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Localization of Neural and Endocrine Peptides

  • J. M. Polak
  • S. R. Bloom
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)

Abstract

The realization that a massive number of active peptides are present in the innervation and endocrine tissue of most organ systems of the body has opened up a new facet of endocrinology, that of the study of the so-called “diffuse neuroendocrine system” (Polak and Bloom, 1983). The concept of a “diffuse endocrine system” is not new. Feyrter (1938, 1953) described a series of cells that reacted poorly with conventional histological staining techniques. These cells were dispersed throughout the body, intermingled with strongly stained cells. They also became dark after treatment of the tissue with silver salts (argyrophilia). The terms “clear cells” or “diffuse endocrine system” were the proposed. The advent of more appropriate technology led Pearse to identify these cells under the umbrella of the APUD (amine precursor uptake and decarboxylation) system (see review by Pearse, 1984) and Fujita (1977) to describe them as the “paraneuronal” system. Both Pearse and Fujita highlighted the close association between these specialized endocrine cells and neural elements.

Keywords

Glial Fibrillary Acidic Protein Atrial Natriuretic Peptide Secretory Granule Endocrine Cell Coeliac Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • J. M. Polak
    • 1
  • S. R. Bloom
    • 1
  1. 1.Departments of Histochemistry and MedicineRoyal Postgraduate Medical School, Hammersmith HospitalLondonEngland

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