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α-Melanotropin Analogues for Biomedical Applications

  • Mac E. Hadley
  • Victor J. Hruby
  • Dhirendra N. Chaturvedi
  • Tomi K. Sawyer
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)

Abstract

Until recently, the melanotropins were of interest mainly to comparative physiologists, since their role as hormones was believed to be restricted mainly to the control of integumental color changes in lower vertebrates. It is now realized that the melanotropic peptides are also found localized to the nervous system (O’Donohue and Dorsa, 1982), where as neurohormones they may serve a number of central nervous system functions (Beckwith and Sandman, 1982). Furthermore, localization of melanotropins to peripheral organs suggests that these peptides, possibly functioning as local hormones, subserve other as yet undefined physiological roles (Chen et al., 1984).

Keywords

Melanoma Cell Tyrosinase Activity Central Nervous System Function Fragment Analogue Melanoma Tyrosinase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Mac E. Hadley
    • 1
  • Victor J. Hruby
    • 2
  • Dhirendra N. Chaturvedi
    • 3
  • Tomi K. Sawyer
    • 4
  1. 1.Department of AnatomyUniversity of ArizonaTucsonUSA
  2. 2.Department of ChemistryUniversity of ArizonaTucsonUSA
  3. 3.Vega Biotechnologies, Inc.TucsonUSA
  4. 4.Biopolymer Chemistry/BiotechnologyThe Upjohn CompanyKalamazooUSA

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