Modulation of Carboxypeptidase Processing Enzyme Activity

  • Vivian Y. H. Hook
  • Lee E. Eiden
  • Rebecca M. Pruss
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)


Regulation of peptide hormone biosynthesis can occur at several cellular levels: transcription of the peptide hormone gene, RNA processing, translation of the mature mRNA, and posttranslational processing of the precursor form of the peptide. Among these steps, the role of the posttranslational processing enzymes in the control of peptide hormone formation has not yet been determined. These enzymes represent an important potential point of regulation, since it is at this step that the biologically inactive peptide hormone precursor is converted to its final smaller biologically active form.


Secretory Granule Chromaffin Cell Peptide Hormone Processing Enzyme Chromaffin Granule 


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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Vivian Y. H. Hook
    • 1
    • 2
  • Lee E. Eiden
    • 1
  • Rebecca M. Pruss
    • 1
  1. 1.Laboratory of Cell BiologyNational Institute of Mental HealthBethesdaUSA
  2. 2.Department of BiochemistryUniformed Services University of the Health SciencesBethesdaUSA

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