Amniotic Fluid

  • Louis Dallaire
  • Michel Potier


The chemical constituents of amniotic fluid, which acts as a protective physical “cushion” for the fetus, have yielded valuable information for prenatal diagnosis, allowing increasingly accurate assessment of fetal physiology and metabolism. Since the amniotic fluid can be viewed as an extension of the fetal extracellular space (Lind et al., 1969; Lind and Hytten, 1970), an understanding of its origin, formation, and chemical constitution is crucial to continued progress in prenatal diagnosis and fetal therapy. Cellular components are discussed in this chapter and in Chapter 4.


Amniotic Fluid Prenatal Diagnosis Congenital Adrenal Hyperplasia Maternal Serum Fetal Serum 
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  1. Abbas, T. M., and Tovey, J. E., 1960, Proteins in liquor amnii, Br. Med. J. 1:476.PubMedCrossRefGoogle Scholar
  2. Abramovich, D. R., 1968, The volume of amniotic fluid in early pregnancy, J. Obstet. Gynaecol. Br. Commonw. 75:728.PubMedCrossRefGoogle Scholar
  3. Abramovich, D. R., 1970, Fetal factors influencing the volume and composition of liquor amnii, J. Obstet. Gynaecol. Br. Commonw. 77:865.PubMedCrossRefGoogle Scholar
  4. Abramovich, D. R., Herriot, R., and Stott, J., 1983, Dihydrotestosterone levels at midpregnancy and term: A comparison with testosterone concentrations, J. Obstet. Gynaecol. Br. Commonw. 90:232.CrossRefGoogle Scholar
  5. Abramsky, O., Brenner, T., Lisak, R. P., et al., 1979, Significance in neonatal myasthenia gravis of inhibitory effect of amniotic fluid on binding of antibodies to acetylcholine receptor, Lancet 2:1333.PubMedCrossRefGoogle Scholar
  6. Anteby, S. C., Zukerman, H., Gedelia, I., et al., 1973, Citric acid in amniotic fluid, J. Obstet. Gynaecol. Br. Commonw. 80:27.PubMedCrossRefGoogle Scholar
  7. Antonowicz, I., Chang, S. K., and Grand, R. J., 1974, Development and distribution of lysosomal enzymes and disaccharidases in human fetal intestine, Gastroenterology 67:51.PubMedGoogle Scholar
  8. Antonowicz, I., Ishida, S., and Shwachman, H., 1975, Studies in meconium from cystic fibrosis patients and controls, Pediatrics 56:782.PubMedGoogle Scholar
  9. Antonowicz, I., Milunsky, A., Lebenthal, E., et al., 1977, Disaccharidase and lysosomal enzyme activities in amniotic fluid, intestinal mucosa and meconium, Biol. Neonate 32:280.PubMedCrossRefGoogle Scholar
  10. Antonowicz, I., Lebenthal, E., and Shwachman, H., 1978, Disaccharidase activities in small intestinal mucosa in patients with cystic fibrosis, Pediatrics 92:214.CrossRefGoogle Scholar
  11. Appelbaum, P. C., Shulman, G., Chambers, N. L., et al., 1980, Studies on the growth-inhibiting property of amniotic fluids from two United States population groups, Am. J. Obstet. Gynecol. 137:579.PubMedGoogle Scholar
  12. Arcilla, M. B., and Sturgeon, P., 1972, Lewis and ABH substances in amniotic fluid obtained by amniocentesis, Pediatr. Res. 6:853.PubMedCrossRefGoogle Scholar
  13. Arey, L. B., 1965, Developmental Anatomy: A Textbook and Laboratory Manual of Embryology, 7th ed., Saunders, Philadelphia.Google Scholar
  14. Arvidson, G., Ekelund, H., and Astedt, B., 1972, Phospholipid composition of human amniotic fluid during gestation and at term, Acta Obstet. Gynecol. Scand. 51:71.PubMedCrossRefGoogle Scholar
  15. Auger, P., Marquis, G., Dallaire, L., et al., 1980a, Stunted growth of Candida albicans in human amniotic fluid in vitro, J. Lab. Clin. Med. 95:272.PubMedGoogle Scholar
  16. Auger, P., Marquis, G., Dallaire, L., et al., 1980b, Natural occurrence of a humoral response to Candida in human amniotic fluid, Am. J. Obstet. Gynecol. 136:1075.PubMedGoogle Scholar
  17. Auricchio, S., Rubino, A., and Murset, G., 1965, Intestinal glycosidase activities in the human embryo, fetus and newborn, Pediatrics 35:944.PubMedGoogle Scholar
  18. Bacigalupo, G., and Meraner, R., 1984, Pyruvate kinase in human amniotic fluid: A new indicator of fetal maturity in late pregnancy, J. Perinat. Med. 12:97.PubMedCrossRefGoogle Scholar
  19. Bala, R. M., Wright, C., Bardai, A., et al., 1978, Somatomedin bioactivity in serum and amniotic fluid during pregnancy, J. Clin. Endocrinol. Metab. 46:649.PubMedCrossRefGoogle Scholar
  20. Barbanti, A., 1956, Il quadro proteico de liquido amniotico valutato elettroforeticamenti e suoi rapporti col siero materno e quello fetale, Minerva Ginecol. 8:708.PubMedGoogle Scholar
  21. Behrman, R. E., Parer, J. T., and de Lannoy, C. W., 1967, Placental growth and the formation of amniotic fluid, Nature 214:678.PubMedCrossRefGoogle Scholar
  22. Belisle, S., Fencl, M. de M., and Tulchinsky, E., 1977, Amniotic fluid testosterone and follicle-stimulating hormone in the determination of fetal sex, Am. J. Obstet. Gynecol. 128:514.PubMedGoogle Scholar
  23. Belisle, S., Fencl, M. de M., Osathanondh, R., et al., 1978, Sources of 17 alpha-hydroxypregnenolone and its sulfate in human pregnancy, J. Clin. Endocrinol. Metab. 46:721.PubMedCrossRefGoogle Scholar
  24. Benirschke, K., and McKay, D. C., 1953, The antidiuretic hormone in fetus and infant, Obstet. Gynecol. 1:638.PubMedGoogle Scholar
  25. Ben-Jonathan, N., and Munsick, R. A., 1980, Dopamine and prolactin in human pregnancy, J. Clin. Endocrinol. Metab. 51:1019.PubMedCrossRefGoogle Scholar
  26. Benzie, R. J., and Doran, T. A., 1975, The fetoscope. A new clinical tool for prenatal genetic diagnosis, Am. J. Obstet. Gynecol. 121:460.PubMedGoogle Scholar
  27. Benzie, R. J., Doran, T. A., Harkins, J. L., et al., 1974, Composition of the amniotic fluid and maternal serum in pregnancy, Am. J. Obstet. Gynecol. 119:798.PubMedGoogle Scholar
  28. Bergman, N., Bercovici, B., and Sacks, T., 1972, Antibacterial activity of human amniotic fluid, Am. J. Obstet. Gynecol. 114:520.PubMedGoogle Scholar
  29. Bernard, B., Barton, L., Abate, M., et al., 1977a, Maternal-fetal transfer of cefazolin in the first twenty weeks of pregnancy, J. Infect. Dis. 136:377.PubMedCrossRefGoogle Scholar
  30. Bernard, B., Thielen, P., Garcia-Cazares, J., et al., 1977b, Maternal-fetal pharmacology of cefatrizine in the first 20 weeks of pregnancy, Antimicrob. Agents Chemother. 12:231.PubMedGoogle Scholar
  31. Bernier, G. M., and Fanger, M. W., 1972, Synthesis of ß2-microglobulin by stimulated lymphocytes, J. Immunol. 109:407.PubMedGoogle Scholar
  32. Bhatt, R. V., Acharya, P. T., Hazra, M. N., et al., 1978, Estimation of the volume of liquor in second trimester, Ind. J. Med. Res. 61:161.Google Scholar
  33. Biezenski, J. J., 1973, Amniotic fluid phospholipids in early gestation, Obstet. Gynecol. 41:825.PubMedGoogle Scholar
  34. Biezenski, J. J., 1976, Incorporation of 14I-palmitate into rabbits’ fetal lipids in vivo, Am. J. Obstet. Gynecol. 126:356.PubMedGoogle Scholar
  35. Biezenski, J. J., Pomerance, W., and Goodman, J., 1968, Studies on the origin of amniotic fluid lipids, Am. J. Obstet. Gynecol. 102:853.PubMedGoogle Scholar
  36. Blanco, J. D., Gibbs, R. S., Krebs, L. F., et al., 1982, The association between the absence of amniotic fluid bacterial inhibitory activity and intra-amniotic infection, Am. J. Obstet. Gynecol. 143:749.PubMedGoogle Scholar
  37. Blankstein, J., Kraiem, Z., Mashiah, S., et al., 1979, Effect of dexamethasone administration at midgesta-tion on Cortisol levels in amniotic fluid, Isr. J. Med. Sci. 15:945.PubMedGoogle Scholar
  38. Blumenfeld, T. A., Driscoll, J. M., and James, L. S., 1974, Lecithin/sphingomyeline ratios in tracheal and pharyngeal aspirates in respiratory distress syndrome, J. Pediatr. 85:403.PubMedCrossRefGoogle Scholar
  39. Borer, R. C., Jr., Gluck, L., Freeman, R. K., et al., 1971, Prenatal prediction of the respiratory distress syndrome (RDS), Pediatr. Res. 5:655 (abstract).Google Scholar
  40. Borresen, A. L., and Van der Hagen, C. B., 1973, Metachromatic leukodystrophy. II. Direct determination of arylsulfatase A activity in amniotic fluid, Clin. Genet. 4:442.PubMedCrossRefGoogle Scholar
  41. Boulley, A. M., Vial, M., Bessis, R., et al., 1984, Antenatal diagnosis of 2 cases of cytomegalic inclusion disease, Arch. Fr. Pediatr. 41 (2): 123.PubMedGoogle Scholar
  42. Bourne, G. L., 1962, The Human Amnion and Chorion, Lloyd-Luke, London.Google Scholar
  43. Bourne, G. L., 1966, The anatomy of the human amnion and chorion, Proc. R. Soc. Med. 59:1127.PubMedGoogle Scholar
  44. Bourne, G. L., and Lacy, D., 1960, Ultra-structure of human amnion and its possible relation to the circulation of amniotic fluid, Nature 186:952.PubMedCrossRefGoogle Scholar
  45. Bratlid, D., and Lindback, T., 1978, Bacteriolytic activity of amniotic fluid, Obstet. Gynecol. 51:63.PubMedGoogle Scholar
  46. Briand, R. L., Harold, S., and Blass, K. G., 1981, High-performance liquid chromatographic determination of the lecithin/sphingomyelin ratio in amniotic fluid, J. Chromatog. 223:211.Google Scholar
  47. Brock, D. J. H., 1983, Amniotic fluid alkaline phosphatase isoenzymes in early prenatal diagnosis of cystic fibrosis, Lancet 2:941.PubMedCrossRefGoogle Scholar
  48. Brock, D. J. H., Bedgood, D., and Hayward, C., 1984, Amniotic fluid microvillar enzyme activities in the early detection of fetal abnormalities, Prenat. Diagn. 4:261.PubMedCrossRefGoogle Scholar
  49. Brocklehurst, D., and Wilde, C. E., 1980, Amniotic fluid alkaline phosphatase, gamma-glutamyl transferase and 5′-nucleotidase activity from 13–40 weeks gestation as an index of fetal lung maturity, Clin. Chem. 26:588.PubMedGoogle Scholar
