Macrophage Procoagulants, Fibrin Deposition, and the Inflammatory Response

  • Richard L. Edwards
  • Veeta A. Ewan
  • Frederick R. Rickles


In 1938, Menkin provided a comprehensive view of the inflammatory response: “Inflammation may be broadly defined as the complex vascular, lymphatic, and local tissue reaction elicited in higher animals by the presence of microorganisms or of nonviable irritants. It represents a basic reaction to injury, in which the deleterious agent tends to be localized and ultimately destroyed.” Menkin characterized several phases in the development of the inflammatory lesion beginning with increased fluid passage through the capillary endothelial wall and the formation of a fibrinous network which immobilizes the irritant. The lesion is then completed by the development of local thrombi, occlusion of draining lymphatics, and subsequent infiltration of leukocytes. Menkin proposed that the early fixation of the irritant allowed an interval during which leukocytes could assemble for the purpose of phagocytosis. Furthermore, these three phases—local fluid influx, fixation in a focal fibrinous meshwork, and progressive leukocyte infiltration—represent a necessary prelude to the development of immunity.


Blood Coagulation Tissue Factor Disseminate Intravascular Coagulation Fibrin Deposition Procoagulant Activity 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Richard L. Edwards
    • 1
    • 2
  • Veeta A. Ewan
    • 1
    • 2
  • Frederick R. Rickles
    • 1
    • 2
  1. 1.Department of MedicineUniversity of Connecticut School of MedicineFarmingtonUSA
  2. 2.Veterans Administration Medical CenterNewingtonUSA

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