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Peptides and Their Receptors in Oat Cell Carcinoma

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Neural and Endocrine Peptides and Receptors

Abstract

Oat cell carcinoma or small-cell lung cancer (SCLC) comprises about 25% of the 110,000 new cases of malignant lung cancer each year (Bunn et al., 1977). Many of the patients are responsive to chemo- and/or radiation therapy, but many of the diagnosed cases are far advanced, with the cancer having undergone metastases from the lung to the liver, lymph nodes, bone, and/or brain.

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References

  • Berridge, M. J., 1984, Inositol triphosphate and diacylglycerol as second messengers, Biochem. J. 220:345–360.

    PubMed  CAS  Google Scholar 

  • Bunn, P. A., Cohen, M. H., Ihde, D. C., Fossieck, B. E., Matthews, M. J., and Minna, J. D., 1977, Advances in small cell bronchogenic carcinoma, Cancer Treat. Rep. 61:333–342.

    PubMed  Google Scholar 

  • Carney, D., Bunn, P., Gazdar, A., Pagan, J., and Minna, J., 1981, Selective growth in serum-free hormone-supplemented medium of tumor cells obtained by biopsy from patients with small cell carcinoma of the lung, Proc. Natl. Acad. Sci. U.S.A. 78:3185–3189.

    Article  PubMed  CAS  Google Scholar 

  • Carney, C. N., Oie, H., Moody, T., Gazdar, A., Cuttitta, F., and Minna, J. D., 1983, Bombesin: An autocrine growth factor for human small cell lung cancer, Clin. Res. 31:404A.

    Google Scholar 

  • Cuttitta, F., Carney, D. N., Mulshine, J., Moody, T. W., Fedorko, J., Fischler, A., and Minna, J. D., 1985, Bombesin-like peptides can function as autocrine growth factors in human small cell lung cancer, Nature 316:823–826.

    Article  PubMed  CAS  Google Scholar 

  • Erisman, M. R., Linnoila, O., Hernandez, R., DiAugustine, R., and Lazarus, L., 1982, Human lung small-cell carcinoma contains bombesin, Proc. Natl. Acad. Sci. U.S.A. 79:2379–2383.

    Article  PubMed  CAS  Google Scholar 

  • Gazdar, A., Carney, D., Rü ssel, E., Sims, H., Baylin, S., Bunn, P., Guccion, J., and Minna, J., 1979, Establishment of continuous, clonable, cultures of small cell carcinoma of the lung which have amine precursor uptake and decarboxylation cell properties, Cancer Res. 40:3502–3507.

    Google Scholar 

  • Jensen, R., Moody, T., Pert, C., Rivier, J., and Gardner, J., 1978, Interaction of bombesin and litorin with specific membrane receptors on pancreatic acinar cells, Proc. Natl. Acad. Sci. U.S.A. 75:6139–6143.

    Article  PubMed  CAS  Google Scholar 

  • Little, C. D., Nan, M. N., Carney, D. N., Gazdar, A. F., and Minna, J. D., 1983, Amplification and expression of the c-myc oncogene in human lung cancer cell lines, Nature 306:194–196.

    Article  PubMed  CAS  Google Scholar 

  • Marangos, P., Gazdar, A., and Carney, D., 1982, Neuron specific enolase in human small cell carcinoma cultures, Cancer Lett. 15:67–71.

    Article  PubMed  CAS  Google Scholar 

  • Moody, T., Pert, C., Gazdar, A., Carney, D., and Minna, J., 1981, High levels of intracellular bombesin characterize human small cell lung carcinoma, Science 214:1246–1248.

    Article  PubMed  CAS  Google Scholar 

  • Moody, T., Russel, E., O’Donohue, T., Linden, C., and Gazdar, A., 1983, Bombesin-like peptides in small cell lung cancer: Biochemical characterization and secretion from a cell line, Life Sci. 32:487–493.

    Article  PubMed  CAS  Google Scholar 

  • Moody, T. W., Carney, D. N., Korman, L. Y., Gazdar, A. F., and Minna, J. D., 1985a, Neurotensin is produced by and secreted from classic cell lung cancer cells, Life Sci. 36:1727–1732.

    Article  PubMed  CAS  Google Scholar 

  • Moody, T. W., Carney, D. N., Cuttitta, F., Quattrocchi, K., and Minna, J. D., 1985b, High affinity receptors for bombesin/GRP-like peptides on human small cell lung cancer, Life Sci. 37:105–113.