  50. Brzezinski, A., Sadovsky, E., and Shafrir, E., 1961, Electrophoretic distribution of proteins in amniotic fluid and in maternal and fetal serum, Am. J. Obstet. Gynecol. 82:800.PubMedGoogle Scholar
  51. Brzezinski, A., Sadovsky, E., and Shafrir, E., 1964, Protein composition of early amniotic fluid and fetal serum with a case of bis-albuminaemia, Am. J. Obstet. Gynecol. 89:488.PubMedGoogle Scholar
  52. Burdett, P., Lizana, J., Eneroth, P., et al., 1982, Proteins of human amniotic fluid. II. Mapping by two-dimensional electrophoresis, Clin. Chem. 28:935.PubMedGoogle Scholar
  53. Butterworth, J., Sutherland, G. R., Bain, A. D., et al., 1972, Lysosomal enzymes in amniotic fluid, Clin. Chim. Acta 39:275.PubMedCrossRefGoogle Scholar
  54. Butterworth, J., Broadhead, D. M., Sutherland, G. R., et al., 1974, Lysosomal enzymes of amniotic fluid in relation to gestational age, Am. J. Obstet. Gynecol. 119:821.PubMedGoogle Scholar
  55. Cantarow, A., Stuckert, H., and Davies, R. C., 1933, Chemical composition of amniotic fluid; comparative study of human amniotic fluid and maternal blood, Surg. Gynecol. Obstet. 57:63.Google Scholar
  56. Carbarns, N. J. B., Gosden, C., and Brock, D. J. H., 1983, Microvillar peptidase activity in amniotic fluid: Possible use in the prenatal diagnosis of cystic fibrosis, Lancet 1:329.PubMedCrossRefGoogle Scholar
  57. Carson, D. J., Okuno, A., Lee, P. A., et al., 1982, Amniotic fluid steroid levels, Am. J. Dis. Child 136:218.PubMedGoogle Scholar
  58. Caspi, E., Schreyer, I., Schreyer, P., et al., 1975a, Amniotic fluid volume, total phospholipids concentration and L/S ratio in term pregnancies, Obstet. Gynecol. 46:584.PubMedGoogle Scholar
  59. Caspi, E., Schreyer, P., and Tamir, I., 1975b, The amniotic fluid foam test, L/S ratio, and total phospholipids in the evaluation of fetal lung maturity, Am. J. Obstet. Gynecol. 122:323.PubMedGoogle Scholar
  60. Caspi, E., Schreyer, P., Weinraub, Z., et al., 1975c, Changes in amniotic fluid lecithin-sphingomyelin ratio following maternal dexamethasone administration, Am. J. Obstet. Gynecol. 122:327.PubMedGoogle Scholar
  61. Cassady, G., Hinkley, C., Bailey, P., et al., 1975, Amniotic fluid creatinine in pregnancies complicated by diabetes, Am. J. Obstet. Gynecol. 122:13.PubMedGoogle Scholar
  62. Cassell, G. H., Davis, R. O., Waites, K. B., et al., 1983, Isolation of Mycoplasma hominis and Ureaplasma urealyticum from amniotic fluid at 16–20 weeks of gestation: potential Effect on outcome of pregnancy, Sexually Transmitted Diseases 10:294.PubMedGoogle Scholar
  63. Castelazo-Ayala, L., and Karchmer, K. S., 1968, Electrophoresis of proteins in normal and pathological pregnancies; correlation with maternal and fetal flood, J. Int. Fed. Gynaecol. Obstet. 6:67.Google Scholar
  64. Cavalieri, R. L., and Woodling, S., 1984, Purification of lamellar bodies from human amniotic fluid, Am. J. Obstet. Gynecol. 150:409.PubMedGoogle Scholar
  65. Cederqvist, L. L., Queenan, J. T., Gadow, E. C., et al., 1972, The origin of gamma G globulins in human amniotic fluid, Am. J. Obstet. Gynecol. 113:838.PubMedGoogle Scholar
  66. Cederqvist, L. L., Zervoudakis, I. A., Ewool, L., et al., 1977, Prenatal diagnosis of congenital rubella, Br. Med. J. 297:615.CrossRefGoogle Scholar
  67. Cederqvist, L. L., Ewool, L., Bonsnes, R. W., et al., 1978, Detectability and pattern of immunoglobulins in normal amniotic fluid throughout gestation, Am. J. Obstet. Gynecol. 130:220.PubMedGoogle Scholar
  68. Chamberlain, P., 1985, Amniotic fluid volume: ultrasound assessment and clinical significance, Semin. Perinatol. 9:163.PubMedGoogle Scholar
  69. Charles, D., and Edwards, W. R., 1981, Infectious complications of cervical cerclage, Am. J. Obstet. Gynecol. 141:1065.PubMedGoogle Scholar
  70. Charles, D., Jacoby, H. E., and Burgess, F., 1965, Amniotic fluid volumes in the second half of pregnancy, Am. J. Obstet. Gynecol. 93:1042.PubMedGoogle Scholar
  71. Chen, A. B., Mosesson, M. W., and Solish, G. I., 1976, Identification of the cold-insoluble globulin of plasma in amniotic fluid, Am. J. Obstet. Gynecol. 125:958.PubMedGoogle Scholar
  72. Cherry, S. H., Filler, M., and Harvey, H., 1973, Lysozyme content of amniotic fluid, Am. J. Obstet. Gynecol. 116:639.PubMedGoogle Scholar
  73. Chez, R. A., Henkin, R. I., and Fox, R., 1978, Amniotic fluid copper and zinc concentrations in human pregnancy, Obstet. Gynecol. 52:125.PubMedGoogle Scholar
  74. Chochinov, R. H., Mariz, I. K., Hajek, A. S., et al., 1977, Characterization of a protein in mid-term human amniotic fluid which reacts in the somatomedin-C radioreceptor assay, J. Clin. Endocrinol. Metab. 44:902.PubMedCrossRefGoogle Scholar
  75. Claas, A. H. W., Van Diggelen, O. P., Hauri, H. P., et al., 1985, Characteristics of maltase activity in amniotic fluid, Clin. Chim. Acta 145:275.CrossRefGoogle Scholar
  76. Clements, J. A., Reyes, F. I., Winter, J. S. D., et al., 1976, Studies on human sexual development. III. Fetal pituitary and serum, and amniotic fluid concentrations of LH, CG, and FSH, J. Clin. Endocrinol. Metab. 42:9.PubMedCrossRefGoogle Scholar
  77. Clewell, W. H., Stys, S. J., and Battaglia, F. C., 1984, Fetal pathophysiology, Prenat. Diagn. 7:181.Google Scholar
  78. Cockburn, F., Giles, M., Robins, S. P., et al., 1973, Free amino acid composition of human amniotic fluid at term, J. Obstet. Gynaecol. Br. Commonw. 80:10.PubMedCrossRefGoogle Scholar
  79. Condorelli, S., Cosmi, E. V., and Scarpelli, E. M., 1974, Extrapulmonary source of amniotic fluid phospholipids, Am. J. Obstet. Gynecol. 118:842.Google Scholar
  80. Cooper, E., Anderson, A., Bennett, A. H., et al., 1982, Radioimmunoassay of thyroxine and 3,3′,5′-triiodothyronine (reverse T3) in human amniotic fluid, Clin. Chim. Acta 118:57.PubMedCrossRefGoogle Scholar
  81. Couillin, P., Nicolas, H., Boué, J., et al., 1979, HLA typing of amniotic fluid cells applied to prenatal diagnosis of congenital adrenal hyperplasia, Lancet 1:1076.PubMedCrossRefGoogle Scholar
  82. Cowett, R. M., Unsworth, E. J., Hakanson, D. O., et al., 1975, Foam-stability test on gastric aspirate and the diagnosis of respiratory-distress syndrome, N. Engl. J. Med. 293:413.PubMedCrossRefGoogle Scholar
  83. Cox, L. W., and Chalmers, T. A., 1953, The transfer of sodium to the amniotic fluid in normal and abnormal cases, determined by Na24 tracer methods, J. Obstet. Gynaecol. Br. Commonw. 60:222.CrossRefGoogle Scholar
  84. Curl, C. W., 1971, Immunoglobulin levels in amniotic fluid, Am. J. Obstet. Gynecol. 109:408.PubMedGoogle Scholar
  85. Dahlqvist, A., and Lindberg, T., 1966, Development of the intestinal disaccharidase and alkaline phosphatase activities in the human fetus, Clin. Sci. 30:517.PubMedGoogle Scholar
  86. Dallaire, L., 1975, La brebis: Un modèle animal pour les recherches sur le diagnostic prénatal des maladies génétiques humaines, in: Informations Vétérinaires 18:41–42.Google Scholar
  87. Dallaire, L., and Perreault, G., 1974, Hereditary multiple intestinal atresia, Birth Defects Orig. Artie. Ser. X(4):259.Google Scholar
  88. Dallaire, L., Gagnon, M., and Kinch, R. A., 1971, Fetal amino acid metabolism, Clin. Res. XIX: 766.Google Scholar
  89. Dallaire, L., Potier, M., Melançon, S. B., et al., 1974, Fetomaternal amino acid metabolism, J. Obstet. Gynaecol. Br. Common. 81:761.CrossRefGoogle Scholar
  90. Dancis, J., Lind, J., and Vara, P., 1960, Transfer of proteins across the human placenta, in: The Placenta and Fetal Membranes (C.A. Villee, ed.), 185, Williams and Wilkins, New York.Google Scholar
  91. Dancis, J., Lind, J., Oratz, M., et al., 1961, Placental transfer of proteins in human gestation, Am. J. Obstet. Gynecol. 82:167.PubMedGoogle Scholar
  92. Das, S. K., Foster, H. W., Adhikary, P. K., et al., 1975, Gestational variation of fatty acid composition of human amniotic fluid lipids, Obstet. Gynecol. 45:425.PubMedGoogle Scholar
  93. Dattatreyamurty, B., Sheth, A. R., Purandare, T. V., et al., 1979, Gonadotropins during second trimester of pregnancy 1. LH and hCG levels in maternal serum and amniotic fluid and their relationship to the sex of the foetus, Acta Endocrinol. 91:692.PubMedGoogle Scholar
  94. Davidson, G. P., Cutz, E., Hamilton, J. R., et al., 1978, Familial enteropathy: A syndrome of protracted diarrhea from birth, failure to thrive, and hypoplastic villi, Gastroenterology 75:783.PubMedGoogle Scholar
  95. Davis, L. E., Tweed, G. V., Chin, T. D. Y., et al., 1971, Intrauterine diagnosis of cytomegalovirus infection: Viral recovery from amniocentesis fluid, Am. J. Obstet. Gynecol. 109:1217.PubMedGoogle Scholar
  96. Davis, L. E., McLaren, L. C., Stewart, J. A., et al., 1983, Immunological and microbiological studies of midtrimester amniotic fluid, Gynecol. Obstet. Invest. 16:261.PubMedCrossRefGoogle Scholar
  97. Dawood, M. Y., 1977, Hormones in amniotic fluid, Am. J. Obstet. Gynecol. 128:576.PubMedGoogle Scholar
  98. De Castro, A. F., Usategui-Gomez, M., and Spellacy, W. N., 1973, Amniotic fluid amylase, Am. J. Obstet. Gynecol. 116:931.Google Scholar
  99. Deh, M. E., Klouda, P. T., Levine, M., et al., 1982, Detection, isolation and characterization of cell free HLA A and B antigens from human amniotic fluid, Tissue Antigens 20:260.PubMedCrossRefGoogle Scholar
