Relationship of Clinical to Basic Research with Peptides as lllustrated by MSH
Many of the principles that are now influencing the field of brain peptides were established more than a decade ago with melanocyte-stimulating hormone (MSH). A series of studies with MSH demonstrated not only the multiple actions of peptides but also the complex relationship of basic to clinical investigation. The actions of MSH, therefore, can be considered a prototype for those of other peptides. The present review discusses several of these actions with examples taken from our own experience. Where possible, clinical studies are emphasized even though most of our research has involved laboratory animals.
KeywordsReversal Learning ACTH Release Active Avoidance Response Retarded Adult Brain Peptide
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