    Article  PubMed  CAS  Google Scholar 

  • Pert, C. B., and Schumacher, U. K., 1982, Plasma bombesin concentrations in patients with extensive small cell carcinoma of the lung, Lancet 1:509.

    Article  PubMed  CAS  Google Scholar 

  • Pettengill, O. S., Bacopoulos, N. G., and Sorenson, G. D., 1982, Biogenic amine metabolites in human in tumor cells: Histochemical and mass-spectrographic demonstration, Life Sci. 30:1355–1360.

    Article  PubMed  CAS  Google Scholar 

  • Rivier, J., and Brown, M., 1978, Bombesin, bombesin analogues and related peptides: Effects on thermoregulation, Biochemistry 17:1766–1771.

    Article  PubMed  CAS  Google Scholar 

  • Roth, K. A., Evans, C. J., Weber, E., Barchas, J. D., Bostwick, D. G., and Bensch, K. G., 1983, Gastrin-releasing peptide-related peptides in a human malignant lung carcinoid tumor, Cancer Res. 43:5411–5415.

    PubMed  CAS  Google Scholar 

  • Rozengurt, E., and Sinnet-Smith, J., 1983, Bombesin stimulation of DNA synthesis and cell division in cultures in Swiss 3T3 cells, Proc. Natl. Acad. Sci. U.S.A. 80:2936–2940.

    Article  PubMed  CAS  Google Scholar 

  • Sorenson, G. D., Pettengill, O. S., Cate, C. C., Ghatei, M. A., Molyneux, K. E., Gosselin, E. J., and Bloom, S. R., 1983, Bombesin and calcitonin secretion by pulmonary carcinoma is modulated by cholinergic receptors, Life Sci. 33:1939–1944.

    Article  PubMed  CAS  Google Scholar 

  • Spindel, E. R., Chin, W. W., Price, J., Rees, L. H., Besser, G. M., and Habener, J. F., 1984, Cloning and characterization of cDNAs encoding human gastrin-releasing peptide, Proc. Natl. Acad. Sci. U.S.A. 81:5699–5703.

    Article  PubMed  CAS  Google Scholar 

  • Tamai, S., Kameya, T., Yamaguchi, K., Yanai, N., Abe, K., Yanaihara, N., Yamazaki, N., Yamazaki, H., and Kageyama, K., 1983, Peripheral lung carcinoid tumor producing predominantly gastrin-releasing peptide (GRP), Cancer 52:273–281.

    Article  PubMed  CAS  Google Scholar 

  • Willey, J. G., Lechner, J. F., and Harris, C. C., 1984, Bombesin and the C-terminal tetradecapeptide of gastrin-releasing peptide are growth factors for normal human bronchial epithelial cells, Exp. Cell Res. 153:245–248.

    Article  PubMed  CAS  Google Scholar 

  • Wood, S., Wood, J., Ghatei, M., Lee, U., Shaughnessy, D., and Bloom, S., 1981, Bombesin, 5somatostatin and neurotensin-like immunoreactivity in bronchial carcinoma, J. Clin. Endocrinol. 53:1310–1312.

    Article  CAS  Google Scholar 

  • Wood, S. M., Wood, J. R., Ghatei, M. A., Sorenson, G. D., and Bloom, S. R., 1982, Is bombesin a tumour marker for small cell carcinoma? Lancet 1:690–691.

    PubMed  CAS  Google Scholar 

  • Yamiguchi, K., Abe, K., Kameya, T., Actachi, I., Taguchi, S., Otsuba, K., and Yanaihara, N., 1983, Production and molecular size heterogeneity of immunoreactive gastrin-releasing peptide in fetal and adult lungs and primary lung tumors, Cancer Res. 43:3932–3937.

    Google Scholar 

  • Yesner, R., 1978, Hormone production in small cell lung cancer, Pathol. Ann. 13:207–240.

    Google Scholar 

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© 1986 Plenum Press, New York

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Moody, T.W., Korman, L.Y., Carney, D.N. (1986). Peptides and Their Receptors in Oat Cell Carcinoma. In: Moody, T.W. (eds) Neural and Endocrine Peptides and Receptors. GWUMC Department of Biochemistry Annual Spring Symposia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5152-8_28

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  • DOI: https://doi.org/10.1007/978-1-4684-5152-8_28

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5154-2

  • Online ISBN: 978-1-4684-5152-8

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