  100. Delecour, M., Monnier, J. C., and Codaccioni, X., 1970, Connaissances actuelles sur la physiologie et la biochimie du liquide amniotique, Gynecol. Obstet. 69:511.Google Scholar
  101. Deleze, G., Sidiropoulos, D., and Paumgartner, G., 1977, Determination of bile acid concentration in human amniotic fluid for the prenatal diagnosis of intestinal obstruction, Pediatrics 59:647.PubMedGoogle Scholar
  102. Deleze, G., Paumgartner, G., Karlaganis, G., et al., 1978, Bile acid pattern in human amniotic fluid, Eur. J. Clin. Invest. 8:41.PubMedCrossRefGoogle Scholar
  103. Derrington, M. M., and Soothill, J. F., 1961, An immunochemical study of the proteins of amniotic fluid and maternal and fetal serum, J. Obstet. Gynaecol. Br. Commonw. 68:755.CrossRefGoogle Scholar
  104. Desnick, R. J., Krivit, W., and Sharp, M. L., 1973, In utero diagnosis of Sandhoffs disease, Biochem. Biophys. Res. Commun. 51:20.PubMedCrossRefGoogle Scholar
  105. Dewhurst, C. J., Harvey, D. R., Dunham, A. M., et al., 1973, Prediction of respiratory-distress syndrome by estimation of surfactant in the amniotic fluid, Lancet 1:1475.PubMedCrossRefGoogle Scholar
  106. Divers, W. A., Jr., Wilkes, M. M., Babaknia, A., et al., 1981, An increase in catecholamines and metabolites in the amniotic fluid compartment from middle to late gestation, Am. J. Obstet. Gynecol. 139:483.PubMedGoogle Scholar
  107. Dodinval, P., and Duvivier, J., 1980, Diagnostic prénatal du sexe par dosage de la testosterone et de la F.S.H. amniotiques, J. Genet. Hum. 28:207.PubMedGoogle Scholar
  108. Donald, I. R., Freeman, R. K., Goebelsmann, U., et al., 1973, Clinical experience with the amniotic fluid lecithin/sphingomyelin ratio. I. Antenatal prediction of pulmonary maturity, Am. J. Obstet. Gynecol. 115:547.PubMedGoogle Scholar
  109. Doran, T. A., Bjerre, S., and Porter, C. J., 1970, Creatinine, uric acid and electrolytes in amniotic fluid, Am. J. Obstet. Gynecol. 106:325.PubMedGoogle Scholar
  110. Doran, T. A., Benzie, R. J., Harkins, J. L., et al., 1974, Amniotic fluid tests for fetal maturity, Am. J. Obstet. Gynecol. 119:829.PubMedGoogle Scholar
  111. Doran, T. A., Malone, R. M., Benzie, R. J., et al., 1976, Amniotic fluid tests for fetal maturity in normal and abnormal pregnancies, Am. J. Obstet. Gynecol. 125:586.PubMedGoogle Scholar
  112. Dorner, G., Stahl, F., Rohde, W., et al., 1977, Sex-specific testosterone and FSH concentrations in amniotic fluids of mid-pregnancy, Endokrinologie 70:86.PubMedGoogle Scholar
  113. Droegemueller, W., Jackson, C., Makowski, E. L., et al., 1969, Amniotic fluid examination as an aid in the assessment of gestational age, Am. J. Obstet. Gynecol. 104:424.PubMedGoogle Scholar
  114. Ducharme, M., 1983, Inhibition de Reactions HLA-Dependantes par Concentré de Liquide Amniotique, Rapport de stagiaire, Etudes Supérieures, Faculté de Médecine, Université de Montréal, Montréal, Québec, Canada.Google Scholar
  115. Duncan, D. M., Logan, R. W., Ferguson-Smith, M. A., et al., 1973, The measurement of acid mucopolysaccharides in amniotic fluid and urine, Clin. Chim. Acta 45:73.PubMedCrossRefGoogle Scholar
  116. Elliott, P. J., and Inman, W. H. W., 1961, Volume of liquor amnii in normal and abnormal pregnancy, Lancet 2:835PubMedCrossRefGoogle Scholar
  117. Emelyanova, A. I., Mikheeva, G. A., and Ermakova, G. G., 1982, Amniotic fluid immunoglobulins at different dates of pregnancy (in Russian), Akusherstvo Ginekol. 7:19.Google Scholar
  118. Emery, A. E. H., Burt, D., Nelson, M. M., et al., 1970, Antenatal diagnosis and aminoacid composition of amniotic fluid, Lancet 1:1307.CrossRefGoogle Scholar
  119. Emery, A. E. H., Eccleston, D., Scrimgeour, J. B., et al., 1972, Amniotic fluid composition in malformations of the central nervous system, J. Obstet. Gynaecol. Br. Commonw. 79:154.PubMedCrossRefGoogle Scholar
  120. Emery, A. E. H., Burt, D., and Scrimgeour, J. B., 1973, Aminoacid composition of amniotic fluid in central nervous system malformations, Lancet 1:970.PubMedCrossRefGoogle Scholar
  121. Emery, A. E. H., Brock, D. J. H., Burt, D., et al., 1974, Amniotic fluid composition in malformations of the fetal central nervous system, J. Obstet. Gynaecol. Br. Commonw. 81:512.PubMedCrossRefGoogle Scholar
  122. Enlander, D., 1972, Amniotic fluid indicators of fetal maturity, Obstet. Gynecol. 40:605.PubMedGoogle Scholar
  123. Evaldson, G., and Nord, C. E., 1981, Amniotic fluid activity against Bacteroides fragilis and group B streptococci, Med. Microbiol. Immunol. 170:11.PubMedCrossRefGoogle Scholar
  124. Evans, H. E., Glass, L., and Mandl, I., 1975, Alphaj-Antitrypsin concentration in amniotic fluid, Biol. Neonate 27:232.PubMedCrossRefGoogle Scholar
  125. Fainaru, M., Deckelbaum, R., and Golbus, M. S., 1981, Apolipoproteins in human fetal blood and amniotic fluid in midtrimester pregnancy, Prenat. Diagn. 1:125.PubMedCrossRefGoogle Scholar
  126. Fencl, M. D., and Tulchinsky, D., 1975, Total Cortisol in amniotic fluid and fetal lung maturation, N. Engl. J. Med. 292:133.PubMedCrossRefGoogle Scholar
  127. Fencl, M., Alonso, C., and Alba, M., 1972, Estriol values in amniotic fluid in the course of normal pregnancy, Am. J. Obstet. Gynecol. 113:367.Google Scholar
  128. Fex, G., Holmberg, N.-G., and Löfstrand, T., 1975, Phospholipids and creatinine in amniotic fluid in relation to gestational age. I. Normal pregnancy, Acta Obstet. Gynecol. Scand. 54:425.PubMedCrossRefGoogle Scholar
  129. Firgaira, F. A., Cotton, R. G. H., Danks, D. M., et al., 1983, Prenatal determination of dihydropteridine reductase in a normal fetus at risk for malignant hyperphenylalaninemia, Prenatal Diagnosis 3:7.PubMedCrossRefGoogle Scholar
  130. Firshein, S. I., Hoyer, L. W., Lazarchick, J., et al., 1979, Prenatal diagnosis of classic hemophilia, N. Engl. J. Med. 300:937.PubMedCrossRefGoogle Scholar
  131. Fischbacher, P. H., and Quinlivan, W. L. C., 1970, Qualitative and quantitative analysis of the proteins in human amniotic fluid, Am. J. Obstet. Gynecol. 108:1050.Google Scholar
  132. Florman, A., and Teubner, D., 1969, Enhancement of bacterial growth in amniotic fluid by meconium, J. Pediatr. 74:111.PubMedCrossRefGoogle Scholar
  133. Flossner, O., and Kirstein, F., 1926, Biochemische Untersuchungen über das menschliche Fruchtwasser, Z. Biol. (Munich) 84:510.Google Scholar
  134. Fluharty, A. L., Scott, M. L., Porter, M. T., et al., 1973, Acid alpha-glucosidase in amniotic fluid, Biochem. Med. 7:39.PubMedCrossRefGoogle Scholar
  135. Ford, L. C., Delanse, R. J., and Lebherz, T. B., 1977, Identification of a bactericidal factor (B-lysin) in amniotic fluid at 14 and 40 weeks’ gestation, Am. J. Obstet. Gynecol. 127:788.PubMedGoogle Scholar
  136. Franks, R. C., and Hayashi, R. H., 1979, Maternal and fetal renin activity and renin and big renin concentrations in second-trimester pregnancy, Am. J. Obstet. Gynecol. 134:20.PubMedGoogle Scholar
  137. Frantz, T., Lindback, T., Skjaeraasen, J., et al., 1975, Phospholipids in amniotic fluid. II. Lecithin fatty acid patterns related to gestation, maternal disease and fetal outcome, Acta Obstet. Gynecol. Scand. 54:33.PubMedCrossRefGoogle Scholar
  138. Freda, J. V., 1958, A-B-0 (H) blood group substances in the human maternal-fetal barrier and amniotic fluid, Am. J. Obstet. Gynecol. 76:407.PubMedGoogle Scholar
  139. Freeman, R. K., Bateman, B. G., Goebelsmann, U., et al., 1974, Clinical experience with the amniotic fluid lecithin/sphingomyelin ratio. II. The L/S ratio in “stressed pregnancies,” Am. J. Obstet. Gynecol. 119:239.PubMedGoogle Scholar
  140. Freeman, R., Lev-Gur, M., Koslowe, R., et al., 1984, Maternal plasma and amniotic fluid levels of estradiol, estrone, progesterone and prolactin in early pregnancy, Obstet. Gynecol. 63:507.PubMedGoogle Scholar
  141. Friedland, J., Perle, G., Saifer, A., et al., 1971, Screening for Tay-Sachs disease in utero using amniotic fluid, Proc. Soc. Exp. Biol. Med. 136:1297.PubMedGoogle Scholar
  142. Friedrich, E., Habedank, M., Cooreman, G., et al., 1981, Diagnostik der fötalen schilddrusenfunktion durch amniocentese, Z. Geburtshilfe Perinatol. 185:96.PubMedGoogle Scholar
  143. Frosolono, M. F., and Roux, J. F., 1978, Surface-active material in human amniotic fluid, Am. J. Obstet. Gynecol. 130:562.PubMedGoogle Scholar
  144. Fuchs, F., 1966, Volume of amniotic fluid at various stages of pregnancy, Clin. Obstet. Gynecol. 9:449.PubMedCrossRefGoogle Scholar
  145. Fujikura, T., and Klionsky, B., 1975, The significance of meconium staining, Am. J. Obstet. Gynecol. 121:45.PubMedGoogle Scholar
  146. Gadow, E. C., Floriani, F. A., and Florin, A., 1974, IgG levels in amniotic fluid, Am. J. Obstet. Gynecol. 119:849.PubMedGoogle Scholar
  147. Gagné, R., Lescault, A., Grenier, A., et al., 1982, Prenatal diagnosis of hereditary tyrosinaemia: Measurement of succinylacetone in amniotic fluid, Prenat. Diagn. 2:149.CrossRefGoogle Scholar
  148. Galask, R. P., and Snyder, I. R., 1968, Bacterial inhibition by amniotic fluid, Am. J. Obstet. Gynecol. 102:949.PubMedGoogle Scholar
  149. Galask, R. P., and Snyder, I. R., 1970, Antimicrobial factors in amniotic fluid, Am. J. Obstet. Gynecol. 106:59.PubMedGoogle Scholar
  150. Gautray, J. P., Jolivet, A., Vielh, J. P., et al., 1977, Presence of immunoassayable beta-endorphin in human amniotic fluid: Elevation in cases of fetal distress, Am. J. Obstet. Gynecol. 129:211.PubMedGoogle Scholar
