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Bombesin/Gastrin-Releasing Peptide Stimulation of Small-Cell Lung Cancer Clonal Growth

  • Desmond N. Carney
  • Terry W. Moody
  • Frank Cuttitta
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)

Abstract

Small-cell lung cancer (SCLC) accounts for 20-25% of all new cases of primary lung cancer. Unlike the other major histological subtypes of lung cancer (collectively referred to as non-SCLC), SCLC is highly sensitive to both chemotherapy and radiation therapy. With combination chemotherapy a clinical response will be observed in up to 95% of all patients, and complete disappearance of all known tumor is seen in 40-50% of patients (Morstyn et al., 1984). However, in spite of the early dramatic responses observed in most patients, the vast majority will relapse with SCLC, and fewer than 10% of all patients will achieve long-term disease-free survival. The median survival for all patients is 10-11 months. Thus, there is a need to develop alternative approaches to the treatment of this tumor type.

Keywords

Small Cell Lung Cancer Small Cell Carcinoma Clonal Growth Small Cell Lung Cancer Cell Continuous Cell Line 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Desmond N. Carney
    • 1
  • Terry W. Moody
    • 2
  • Frank Cuttitta
    • 3
  1. 1.Mater HospitalDublin 7Ireland
  2. 2.Department of BiochemistryThe George Washington University School of Medicine and Health SciencesUSA
  3. 3.NCI-Navy Medical Oncology BranchNational Naval Medical CenterBethesdaUSA

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