Neuropeptides and Adrenal Steroidogenesis
There has been a great deal of attention directed toward the source, regulation, and function of the peptides derived from the 31 -kD proadrenocorticotropin-endorphin precursor in the pituitary (Barker, 1977; Krieger, 1980; Numa and Nakanishi, 1980). The parent molecule is metabolized to an amino-terminal segment, referred to as the 16K fragment, the 39-amino-acid hormone ACTH, and a 91-amino-acid peptide, β-lipotropin (β-LPH). In turn, ACTH and β-LPH may be metabolized to the smaller peptides, including α-melanotropin (α-MSH) from ACTH and β-MSH and βendorphin from β-lipotropin.
KeywordscAMP Production Aldosterone Production Adrenal Steroidogenesis Steroidogenic Response Pituitary Peptide
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