  151. Geirsson, R. T., Patel, N. B., and Christie, A. D., 1984, In-vivo accuracy of ultrasound measurements of intrauterine volume in pregnancy, Br. J. Obstet. Gynaecol. 91:37.PubMedCrossRefGoogle Scholar
  152. Genazzoni, A. R., Petraglia, F., Parrini, D., et al., 1984, Lack of correlation between amniotic fluid and maternal plasma contents of beta-endorphin, beta-lipotropin, and adrenocorticotropic hormone in normal and pathologic pregnancies, Am. J. Obstet. Gynecol. 148:198.Google Scholar
  153. Geyer, H., 1970, Zie Herkunft der Fruchtwasser-enzyme, Z. Klin, Chem. Klin. Biochem. 8:145.Google Scholar
  154. Geyer, H., and Schneider, I., 1970, Enzyme in Fruchtwasser, Z. Klin. Chem. Klin. Biochem. 8:141.PubMedGoogle Scholar
  155. Giamarellou, H., Gazis, J., Petrikkos, G., et al., 1983, A study of cefoxitin, moxalactam, and ceftazidime kinetics in pregnancy, Am. J. Obstet. Gynecol. 147:914.PubMedGoogle Scholar
  156. Gibbons, J. M., Huntley, T. E., and Corral, A. G., 1974, Effect of maternal blood contamination on amniotic fluid analysis, Obstet. Gynecol. 44:657.PubMedGoogle Scholar
  157. Giblett, E. R., 1969, Genetic Markers in Human Blood, Blackwell, Oxford.Google Scholar
  158. Giles, H. R., Lox, C.D., Heine, W., et al., 1974, Intrauterine fetal sex determination by radioimmunoassay of amniotic fluid testosterone, Gynecol. Invest. 5:317.PubMedCrossRefGoogle Scholar
  159. Gillibrand, P. N., 1969, Changes in amniotic fluid volume with advancing pregnancy, J. Obstet. Gynaecol. Br. Commonw. 76:527.PubMedCrossRefGoogle Scholar
  160. Gitlin, D., Kumante, J., Urrusti, J., et al., 1964, The selectivity of the human placenta in the transfer of plasma proteins from mother to fetus, J. Clin. Invest. 43:1938.PubMedCrossRefGoogle Scholar
  161. Gitlin, D., Kumate, J., Morales, C., et al., 1972, The turnover of amniotic fluid protein in the human conceptus, Am. J. Obstet. Gynecol. 113:632.PubMedGoogle Scholar
  162. Gleicher, N., 1980, Immunological influence of amniotic fluid, Lancet 1:541.PubMedCrossRefGoogle Scholar
  163. Gluck, L., 1972, Surfactant: 1972, Pediatr. Clin. N. Am. 19:325.Google Scholar
  164. Gluck, L., and Kulovich, M. V., 1973, Lecithin/sphingomyelin ratios in amniotic fluid in normal and abnormal pregnancy, Am. J. Obstet. Gynecol. 115:539.PubMedGoogle Scholar
  165. Gluck, L., Landowne, R. A., and Kulovich, M. V., 1970, Biochemical development of surface activity in mammalian lung. 3. Structural changes in lung lecithin during development of the rabbit fetus and newborn, Pediatr. Res. 4:352.PubMedCrossRefGoogle Scholar
  166. Gluck, L., Kulovich, M. V., Borer, R. C., et al., 1971, Diagnosis of the respiratory distress syndrome by amniocentesis, Am. J. Obstet. Gynecol. 109:440.PubMedGoogle Scholar
  167. Goebelsmann, U., Abboud, T. K., Hoffman, D. L, et al., 1984, Beta-endorphin in pregnancy, Eur. J. Obstet. Reprod. Biol. 17:77.CrossRefGoogle Scholar
  168. Granat, M., Sharf, M., and Weissman, B. A., 1980, Humoral endorphin in human body fluids during pregnancy, Gynecol. Obstet. Invest. 11:214.PubMedCrossRefGoogle Scholar
  169. Gray, M. J., Neslen, E. D., and Plentl, A. A., 1956, Estimation of water transfer from amniotic fluid to fetus, Proc. Soc. Exp. Biol. Med. 92:463.PubMedGoogle Scholar
  170. Green, G. H., 1955, Fetal renal hypoplasia and the origin of amniotic fluid, J. Obstet. Gynaecol. Br. Commonw. 62:592.CrossRefGoogle Scholar
  171. Grossman, I. W., and Sacktor, B., 1968, Histochemical localization of renal trehalase: Demonstration of a tubular site, Science 161:571.PubMedCrossRefGoogle Scholar
  172. Gusdon, J., 1962, A bactericidin for Bacillus subtilis in pregnancy, J. Immunol. 88:494.PubMedGoogle Scholar
  173. Hagenfeldt, L., and Hagenfeldt, K., 1976, Individual free fatty acids in amniotic fluid and in plasma of pregnant women, Br. J. Obstet. Gynecol. 83:383.CrossRefGoogle Scholar
  174. Hahn, P., Skala, J. P., Seccombe, D. W., et al., 1977, Carnitine content of blood and amniotic fluid, Pediatr. Res. 11:878.PubMedCrossRefGoogle Scholar
  175. Hall, P. W., III, and Roux, J. F., 1974, Amniotic fluid beta-2 microglobulin concentration—An index of gestational age, Am. J. Obstet. Gynecol. 120:56.PubMedGoogle Scholar
  176. Hall, G. S., Carr, M. J., Cummins, E., et al., 1983, Aluminium, barium, silicon, and strontium in amniotic fluid by emission spectrometry, Clin. Chem. 29:1318.PubMedGoogle Scholar
  177. Hamilton, W. J., Boyd, J. D., and Mossman, H. W., 1964, Human Embryology, Heffer, Cambridge.Google Scholar
  178. Hankins, G. D. V., Rowe, J., Quirk, J. G., et al., 1984, Significance of brown and/or green amniotic fluid at the time of second trimester genetic amniocentesis, Obstet. Gynecol. 64:353.PubMedGoogle Scholar
  179. Harper, P., Bias, W. B., Hutchinson, J. R., et al., 1971, ABH secretor status of the fetus: A genetic marker identifiable by amniocentesis, J. Med. Genet. 8:438.PubMedCrossRefGoogle Scholar
  180. Harwick, H. J., Iuppa, J. B., and Fekety, F. R., 1969, Microorganisms and amniotic fluid, Obstet. Gynecol. 33:256.PubMedGoogle Scholar
  181. Harzer, K., 1974, Erste erfahrungen bei der pränatalen diagnose der Tay-Sachsschen Erkrankung durch isoelektrische fokussierung der hexosaminidase A aus amnion-flussigkeit, Klin. Wochenschr. 52:145.PubMedCrossRefGoogle Scholar
  182. Heikinheimo, M., Seppala, M., and Brock, D. J. H., 1980, Pregnancy specific beta1-glycoprotein and human chorionic gonadotrophin levels in amniotic fluid and maternal serum in the first half of pregnancy, Oncodev. Biol. Med. 1:71.PubMedGoogle Scholar
  183. Heikinheimo, M., Aula, P., Rapola, J., et al., 1982, Amniotic fluid pregnancy-specific beta1-glycoprotein (SP1) in Meckel’s syndrome: A new test for prenatal diagnosis? Prenat. Diagn. 2:103.PubMedCrossRefGoogle Scholar
  184. Heikinheimo, M., Jalanko, H., Leisti, J., et al., 1984, Amniotic fluid pregnancy-specific beta1-glycoprotein (SP1) in fetal developmental disorders, Prenat. Diagn. 4:147.PubMedCrossRefGoogle Scholar
  185. Heikkinen, J., Maentausta, O., Tuimala, R., et al., 1980, Amniotic fluid bile acids in normal and pathologic pregnancy, Obstet. Gynecol. 56:60.PubMedGoogle Scholar
  186. Hellstrom, W. J. G., Barry, A., Kogan, R., et al., 1984, Natural history of prenatal hydronephrosis with normal amounts of amniotic fluid, Ped. Art. 132:947.Google Scholar
  187. Helmy, F. M., and Hack, M. H., 1962, Comparison of the lipids in maternal and cord blood and of human amniotic fluid, Proc. Soc. Exp. Biol. Med. 110:91.PubMedGoogle Scholar
  188. Henneman, C. E., Anderson, G. V., Tejavej, A., et al., 1970, Fetal maturation and amniotic fluid, Am. J. Obstet. Gynecol. 108:302.PubMedGoogle Scholar
  189. Heron, H. J., 1966, The electrophoresis of proteins of amniotic fluid, J. Obstet. Gynaecol. Br. Commonw. 73:91.PubMedCrossRefGoogle Scholar
  190. Hibbard, B. M., 1972, Polyhydramnios and oligohydramnios, Clin. Obstet. Gynecol. 5:1044.Google Scholar
  191. Hodari, A. A., Mariona, F. G., Houlihan, R. T., et al., 1973, Creatinine transport in the maternal-fetal complex, Obstet. Gynecol. 41:47.PubMedGoogle Scholar
  192. Hook, G. E. R., Gilmore, L. B., Tombopoulos, E. G., et al., 1978, Fetal lung lamellar bodies in human amniotic fluid, Am. Rev. Respir. Dis. 117:541.PubMedGoogle Scholar
  193. Hüfner, M., Grussendorf, M., Lorenz, U., et al., 1977, 3,3′,5′-Triiodothyronine (reverse T3) in amniotic fluid and cord serum, Eur. J. Pediatr. 125:213.PubMedCrossRefGoogle Scholar
  194. Huijing, F., Warren, R. J., and McLeod, A. G. W., 1973, Elevated activity of lysosomal enzymes in amniotic fluid of a fetus with mucolipidosis II (I-cell disease), Clin. Chim. Acta 44:453.PubMedCrossRefGoogle Scholar
  195. Hutchinson, D. L., Hunter, C. B., Neslen, E. D., et al., 1955, Exchange of water and electrolytes in the mechanism of amniotic fluid formation and the relationship of hydramnios, Surg. Gynecol. Obstet. 100:391.PubMedGoogle Scholar
  196. Hutchinson, D. L., Gray, M. J., Plentl, A. A., et al., 1959, The role of the fetus in the water exchange of the amniotic fluid of normal and hydroamniotic patients, J. Clin. Invest. 38:971.PubMedCrossRefGoogle Scholar
  197. Immken, L., Lee, M., Stewart, R., et al., 1982, Significance of meconium stained fluid in midtrimester amniocentesis, Birth Defects Orig. Artic. Ser. XVIII: 187.Google Scholar
  198. Ip, M. P. C., Draisey, T. F., Thibert, R. J., et al., 1977, Fetal lung maturity, as assessed by gas-liquid chromatographic determination of phospholipid palmitic acid in amniotic fluid, Clin. Chem. 23:35.PubMedGoogle Scholar
  199. Izaka, K., Shirakawa, H., Yamada, M., et al., 1971, Method for isolation of human placental lysozyme, Anal. Biochem. 42:299.PubMedCrossRefGoogle Scholar
  200. Jalanko, H., 1983, Developmental changes in gamma-glutamyl transpeptidase in human amniotic fluid, Oncodev. Biol. Med. 4:252.Google Scholar
  201. Jalanko, H., and Aula, P., 1982, Decrease in gamma-glutamyl transpeptidase activity in early amniotic fluid in fetal trisomy 18 syndrome, Br. Med. J. 284:1593.CrossRefGoogle Scholar
  202. Jalanko, H., Rapola, J., and Lehtonen, E., 1985, Particulate fraction in amniotic fluid at second trimester, J. Clin. Pathol. 38:1065.PubMedCrossRefGoogle Scholar
