Kinins as Neuropeptides

  • David C. Perry
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)


The kinins, including the nonapeptide bradykinin (BK) as well as several other peptide analogues of BK, have been known since their initial discovery (Rocha e Silva, 1949) to be highly active in a number of peripheral organ systems. The recent explosion of research on brain peptides has renewed interest in the possibility that kinins may also play roles as neuropeptides. In this chapter I review evidence that BK and other kinins may be acting as neuroactive peptides, especially in the central nervous system.


Pressor Response Mean Arterial Blood Pressure Tissue Kallikrein Sedation Phase Unanesthetized Rabbit 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • David C. Perry
    • 1
  1. 1.Department of PharmacologyGeorge Washington University Medical CenterUSA

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