Neuropeptides Modulate Carbachol-Stimulated “Boxing” Behavior in the Rat Medial Frontal Cortex

  • Jacqueline N. Crawley
  • Jill A. Stivers
  • David M. Jacobowitz
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)


The discovery of neuropeptides in mammalian brain was followed by the iconoclastic revelation that peptides coexist in the same neuron with classical neurotransmitters(Hökfelt et al., 1984). In 1983, coexistence of substance P (SP) and acetylcholin-esterase (AchE) or choline acetyltransferase (ChAt) was described in neurons of the nucleus tegmentalis dorsalis lateralis (NTDL) in rat brain (Vincent et al., 1983; Olschowka et al., 1983). Preliminary data suggested that some of the NTDL cells also contained corticotropin-releasing factor (CRF) (Olschowka et al., 1983). In addition, immunohistochemical studies have shown that SP- and CRF-containing cells in the NTDL project to the medial frontal cortex, lateral septum, and thalamus(Crawley et al., 1985a).


Lateral Septum Medial Frontal Cortex Stereotyped Motor Standard Anticonvulsant Drug Nicotinic Antagonist Mecamylamine 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Jacqueline N. Crawley
    • 1
  • Jill A. Stivers
    • 1
  • David M. Jacobowitz
    • 2
  1. 1.Clinical Neuroscience Branch, National Institute of Mental HealthNational Institutes of HealthBethesdaUSA
  2. 2.Laboratory of Clinical ScienceNational Institute of Mental Health, National Institutes of HealthBethesdaUSA

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