  203. Jalanko, H., Heikinheimo, M., Ryynanen, M., et al., 1983, Alkaline phosphatase activity in amniotic fluid in pregnancies with fetal disorders, Prenat. Diagn. 3:303.PubMedCrossRefGoogle Scholar
  204. Jarmas, A. L., Weaver, D. D., Padilla, L. M., et al., 1983, Hirschsprung disease: Etiologic implications of unsuccessful prenatal diagnosis, Am. J. Med. Genet. 16:163.PubMedCrossRefGoogle Scholar
  205. Jeffcoate, T. N. A., and Scott, J. S., 1959, Polyhydramnios and oligohydramnios, Can. Med. Assoc. J. 80:77.PubMedGoogle Scholar
  206. Jezuita, J., Wisniewski, L., Bogoniowska, Z., et al., 1983, Endokrynologia prenatalna, Ginekol. Pol. 54:11.Google Scholar
  207. Johnell, H. E., and Nilsson, B. A., 1971, Oxygen tension, acid-base status and electrolytes in human amniotic fluid, Acta Obstet. Gynecol. Scand. 50:183.PubMedCrossRefGoogle Scholar
  208. Johnson, A. M., Umansky, I., Alper, A. A., et al., 1974, Amniotic fluid proteins: Maternal and fetal contributions, J. Pediatr. 84:588.PubMedCrossRefGoogle Scholar
  209. Jonasson, L.-E., Ervin, P.-E., and Wibell, L., 1974, Content of beta2-microglobulin and albumin in amniotic fluid, Acta Obstet. Gynecol. Scand. 53:63.CrossRefGoogle Scholar
  210. Jones, M. I., Spragg, S. P., and Webb, T., 1981, Detection of proteins in human amniotic fluid using two-dimensional gel electrophoresis, Biol. Neonate 39:171.PubMedCrossRefGoogle Scholar
  211. Jorgensen, O. S., and Norgaard-Pedersen, B., 1981, The synaptic membrane D2-protein in amniotic fluid from pregnancies with fetal neural tube defects, Prenat. Diagn. 1:3.PubMedCrossRefGoogle Scholar
  212. Judd, H. L., Robinson, J. D., Young, P. E., et al., 1976, Amniotic fluid testosterone levels in midpregnan-cy, Obstet. Gynecol. 48:690.PubMedGoogle Scholar
  213. Kamoun, P., Parvy, D. P., Dinh, P., et al., 1983, Citrulline in amniotic fluid and the prenatal diagnosis of citrullinemia, Prenat. Diagn. 3:53.PubMedCrossRefGoogle Scholar
  214. Kaufman, S., 1966, Protein-bound iodine (PBI) in human amniotic fluid, J. Pediatr. 68:990.PubMedCrossRefGoogle Scholar
  215. Kenny, A. J., and Maroux, S., 1982, Topology of microvillar membrane hydrolases of kidney and intestine, Physiol. Rev. 62:91.PubMedGoogle Scholar
  216. Keppen, L. D., Pysher, T., and Rennert, O. M., 1985, Zinc deficiency acts as a co-teratogen with alcohol in fetal alcohol syndrome, Pediatr. Res. 19:944.PubMedCrossRefGoogle Scholar
  217. Kerenyi, T., and Sarkozi, L., 1974, Diagnosis of fetal death in utero by elevated amniotic fluid CPK levels, Obstet. Gynecol. 44:215.Google Scholar
  218. Kitzmiller, J. L., Highby, S., and Lucas, W. E., 1973, Retarded growth of E. coli in amniotic fluid, Obstet. Gynecol. 41:38.PubMedGoogle Scholar
  219. Kleijer, W. J., Blom, W., Huijmans, J. G. M., et al., 1984, Prenatal diagnosis of citrullinemia: Elevated levels of citrulline in the amniotic fluid in the three affected pregnancies, Prenat. Diagn. 4:113.PubMedCrossRefGoogle Scholar
  220. Kleist, S. V., Buff, D., and Burtin, P., 1968, Relation entre les antigènes du liquide amniotique et du serum foetal, Clin. Chim. Acta 20:89.CrossRefGoogle Scholar
  221. Klopper, A., 1970, Oestriol in amniotic fluid, Proc. R. Soc. Med. 63:1090.PubMedGoogle Scholar
  222. Kunzig, H. J., Meyer, U., Schmitz-Roeckerath, B., et al., 1977, Influence of fetal sex on the concentration of amniotic fluid testosterone: Antenatal sex determination? Arch. Gynakol. 223:75.PubMedCrossRefGoogle Scholar
  223. Kvittingen, E. A., Halvorsen, S., Jellum, E., et al., 1983, Deficient fumarylacetoacetate fumarylhydrolase activity in lymphocytes and fibroblasts from patients with hereditary tyrosinemia, Pediatr. Res. 14:541.CrossRefGoogle Scholar
  224. Lacourt, G. C., Arendt, J., Cox, J., et al., 1977, Microcephalic dwarfism with associated low amniotic fluid 5-hydroxyindole-3-acetic acid (5HIAA): Report of a case of Cornelia de Lange syndrome, Helv. Paediatr. Acta 32:149.PubMedGoogle Scholar
  225. Lambotte, R., 1966, Isolement et propriétés d’un alpha1-globuline spécifique du liquide amniotique humain, Arch. Int. Physiol. Biochim. 74:284.PubMedCrossRefGoogle Scholar
  226. Lambotte, R., and Gosselin-Ray, C., 1967, Analyse électrophorétique de la teneur en polysaccharides de l’alpha1-globuline spécifique du liquide amniotique humain, Arch. Int. Physiol. Biochim. 75:109.PubMedCrossRefGoogle Scholar
  227. Lambotte, R., and Salmon, J., 1962, Etude immunoélectrophorétique du liquide amniotique humain, C. R. Soc. Biol. 156:530.Google Scholar
  228. Lambotte, R., and Uhlenbruck, G., 1966, Amniomucoids—A new class of hexosamine-rich glycoproteins, Nature 212:290.PubMedCrossRefGoogle Scholar
  229. Landing, B. H., 1950, Amnio nodosum; a lesion of the placenta apparently associated with deficient secretion of fetal urine, Am. J. Obstet. Gynecol. 60:1339.PubMedGoogle Scholar
  230. Lapan, B., and Friedman, M. M., 1962, Enzymes in the amniotic fluid and maternal serum, Am. J. Obstet. Gynecol. 83:1337.PubMedGoogle Scholar
  231. Lappin, T. R. J., 1971, The measurement of non-esterified fatty acids in icteric body fluids, Clin. Chim. Acta 33:153.PubMedCrossRefGoogle Scholar
  232. Larsen, B., Galask, R. P., and Snyder, I. S., 1974a, Muramidase and peroxidase activity of human amniotic fluid, Obstet. Gynecol. 44:219.PubMedGoogle Scholar
  233. Larsen, B., Snyder, I. S., and Galask, R. P., 1974b, Bacterial growth inhibition by amniotic fluid. I. In vitro evidence for bacterial growth-inhibiting activity. Am. J. Obstet. Gynecol. 119:492.PubMedGoogle Scholar
  234. Lebon, P., Girard, S., Thépot, F., et al., 1981, Embryologie générale: Présence constante d’interféron de type d dans les liquides amniotiques humains, C. R. Acad. Sci. Paris 293:69.Google Scholar
  235. Ledge, M., 1981, Dark brown amniotic fluid—Identification of contributing pigments, Br. J. Obstet. Gynaecol. 88:632.CrossRefGoogle Scholar
  236. Lee, T. Y., and Schafer, I. A., 1974, Glycosaminoglycan composition of human amniotic fluid, Biochim. Biophys. Acta 354:264.PubMedCrossRefGoogle Scholar
  237. Lewis, J. F., Johnson, P., and Miller, P., 1976, Evaluation of amniotic fluid for aerobic and anaerobic bacteria, Am. J. Clin. Pathol. 65:58.PubMedGoogle Scholar
  238. Lind, T., and Hytten, F. E., 1970, Relation of amniotic fluid volume to fetal weight in the first half of pregnancy, Lancet 1:1147.PubMedCrossRefGoogle Scholar
  239. Lind, T., Parkin, F. M., and Cheyne, G. A., 1969, Biochemical and cytological changes in liquor amnii with advancing gestation, J. Obstet. Gynaecol. Br. Commonw. 76:673.PubMedCrossRefGoogle Scholar
  240. Lind, T., Kendall, A., and Hytten, F. E., 1972, The role of the fetus in the formation of amniotic fluid, J. Obstet. Gynaecol. Br. Commonw. 79:289.PubMedCrossRefGoogle Scholar
  241. Lindback, T., and Frantz, T., 1975, Effect of centrifugation on amniotic fluid phospholipid recovery, Acta Obstet. Gynecol. Scand. 54:101.PubMedCrossRefGoogle Scholar
  242. Lindblad, B., Lindstedt, S., and Steen, G., 1977, On the enzymic defects in hereditary tyrosinemia, Proc. Natl. Acad. Sci. (USA) 74:4641.CrossRefGoogle Scholar
  243. Lowden, J. A., Cutz, E., Conen, P. E., et al., 1973, Prenatal diagnosis of GM1-gangliosidosis, N. Engl. J. Med. 288:225.PubMedCrossRefGoogle Scholar
  244. Mallikarjuneswara, V. R., 1975, Lecithin-sphingomyelin ratio in amniotic fluid, as assessed by a modified thin-layer chromatographic method in which a commercial pre-coated plate is used. Clin. Chem. 21:260.PubMedGoogle Scholar
  245. Matthews, C. D., and Martin, M. R., 1974, Early detection of meconium-stained liquor during labor: A contribution to fetal care, Am. J. Obstet. Gynecol. 36:808.Google Scholar
  246. Mattison, D. R., 1970, Amniotic fluid osmolality, Obstet. Gynecol. 36:420.PubMedGoogle Scholar
  247. McKay, D. G., Richardson, M. V., and Hertig, A. T., 1958, Studies of the function of early human trophoblast, Am. J. Obstet. Gynecol. 75:699.PubMedGoogle Scholar
  248. Mean, F., Pescia, G., Vajda, D., et al., 1981, Amniotic fluid testosterone in prenatal sex determination, J. Genet. Hum. 29:441.PubMedGoogle Scholar
  249. Melançon, S. B., Gagné, R., Grenier, A., et al., 1983, Deficiency of fumarylacetoacetase in the acute form of hereditary tyrosinemia with reference to prenatal diagnosis, in: Pediatric Liver Disease (M. M. Fisher and C. C. Roy, eds.), p. 223, Plenum Press, New York.Google Scholar
  250. Mennuti, M. T., Wu, C. H., and Mellman, W. J., 1977, Amniotic fluid testosterone and follicle stimulating hormone levels as indicators of fetal sex during mid-pregnancy, Am. J. Med. Genet. 1:211.PubMedCrossRefGoogle Scholar
  251. Mentasti, P., 1959, Il protidogramma del liquido amniotico valutazione con microelettroforesi libra, Minerva Ginecol. 2:541.Google Scholar
  252. Merger, C., Blanc, B., Ruf, H., et al., 1981, The level of testosterone, delta 4-androstenedione, and S-DHA in liquor and fetal sex, J. Gynecol. Obstet. Biol. Reprod. (Paris) 10:567.Google Scholar
  253. Michie, E. A., and Robertson, J. G., 1971, Amniotic and urinary oestriol assays in pregnancies complicated by rhesus immunization, J. Obstet. Gynaecol. Br. Commonw. 78:34.PubMedCrossRefGoogle Scholar
  254. Monaghan, J. M., Horn, D. B., and Brock, D. J. H., 1973, Alpha]-antitrypsin in amniotic fluid, Lancet 2:619.PubMedCrossRefGoogle Scholar
  255. Monie, I. W., 1953, The volume of the amniotic fluid in the early months of pregnancy, Am. J. Obstet. Gynecol. 66:616.PubMedGoogle Scholar
