Advertisement

A CRF-Producing and -Secreting Tumor of the Lung

  • G. Kahaly
  • T. Strack
  • U. Krause
  • J. Schrezenmeir
  • J. Beyer
  • W. Ormanns
  • J. Dämmrich
  • C. Maser-Gluth
  • P. Vecsei
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)

Abstract

Corticotropin-releasing factor (CRF) has recently been isolated from ovine hypothalamus, characterized chemically, and synthesized. Upton and Amatruda (1971) first suggested that CRF-like activity occurred in neoplastic tissues, and Hashimoto et al. (1980) subsequently detected CRF-like activity in an extract of an ACTHproducing nephroblastoma. Recently, Carey et al. (1984) and Asa et al. (1984) used immunocytochemical techniques to demonstrate CRF in postmortem tumor material obtained from patients with a carcinoma of the prostate and an intrasellar gangliocytoma.

Keywords

Adrenal Vein Innominate Vein Cutaneous Metastasis Tissue Polypeptide Antigen Urinary Steroid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Asa, S., Kovacs, K., Tindall, G. T., Barrow, D. L., Horvath, E., and Vecsei, P., 1984, Cushing’s disease associated with an intrasellar gangliocytoma producing corticotropin-releasing factor, Ann. Intern. Med. 101:789–793.PubMedGoogle Scholar
  2. Carey, R. M., Varma, S. K., Drake, C., Thorner, M. O., Kovacs, K., Rivier, J., and Vale, W., 1984, Ectopic secretion of corticotropin-releasing factor as a cause of Cushing’s syndrome: A clinical, morphologie and biochemical study, N. Engl. J. Med. 311:13–20.PubMedCrossRefGoogle Scholar
  3. Chrousos, G. P., Shulte, H. M., Oldfield, E. H., Gold, P. W., Cutler, G. B., and Loriaux, D. L., 1984, The corticotropin releasing factor stimulation test, N. Engl. J. Med. 310:622–626.PubMedCrossRefGoogle Scholar
  4. Hashimoto, K., Takahara, J., Ogawa, N., Yunoki, S., Ofugi, T., Arata, A., Kanda, S., and Terada, K., 1980, Adrenocorticotropin, β-lipotropin, β-endorphin and corticotropin releasing factor-like activity in an adrenocorticotropin producing nephroblastoma, J. Clin. Endocrinol. Metab. 50:461–465.PubMedCrossRefGoogle Scholar
  5. Maser-Gluth, C., Toygar, A., and Vecsei, P., 1984, Time course of plasma corticosterone, 18-hydroxy-corticosterone and aldosterone concentration following CRF administration in the rat: A fact of corticotrophin inhibition, Life Sci. 35:879–884.PubMedCrossRefGoogle Scholar
  6. Nicholosn, W., DeCherney, G., Jackson, R., DeBold, R., Uderman, H., Alexander, A., Rivier, J., Vale, W., and Orth, D., 1983, Plasma distribution, disappearance half-time, metabolic clearance rate and degradation of synthetic ovine corticotropin releasing factor in man, J. Clin. Endocrinol. Metab. 57:1263–1269.CrossRefGoogle Scholar
  7. Upton, G. V., and Amatruda, T., 1971, Evidence for the presence of tumor peptides with corticotropin releasing factor-like activity in the ectopic ACTH syndrome, N. Engl. J. Med. 285:419–423.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • G. Kahaly
    • 1
  • T. Strack
    • 1
  • U. Krause
    • 1
  • J. Schrezenmeir
    • 1
  • J. Beyer
    • 1
  • W. Ormanns
    • 2
  • J. Dämmrich
    • 2
  • C. Maser-Gluth
    • 3
  • P. Vecsei
    • 3
  1. 1.Department of EndocrinologyUniversity of MainzMainzFederal Republic of Germany
  2. 2.Department of PathologyUniversity of WürzburgWürzburgFederal Republic of Germany
  3. 3.Department of PharmacologyUniversity of HeidelbergHeidelbergFederal Republic of Germany

Personalised recommendations