitro and in vivo, which may be linked to asthma and to other inflammatory conditions have been recognized.

Keywords

Arachidonic Acid Human Polymorphonuclear Leukocyte Lipoxygenase Product Smooth Muscle Preparation Slow React Substance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Michael K. Bach
    • 1
  1. 1.Department of Hypersensitivity Diseases ResearchThe Upjohn CompanyKalamazooUSA

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