  256. Monif, G. R. G., and Mendenhall, H. W., 1970, Immunoglobulin G levels and the titers of specific antiviral antibodies in amniotic fluid, Am. J. Obstet. Gynecol. 108:651.PubMedGoogle Scholar
  257. Moniz, C., Nicolaides, K. H., Heys, D., et al., 1984, Gamma-glutamyl transferase activity in fetal serum, maternal serum and amniotic fluid during gestation, J. Clin. Pathol. 37:700.PubMedCrossRefGoogle Scholar
  258. Moore, W. M. O., Murphy, P. J., and Davis, J. A., 1971, Creatinine content of amniotic fluid in cases of retarded fetal growth, Am. J. Obstet. Gynecol. 110:908.PubMedGoogle Scholar
  259. Morgan, D. M. L., and Hytten, F. E., 1984, Mid-trimester pregnancy a time of tranquility or activity? Br. J. Obstet. Gynaecol. 91:532.PubMedCrossRefGoogle Scholar
  260. Morgan-Capner, P., Rodeck, C. H., Nicolaides, K. H., 1985, Prenatal detection of rubella-specific IgM in fetal sera, Prenat. Diagn. 5:21.PubMedCrossRefGoogle Scholar
  261. Morin, P. R., 1979, Etude d’un Modèle Expérimental pour le Diagnostic Prénatal de la Fibrose Kystique, Mémoire de Maitrise, Département de Sciences Cliniques, Université de Montréal, Montréal, Québec, Canada.Google Scholar
  262. Morin, P. R., Potier, M., Dallaire, L., et al., 1980, Prenatal detection of intestinal obstruction: Deficient amniotic fluid disaccharidases in affected fetuses, Clin. Genet. 18:217.PubMedCrossRefGoogle Scholar
  263. Morin, P. R., Potier, M., and Dallaire, L., et al., 1981, Prenatal detection of the autosomal recessive type of polycystic kidney disease by trehalase assay in amniotic fluid, Prenat. Diagn. 1:75.PubMedCrossRefGoogle Scholar
  264. Morin, P. R., Potier, M., and Lasalle, R., et al., 1983, Amniotic fluid disaccharidases in the prenatal detection of cystic fibrosis, Lancet 2:621.PubMedCrossRefGoogle Scholar
  265. Morin, P. R., Potier, M., Dallaire, L., et al., 1984, Prenatal detection of the congenital nephrotic syndrome (Finnish type) by trehalase assay in amniotic fluid, Prenat. Diagn. 4:257.PubMedCrossRefGoogle Scholar
  266. Morin, P. R., Melançon, S. B., Dallaire, L., et al., 1986, Prenatal detection of intestinal obstructions, chromosomal syndromes and cystic fibrosis by microvillar enzyme assays (disaccharidases, alkaline phosphatase and glutamyl transferase) in amniotic fluid, Amer. J. Med. Genet, (in press).Google Scholar
  267. Mulivor, R. A., Mennuti, M. T., and Harris, H., 1979, Origin of the alkaline phosphatases in amniotic fluid, Am. J. Obstet. Gynecol. 135:77.PubMedGoogle Scholar
  268. Muller-Eberhard, U., and Bashore, R., 1970, Assessment of Rh disease by ratios of albumin and hemopexin to albumin in amniotic fluid, N. Engl. J. Med. 282:1163.PubMedCrossRefGoogle Scholar
  269. Müller-Tyl, E., Lempert, J., Steinbereithner, K., et al., 1975, Surface properties of the amniotic fluid in normal pregnancy, Am. J. Obstet. Gynecol. 122:295.PubMedGoogle Scholar
  270. Murphy, B. E. P., Patrick, J., and Denton, R. L., 1975, Cortisol in amniotic fluid during human gestation, J. Clin. Endocrinol. Metab. 40:164.PubMedCrossRefGoogle Scholar
  271. Nadler, H. L., and Messina, A. M., 1969, In utero detection of type II glycogenosis (Pompe’s disease), Lancet 2:1277.PubMedCrossRefGoogle Scholar
  272. Nadler, H. L., Bigley, R. H., and Hug, G., 1970, Prenatal detection of Pompe’s disease, Lancet 2:369.CrossRefGoogle Scholar
  273. Nazamani, M., McDonough, P. G., Ellegood, J. O., et al., 1979, Maternal and amniotic fluid steroids throughout human pregnancy, Am. J. Obstet. Gynecol. 134:674.Google Scholar
  274. Nelson, M. M., 1972, Amniotic fluid volumes in early pregnancy, J. Obstet. Gynaecol. Br. Commonw. 79:50.PubMedCrossRefGoogle Scholar
  275. Nelson, M. M., and Emery, A. E. H., 1970, Amniotic fluid cells, prenatal sex prediction and culture, Br. Med. J. 1:523.PubMedCrossRefGoogle Scholar
  276. Newman, R. L., and Tutera, G., 1976, The glucose-insulin ratio in amniotic fluid, Obstet. Gynecol. 47:599.PubMedGoogle Scholar
  277. Nicholls, T., Hähnel, R., Wilkinson, S., et al., 1976, Identification of 2-hydroxybutyric acid in human amniotic fluid, Clin. Chim. Acta 69:127.PubMedCrossRefGoogle Scholar
  278. Nicholls, T. M., Hähnel, R., and Wilkinson, S. P., 1978, Organic acids in amniotic fluid, Clin. Chim. Acta 84:11.PubMedCrossRefGoogle Scholar
  279. Niswander, K. R. 1970, Spectrophotometric analysis of amniotic fluid in early gestation, Am. J. Obstet. Gynecol. 108:1296.PubMedGoogle Scholar
  280. Nusbaum, M. J., and Zettner, A., 1973, The content of Ca, Mg, Cu, Fe, Na, and K in amniotic fluid from eleven to nineteen weeks’ gestation, Am. J. Obstet. Gynecol. 115:219.PubMedGoogle Scholar
  281. O’Brien, J. S., Okada, S., Fillerup, D. L., et al., 1971, Tay-Sachs disease: Prenatal diagnosis, Science 172:61.PubMedCrossRefGoogle Scholar
  282. Ojala, A., 1971, Studies on Bilirubin in Amniotic Fluid with Special Reference to Liver Function Tests, 1st ed., Kirjapaino Osakeyhtio Kaleva, Oulu, Finland.Google Scholar
  283. O’Neill, R. T., Morrow, G., III, Hammel, D., et al., 1971, Diagnostic significance of amniotic fluid amino acids, Obstet. Gynecol. 37:550.PubMedGoogle Scholar
  284. Ostergard, D. R., 1970, The physiology and clinical importance of amniotic fluid: A review, Obstet. Gynecol. Surv. 25:297.PubMedCrossRefGoogle Scholar
  285. Oulton, M., Martin, T. R., and Faulkner, G. T., 1980, Developmental study of lamellar body fraction isolated from human amniotic fluid, Pediatr. Res. 14:722.PubMedCrossRefGoogle Scholar
  286. Pacsa, A. S., and Pejtsik, B., 1977, Impairment of immunity during pregnancy and antiviral effect of amniotic fluid, Lancet 1:330.PubMedCrossRefGoogle Scholar
  287. Pajor, A., Grof, J., Idel, M., et al., 1982, Utero-inhibin: A new substance inhibiting uterine contraction, isolated from amniotic fluid, Acta Phys. Acad. Sci. Hung. 59:325.Google Scholar
  288. Palliez, R., Bisert, G., Savary, J., et al., 1956, Biochimie amniotique, complexes protéiques, acides organiques et cétoniques, Bull. Soc. R. Belge Gynecol. Obstet. 26:446.Google Scholar
  289. Papp, Z., Ember, L, Juhasz, E., et al., 1977, Acid-soluble glycoproteins in amniotic fluid and cystic fibrosis of the foetus, Clin. Genet. 11:431.PubMedCrossRefGoogle Scholar
  290. Parkinson, C. E., and Gal, I., 1974, Vitamin A and seasonal variation, Lancet 1:937.PubMedCrossRefGoogle Scholar
  291. Parkinson, C.E., Tan, J. C., and Gal, I., 1982, Vitamin A concentration in amniotic fluid and maternal serum related to neural-tube defects, Br. J. Obstet. Gynaecol. 89:935.PubMedCrossRefGoogle Scholar
  292. Parmley, T. H., and Seeds, A. E., 1970, Fetal skin permeability to isotopic water (THO) in early pregnancy, Am. J. Obstet. Gynecol. 108:128.PubMedGoogle Scholar
  293. Peltonen, J., Vinikka, L., and Laatikainen, T., 1977, Amniotic fluid Cortisol during gestation and its relation to fetal lung maturation, J. Steroid Biochem. 8:1159.PubMedCrossRefGoogle Scholar
  294. Scott, J. S., 1966, The volume and circulation of the liquor amnii: Clinical observations, Proc. R. Soc. Med. 59:1128.PubMedGoogle Scholar
  295. Scott, J. S., and Bain, A. D., 1958, Amnion nodosum, Proc. R. Soc. Med. 51:512.PubMedGoogle Scholar
  296. Scott, J. S., and Wilson, J. K., 1957, Hydramnios as an early sign of esophageal atresia, Lancet 1:569.CrossRefGoogle Scholar
  297. Seeds, A. E., Jr., 1968, Amniotic fluid and fetal water metabolism, in: Intrauterine Development (A. C. Barnes, ed.), p. 129, Lea and Febiger, Philadelphia.Google Scholar
  298. Seeds, A. E., Jr., 1974, Dynamics of amniotic fluid, in: Amniotic Fluid (A. Scommegna and M. B. Epstein, eds.), p. 23, Wiley, New York.Google Scholar
  299. Seppala, M., Aho, L, Tissari, A., et al., 1972, Radioimmunoassay of oxytocin in amniotic fluid, fetal urine, and meconium during late pregnancy and delivery, Am. J. Obstet. Gynecol. 114:788.PubMedGoogle Scholar
  300. Shah, S., Alderman, M., Queenan, J. Y., et al., 1972, Nondialyzable peptide-bound hydroxy-proline in human amniotic fluid: An indicator of fetal growth, Am. J. Obstet. Gynecol. 114:250.PubMedGoogle Scholar
  301. Sharma, S.D., and Trussell, R. R., 1970, The value of amniotic fluid examination in the assessment of fetal maturity, J. Obstet. Gynaecol. Br. Commonw. 77:215.PubMedCrossRefGoogle Scholar
  302. Shihao, Y., 1981, Prolactin in amniotic fluid and serum of women in early pregnancy, Jugoslav. Ginek. Obstet. 21:116.Google Scholar
  303. Shrand, H., 1972, Vomiting in utero with intestinal atresia, Pediatrics 49:767.PubMedGoogle Scholar
  304. Sindic, M. F., Van Regemorter, N., Verellen-Dumoulin, Ch., et al., 1984, S-100 protein in amniotic fluid of anencephalic fetuses, Prenatal Diagnosis 4:297.PubMedCrossRefGoogle Scholar
  305. Singh, E. J., and Zuspan, F. P., 1974, Content of amniotic fluid prostaglandins in normal, diabetic, and drug-abuse human pregnancy, Am. J. Obstet. Gynecol. 118:358.PubMedGoogle Scholar
  306. Sivakumaran, T., Duncan, M. L., Effer, S. B., et al., 1975, Relationship between Cortisol and lecithin/ sphingomyelin ratios in human amniotic fluid, Am. J. Obstet. Gynecol. 122:291.PubMedGoogle Scholar
  307. Smith, A. L., and Scanlon, J., 1973, Amniotic fluid D(-)-beta-hydroxybutyrate and the dysmature newborn infant, Am. J. Obstet. Gynecol. 115:569.PubMedGoogle Scholar
