Modulation of Carboxypeptidase Processing Enzyme Activity
Regulation of peptide hormone biosynthesis can occur at several cellular levels: transcription of the peptide hormone gene, RNA processing, translation of the mature mRNA, and posttranslational processing of the precursor form of the peptide. Among these steps, the role of the posttranslational processing enzymes in the control of peptide hormone formation has not yet been determined. These enzymes represent an important potential point of regulation, since it is at this step that the biologically inactive peptide hormone precursor is converted to its final smaller biologically active form.
KeywordsSecretory Granule Chromaffin Cell Peptide Hormone Processing Enzyme Chromaffin Granule
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