[Norleucine3,6]-Substituted Cholecystokinin Octapeptide Analogues

Design, Synthesis, and Comparative Structure-Activity Relationships in Guinea Pig Brain, Lung, and Pancreas Tissues
  • Tomi K. Sawyer
  • Douglas J. Staples
  • Robert A. Lahti
  • Peggy J. K. D. Schreur
  • Anita E. Wilkerson
  • Henry H. Holzgrefe
  • Stuart Bunting
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)


Cholecystokinin octapeptide (CCK-8, Fig. 1) is a neurogastric peptide hormone and neurotransmitter that possesses multiple biological activities (Table I). Cholecystokinin octapeptide is one of several molecular variants (e.g., CCK-39, CCK33, CCK-12, and CCK-8) existing within a family of CCK peptides that have been identified in both the central and peripheral nervous systems as well as in the gastrointestinal tract. The specific details related to the discovery, distribution, biosynthesis, metabolism, biological activities in vitro and in vivo, and mechanisms of action of CCK peptides have been excellently reviewed recently (Mutt, 1980; Kelley and Dodd, 1981: Williams, 1982; Morley, 1982; Beinfeld, 1983; Dockray, 1983).


Pancreatic Acinus Amylase Release Cholecystokinin Receptor Cholecystokinin Octapeptide Cholecystokinin Receptor Antagonist 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Tomi K. Sawyer
    • 1
  • Douglas J. Staples
    • 1
  • Robert A. Lahti
    • 2
  • Peggy J. K. D. Schreur
    • 2
  • Anita E. Wilkerson
    • 2
  • Henry H. Holzgrefe
    • 3
  • Stuart Bunting
    • 3
  1. 1.Biopolymer Chemistry/BiotechnologyThe Upjohn CompanyKalamazooUSA
  2. 2.CNS Diseases ResearchThe Upjohn CompanyKalamazooUSA
  3. 3.Lipids ResearchThe Upjohn CompanyKalamazooUSA

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