  308. Smith, A. D., Wald, N. J., Cuckle, H. S., et al., 1979, Amniotic fluid acetylcholinesterase as a possible diagnostic test for neural tube defects in early pregnancy, Lancet 1:685.PubMedCrossRefGoogle Scholar
  309. Soltesz, G., Harris, D., Mackenzie, I. Z., et al., 1985, The metabolic and endocrine milieu of the human fetus and mother at 18–21 weeks of gestation. I. Plasma amino acid concentrations, Pediatr. Res. 19:91.PubMedCrossRefGoogle Scholar
  310. Southern, A. L., Kobayashi, Y., Brenner, P., et al., 1965, Diamine oxidase activity in human maternal and fetal plasma and tissues at parturition, J. Appl. Physiol. 20:1048.Google Scholar
  311. Stevenson, A. C., Davison, B. C. C., and Oakes, M. W., 1976, Genetic Counseling, 2nd ed., Lippincott, Philadelphia.Google Scholar
  312. Stoll, C., Willard, D., Czernichow, P., et al., 1978, Prenatal diagnosis of primary pituitary dysgenesis, Lancet 1:932.PubMedCrossRefGoogle Scholar
  313. Strebel, L., 1960, Immunoelectrophoretic studies of amniotic fluid. Comparison with umbilical cord blood and maternal venous blood, Biol. Neonate 2:55.CrossRefGoogle Scholar
  314. Sugar, J., Dessy, C., Alexander, S., et al., 1980, Estriol-3-glucuronide and estriol-16-glucuronide in amniotic fluid during normal pregnancy, J. Clin. Endocrinol. Metab. 50:137.PubMedCrossRefGoogle Scholar
  315. Sutcliffe, R. G., 1972, Studies on the Protein in Amniotic Fluid, PhD. Thesis, Edinburgh University.Google Scholar
  316. Sutcliffe, R. G., 1975, The nature and origin of the soluble proteins in human amniotic fluid, Biol. Rev. 50:1.PubMedCrossRefGoogle Scholar
  317. Sutcliffe, R. G., and Brock, D. J. H., 1972, Observations on the origins of amniotic fluid enzymes, J. Obstet. Gynaecol. Br. Commonw. 79:902.PubMedCrossRefGoogle Scholar
  318. Sutcliffe, R. G., and Brock, D. J. H., 1973, Immunological studies on the nature and origin of the major proteins in amniotic fluid, J. Obstet. Gynaecol. Br. Commonw. 80:721.PubMedCrossRefGoogle Scholar
  319. Sutcliffe, R. G., Brock, D. J. H., Robertson, J. G., et al., 1972a, Enzymes, in amniotic fluid: A study of specific activity patterns during pregnancy. J. Obstet. Gynaecol. Br. Commonw. 79:895.PubMedCrossRefGoogle Scholar
  320. Sutcliffe, R. G., Brock, D. J. H., and Scrimgeour, J. B., 1972b, Origin of amniotic fluid group-specific component, Nature 238:400.PubMedCrossRefGoogle Scholar
  321. Svigos, J. M., Stewart-Rattray, S. F., and Pridmore, B. R., 1981, Meconium-stained liquor at second trimester amniocentesis—Is it significant? Aust. N. Z. J. Obstet. Gynaecol. 21:5.PubMedCrossRefGoogle Scholar
  322. Swanberg, H., 1950, Histaminase in pregnancy, Acta Physiol. Scand. 23:41.Google Scholar
  323. Symonds, E. M., Williams, S. S., and Cellier, K. M., 1971, Maternal and fetal influences on the acid-base balance of human amniotic fluid, Obstet. Gynecol. 37:742.PubMedGoogle Scholar
  324. Szeto, H. H., Zervoudakis, I. A., Cederqvist, L. L., et al., 1978, Amniotic fluid transfer of meperidine from maternal plasma in early pregnancy, Obstet. Gynecol. 52:59.PubMedGoogle Scholar
  325. Tafari, N., Ross, S. M., Naeye, R. L., et al., 1977, Failure of bacterial growth inhibition by amniotic fluid, Am. J. Obstet. Gynecol. 128:187.PubMedGoogle Scholar
  326. Teichler, D., and Doherty, R. A., 1980, Amniotic fluid secretor typing: Validation for use in prenatal prediction of myotonic dystrophy, Clin. Genet. 18:257.CrossRefGoogle Scholar
  327. Tervila, L., 1964, Transfer of water from maternal blood to amniotic fluid of live and dead fetuses in health and in some pathological conditions of the mother: A study with tritium-labelled water, Ann. Chir. Gynaecol. Fenn. Suppl. 53:131.Google Scholar
  328. Thadepalli, H., Appleman, M. D., Maidman, J. E., et al., 1977, Antimicrobial effect of amniotic fluid against anaerobic bacteria, Am. J. Obstet. Gynecol. 127:250.PubMedGoogle Scholar
  329. Thadepalli, H., Bach, V. T., and Davidson, E. C., Jr., 1978, Antimicrobial effect of amniotic fluid, Obstet. Gynecol. 52:198.PubMedGoogle Scholar
  330. Thadepalli, H., Gangopadhyay, P. K., and Maidman, J. E., 1982, Amniotic fluid analysis for antimicrobial factors, Int. J. Gynaecol. Obstet. 20:65.PubMedCrossRefGoogle Scholar
  331. Thomas, C. R., Lang, E. K., and Lloyd, F. P., 1963, Fetal pyelography—A method for detecting fetal life: A preliminary report, Obstet. Gynecol. 22:335.PubMedGoogle Scholar
  332. Thompson, A. R., 1984, Factor IX and prothrombin in amniotic fluid and fetal plasma: Constraints on prenatal diagnosis of hemophilia B and evidence of proteolysis, Blood 64:867.PubMedGoogle Scholar
  333. Turowska, B., and Bromboszca, A., 1967, ABO group substances in the amniotic fluid, Przegl. Lek. 23:731.PubMedGoogle Scholar
  334. Usategui-Gomez, M., 1974, Immunoglobulins and other proteins in amniotic fluid, in: Amniotic Fluid (S. Natelson, A. Scommegno, and M. B. Epstein, eds.), p. 111, Wiley, New York.Google Scholar
  335. Usategui-Gomez, M., and Morgan, D. F., 1966, Maternal origin of the group specific (Gc) proteins in amniotic fluid, Nature 212:1600.PubMedCrossRefGoogle Scholar
  336. Uuspaa, V. J., 1951, High histaminase activity of human blood in pregnancy and in so-called placental haemochoriatis, Ann. Med. Exp. Biol. Fenn. 29:81.PubMedGoogle Scholar
  337. Uyeno, D., 1919, The physical properties and chemical composition of human amniotic fluid, J. Biol. Chem. 31:71.Google Scholar
  338. Van Diggelen, O. P., Janse, H. C., and Kleijer, W. J., 1983, Disaccharidases in amniotic fluid as a possible prenatal marker for cystic fibrosis, Lancet 1:817.PubMedCrossRefGoogle Scholar
  339. Vernier, J., Piquard, M., Attarl, B., et al., 1969, Etude électrophorétique et immunoélectrophorétique des protéines du liquide amniotique, C. R. Soc. Biol. 163:1835.Google Scholar
  340. Viergiver, E., Stroup, P. E., Scheff, M. F., et al., 1962, Fractionation of amniotic fluid proteins by zone electrophoresis, Obstet. Gynecol. 19:664.PubMedGoogle Scholar
  341. Vikrot, O., 1964, Quantitative determination of plasma phospholipids in pregnant and non-pregnant women, with special reference to lysolecithin, Acta Med. Scand. 175:443.PubMedCrossRefGoogle Scholar
  342. Wagner, G., and Fuchs, F., 1962, The volume of amniotic fluid in the first half of human pregnancy, J. Obstet. Gynaecol. Br. Commonw. 69:131.CrossRefGoogle Scholar
  343. Wallingford, J. C., Milunsky, A., and Underwood, B. A., 1983, Vitamin A and retinol-binding protein in amniotic fluid, Am. J. Clin. Nutr. 38:377.PubMedGoogle Scholar
  344. Walsh, H., Hildebrandt, R., and Prystowsky, H., 1965, Growth inhibition factors in amniotic fluid, Am. J. Obstet. Gynecol. 95:590.Google Scholar
  345. Weiss, P. A. M., Purstner, P., Winter, R., et al., 1984, Insulin levels in amniotic fluid of normal and abnormal pregnancies, Obstet. Gynecol. 63:371.PubMedGoogle Scholar
  346. Westergard, J. G., Cheminitz, J., Teisner, B., et al., 1983, Pregnancy-associated plasma protein A: A possible marker in the classification and prenatal diagnosis of Cornelia de Lange syndrome, Prenat. Diagn. 3:225.CrossRefGoogle Scholar
  347. Wiederschain, G. Y., Rosenfeld, E. L., Brusilovsky, A. I., et al., 1971, L-Fucosidase and other glycosi-dases in human placenta, fetus liver, and amniotic fluid at various stages of gestation, Clin. Chim. Acta 35:99.PubMedCrossRefGoogle Scholar
  348. Wild, A. E., 1961, The association between protein and bilirubin in liquor amnii, Clin. Sci. 21:221.PubMedGoogle Scholar
  349. Wilfert, C. M., and Gradoville, M. L., 1974, In vitro viral studies of cells grown from human amniotic fluid samples, Am. J. Obstet. Gynecol. 118:1073.PubMedGoogle Scholar
  350. Wisniewski, L., Jezuita, J., Bogoniowska, Z., et al., 1983, Prenat. Endocrinol. 57:693.Google Scholar
  351. Perlman, M., 1973, Golden liquor amnii, Lancet 1:556.PubMedCrossRefGoogle Scholar
  352. Petrucha, R. A., Goebelsmann, U., Hung, T. T., et al., 1983, Amniotic fluid ß-endorphin and ß-lipotropin concentrations during the second and third trimesters, Am. J. Obstet. Gynecol. 146:644.PubMedGoogle Scholar
  353. Pettit, B. R., Graham, S. K., and Blau, K., 1980, The analysis of hexitols in biological fluid by selected ion monitoring, Biomed. Mass Spectrom. 7:309.PubMedCrossRefGoogle Scholar
  354. Phillips, L. L., and Davidson, E. C., 1972, Procoagulant properties of amniotic fluid, Am. J. Obstet. Gynecol. 113:911.PubMedGoogle Scholar
  355. Phimister, G. H., and Marshall, R. D., 1983, Tamm-Horsfall glycoprotein in human amniotic fluid, Clin. Chim. Acta 128:261.PubMedCrossRefGoogle Scholar
  356. Pinkus, G. S., and Pinkus, J. L., 1970, Fluorometric determination of total estrogens in amniotic fluid of normal and complicated pregnancies, Obstet. Gynecol. 36:528.PubMedGoogle Scholar
  357. Pitkin, R. M., and Reynolds, W. A., 1975, Fetal ingestion and metabolism of amniotic fluid protein, Am. J. Obstet. Gynecol. 23:356.Google Scholar
  358. Pitkin, R. M., and Swirek, S. J., 1967, Amniotic fluid creatinine, Am. J. Obstet. Gynecol. 98:1135.PubMedGoogle Scholar
  359. Plentl, A. A., and Hutchinson, D. L., 1953, Determination of deuterium exchange rates between maternal circulation and amniotic fluid, Proc. Soc. Exp. Biol. Med. 82:681.PubMedGoogle Scholar
  360. Pocknee, R. C., and Abramovich, D. R., 1982, Origin and levels of trypsin in amniotic fluid throughout pregnancy, Br. J. Obstet. Gynecol. 89:142.CrossRefGoogle Scholar
