Physiological Effects of Transforming Growth Factor α
From the conditioned medium of transformed cells, two types of mitogenic polypeptides (α and β) known as transforming growth factors were isolated and characterized. Because of their origin and their abilities to confer phenotypic transformation of cells in culture, much of the studies of transforming growth factors have been focused on their roles in malignancy and their relationship with the oncogenes (for a review, see Brown and Blakeley, 1984; Sporn and Roberts, 1985). However, because of the scarcity of these growth factors from natural sources, little is known about their physiological effects in animals. Recently, our laboratory has synthesized highly purified rat and human transforming growth factor (TGFα). These synthetic materials have been vigorously characterized and found to be indistinguishable from those obtained from the natural source. The availability of these growth factors has made it possible for the first time to study the physiological effects in whole animals. Here, we report our results using the synthetic TGFα.
KeywordsEpidermal Growth Factor Receptor Epidermal Growth Factor Conditioned Medium Transform Growth Factor Hair Growth
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