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The Prenatal Diagnosis of the Fragile X Syndrome

  • Edmund C. Jenkins
  • W. Ted Brown

Abstract

That an excess of males are affected with nonspecific mental retardation has been known for some time. Penrose (1938) noted that there were more mentally retarded institutionalized males than females. Although Martin and Bell (1943) and Renpenning et al. (1962) described families with characteristic X-linked pedigrees and Davison (1973) suggested that the cause of nonspecific mental retardation (MR) may be due to an X-linked etiology, it was Lehrke (1972) and Turner and Turner (1974) who underlined the significance of X-linkage by concluding that it may be the reason for nonspecific MR in 20% or more of affected males.

Keywords

Mental Retardation Prenatal Diagnosis Fragile Site Induction System Infantile Autism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Aubrey Milunsky 1986

Authors and Affiliations

  • Edmund C. Jenkins
    • 1
  • W. Ted Brown
    • 2
  1. 1.Department of Cytogenetics, Institute for Basic ResearchNew York State Office of Mental Retardation and Developmental DisabilitiesStaten IslandUSA
  2. 2.Department of Human Genetics, Institute for Basic ResearchNew York State Office of Mental Retardation and Developmental DisabilitiesStaten IslandUSA

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