Relationship of Clinical to Basic Research with Peptides as lllustrated by MSH

  • Abba J. Kastin
  • Richard D. Olson
  • James E. Zadina
  • William A. Banks
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)


Many of the principles that are now influencing the field of brain peptides were established more than a decade ago with melanocyte-stimulating hormone (MSH). A series of studies with MSH demonstrated not only the multiple actions of peptides but also the complex relationship of basic to clinical investigation. The actions of MSH, therefore, can be considered a prototype for those of other peptides. The present review discusses several of these actions with examples taken from our own experience. Where possible, clinical studies are emphasized even though most of our research has involved laboratory animals.


Reversal Learning ACTH Release Active Avoidance Response Retarded Adult Brain Peptide 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Abba J. Kastin
    • 1
  • Richard D. Olson
    • 1
  • James E. Zadina
    • 1
  • William A. Banks
    • 1
  1. 1.Veterans Administration Medical CenterUniversity of New Orleans, and Tulane University School of MedicineNew OrleansUSA

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