  361. Poenaru, L., Vinet, M. C., and Dreyfus, J. C., 1981, Human amniotic fluid a-glucosidase, Clin. Chim. Acta 117:53.PubMedCrossRefGoogle Scholar
  362. Pokiodova, N. V., Babaian, S.S., and Ermolieva, Z. V., 1971, Vydelenie lizotsima iz platsenty cheloveka, Antibiotiki 16:456.PubMedGoogle Scholar
  363. Pomerance, W., Biezenski, J. J., Moltz, A., et al., 1971, Origin of amniotic fluid lipids. II. Abnormal pregnancy, Obstet. Gynecol. 38:379.PubMedGoogle Scholar
  364. Potier, M., Dallaire, L., and Melançon, S. B., 1974, Amniotic fluid a-galactosidase activity: An indicator of gestational age, Gynecol. Invest. 5:306.PubMedCrossRefGoogle Scholar
  365. Potier, M., Dallaire, L., and Melançon, S. B., 1975, Occurrence and properties of fetal intestinal glycosidases (disaccharidases) in human amniotic fluid, Biol. Neonate 27:141.PubMedCrossRefGoogle Scholar
  366. Potier, M., Melançon, S. B., and Dallaire, L., 1976, Fetal intestinal disaccharidases in human amniotic fluid, Biomedecine 25:167.PubMedGoogle Scholar
  367. Potier, M., Boire, G., Dallaire, L., et al., 1977a, N-Acetyl-ß-hexosaminidase isoenzymes of amniotic fluid and maternal serum: Their relevance to prenatal diagnosis of the GM2 gangliosidoses, Clin. Chim. Acta 76:309.PubMedCrossRefGoogle Scholar
  368. Potier, M., Dallaire, L., and Melançon, S. B., 1977b, Prenatal detection of intestinal obstruction by disaccharidase assay in amniotic fluid, Lancet 2:982.PubMedCrossRefGoogle Scholar
  369. Potier, M., Melançon, S. B., and Dallaire, L., 1978, Developmental patterns of intestinal disaccharidases in human amniotic fluid, Am. J. Obstet. Gynecol. 131:73.PubMedGoogle Scholar
  370. Potier, M., Guay, P., Lamothe, P., et al., 1979, Origin and developmental patterns of lactase and other glycosidases in sheep amniotic and allantoic fluid, J. Reprod. Fertil. 57:49.PubMedCrossRefGoogle Scholar
  371. Potier, M., Morin, P. R., Melançon, S. B., et al., 1984, Differential stabilities of fetal intestinal disaccharidases determine their relative amounts released into amniotic fluid, Biol. Neonate 45:257.PubMedCrossRefGoogle Scholar
  372. Potier, M., Cousineau, J., Michaud, L., et al., 1986, Fetal intestinal microvilli in human amniotic fluid, Prenat. Diag. (in press).Google Scholar
  373. Potter, E. L., 1965, Bilateral absence of ureters and kidneys. A report of 50 cases, J. Obstet. Gynaecol. Br. Commonw. 25:3.Google Scholar
  374. Prevedourakis, C., Stringou-Charlabis, E., and Kaskarelis, D., 1971, Bacterial invasion of amniotic cavity during pregnancy and labor, Obstet. Gynecol. 37:459.PubMedGoogle Scholar
  375. Prevedourakis, C., Koumentakou, E., Zolotas, J., et al., 1976, E. coli growth inhibition by amniotic fluid, Acta Obstet. Gynecol. Scand. 55:245.PubMedCrossRefGoogle Scholar
  376. Prezestwor, E., 1964, Distribution of ABH group substances in amniotic fluid, Poznan, Tow. Przyj. Nauk 29:197.Google Scholar
  377. Pritchard, J. A., 1965, Deglutition by normal and anencephalic fetuses, Obstet. Gynecol. 25:289.PubMedGoogle Scholar
  378. Pritchard, J. A., 1966, Fetal swallowing and amniotic fluid volume, Obstet. Gynecol. 28:606.PubMedGoogle Scholar
  379. Putkonen, T., 1930, Ueber die gruppenspezifischen Eigenschaften verschiedener Korperflüssigkeiten, Acta Soc. Med. Fenn. Duodecim Ser. A 14:113.Google Scholar
  380. Queenan, J. T., Gadow, E. C., Bachner, P., et al., 1970, Amniotic fluid proteins in normal and Rh-sensitized pregnancies, Am. J. Obstet. Gynecol. 108:406.PubMedGoogle Scholar
  381. Queenan, J. T., Thompson, W., Whitfield, C. R., et al., 1972, Amniotic fluid volumes in normal pregnancies, Am. J. Obstet. Gynecol. 114:34.PubMedGoogle Scholar
  382. Reid, D. W. J., Campbell, D. J., and Yakymyshyn, L. Y., 1971, Quantitative amino acids in amniotic fluid and maternal plasma in early and late pregnancy, Am. J. Obstet. Gynecol. 111:251.PubMedGoogle Scholar
  383. Renwick, J. H., and Boiling, D. R., 1971, An analysis procedure illustrated on a triple linkage of use for prenatal diagnosis of myotonic dystrophy, J. Med. Genet. 8:399.PubMedCrossRefGoogle Scholar
  384. Renwick, J. H., and Lawler, S. D., 1955, Genetical linkage between the ABO and nail-patella loci, Ann. Hum. Genet. 19:312.PubMedCrossRefGoogle Scholar
  385. Renwick, J. H., Bundey, S. E., Ferguson-Smith, M. A., et al., 1971, Confirmation of linkage of the loci for myotonic dystrophy and ABH selection, J. Med. Genet. 8:407.PubMedCrossRefGoogle Scholar
  386. Rhodes, P., 1966, The volume of liquor amnii in early pregnancy, J. Obstet. Gynaecol. Br. Commonw. 73:23.PubMedCrossRefGoogle Scholar
  387. Risteli, L., Autic-Harmainen, H., Von Koskull, H., et al., 1984, Basement membrane proteins in human amniotic fluid, Clin. Genet. 26:271.CrossRefGoogle Scholar
  388. Rivett, L. C., 1946, Hydramnios, Am. J. Obstet. Gynecol. 52:890.PubMedGoogle Scholar
  389. Robertson, A. F., and Sprecher, H., 1968, A review of human placental lipid metabolism and transport, Acta Paediatr. Scand. Suppl. 183:3.CrossRefGoogle Scholar
  390. Robinson, J. D., Judd, H. L., Young, P. E., et al., 1977, Amniotic fluid androgens and estrogens in midgestation, J. Clin. Endocrinol. Metab. 45:755.PubMedCrossRefGoogle Scholar
  391. Ron, M., Cohen, T., Yaffe, H., et al., 1982, The clinical significance of blood-contaminated midtrimester amniocentesis, Acta Obstet. Gynecol. Scand. 61:43.PubMedCrossRefGoogle Scholar
  392. Roopnarinesingh, S., 1970, Amniotic fluid creatinine in normal and abnormal pregnancies, J. Obstet. Gynaecol. Br. Commonw. 77:785.PubMedCrossRefGoogle Scholar
  393. Roux, J. F., Nakamura, J., and Frosolono, M., 1974, Fatty acid composition and concentration of lecithin in the acetone fraction of amniotic fluid phospholipids, Am. J. Obstet. Gynecol. 119:838.PubMedGoogle Scholar
  394. Rozansky, S., Persky, B., and Bercovici, B., 1962, Antibacterial action of human cervical mucus, Proc. Soc. Exp. Biol. Med. 110:876.PubMedGoogle Scholar
  395. Ruelland, A., Mention, J. E., Perrot, Y., et al., 1982, The levels of apolipoprotein A in liquor in normal and pathological pregnancies, J. Gynecol. Obstet. Biol. Reprod. 11:241.Google Scholar
  396. Rule, A. H., Lawrence, D., Hager, H. J., et al., 1971, IgA: Presence in meconium obtained from patients with cystic fibrosis, Pediatrics 48:601.PubMedGoogle Scholar
  397. Ruth, R. E., and Goldsmith, S. K., 1981, Interaction between zinc deprivation and acute ethanol intoxication during pregnancy in rats, J. Nutr. 111:2034.PubMedGoogle Scholar
  398. Salafsky, I. S., and Nadler, H. L., 1971, Intracellular organelles and enzymes in cell-free amniotic fluid, Am. J. Obstet. Gynecol. 111:1046.PubMedGoogle Scholar
  399. Salmon, J., Lambotte, R., and Sroliar, V., 1962, Etude par immunofluorescence de la sécrétion du liquide amniotique humain, Arch. Int. Physiol. Biochim. 70:731.PubMedCrossRefGoogle Scholar
  400. Sarkany, I., and Gaylarde, C. C., 1968, The effect of amniotic fluid in bacterial growth, Br. J. Dermatol. 80:241.PubMedCrossRefGoogle Scholar
  401. Schenker, J. G., Ben-David, M., and Polishuk, W. Z., 1975, Prolactin in normal pregnancy: Relationship of maternal, fetal, and amniotic fluid levels, Am. J. Obstet. Gynecol. 123:834.PubMedGoogle Scholar
  402. Schlievert, P., Johnson, W., and Galask, R. P., 1976a, Bacterial growth inhibition by amniotic fluid. VI. Evidence for a zinc-peptide antibacterial system, Am. J. Obstet. Gynecol. 125:906.PubMedGoogle Scholar
  403. Schlievert, P., Johnson, W., and Galask, R. P., 1976b, Bacterial growth inhibition by amniotic fluid. V. Phosphate-to-zinc ratio as a predictor of bacterial growth-inhibitory activity, Am. J. Obstet. Gynecol. 125:899.PubMedGoogle Scholar
  404. Schumacher, G. F. B., and Pearl, M. J., 1969, Cyclic changes of muramidase (lysozyme in cervical mucus), J. Reprod. Med. 3:105.Google Scholar
  405. Schweitzer, M., and Giroud, C. J. P., 1971, A comparison of the pattern of steroid glucuronides and sulfates in maternal plasma, umbilical cord plasma, and amniotic fluid. II, J. Clin. Endocrinol. Metab. 33:793.PubMedCrossRefGoogle Scholar
  406. Sciarra, J. J., Tagatz, G. E., Notation, A. D., et al., 1974, Estriol and estetrol in amniotic fluid, Am. J. Obstet. Gynecol. 118:626.PubMedGoogle Scholar
  407. Scott, C. R., Teng, C. C., Sagerson, R. N., et al., 1972, Amino acids in amniotic fluid: Changes in concentrations during the first half of pregnancy, Pediatr. Res. 6:659.PubMedCrossRefGoogle Scholar
  408. Wolf, R. O., and Taussig, L. M., 1973, Human amniotic fluid isoamylases: Functional development of fetal pancreas and salivary glands, Obstet. Gynecol. 41:337.PubMedGoogle Scholar
  409. Wu, C. H., Mennuti, M. T., and Mikhail, G., 1979, Free and protein-bound steroids in amniotic fluid of midpregnancy, Am. J. Obstet. Gynecol. 133:666.PubMedGoogle Scholar
  410. Zondek, T., Mansfield, M. D., and Zondek, L. H., 1977, Amniotic fluid testosterone and fetal sex determination in the first half of pregnancy, Br. J. Obstet. Gynaecol 84:714.PubMedGoogle Scholar

Copyright information

© Aubrey Milunsky 1986

Authors and Affiliations

  • Louis Dallaire
    • 1
    • 2
  • Michel Potier
    • 1
    • 2
  1. 1.Department of PediatricsUniversity of MontrealMontrealCanada
  2. 2.Section of Medical GeneticsSte-Justine HospitalMontrealCanada

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