Effects of Cations and Nucleotides on Neurotensin Binding to Rat Brain Synaptic Membranes

  • Patrick Kitabgi
  • Jean-Pierre Vincent
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)


The tridecapeptide neurotensin (NT) (pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-OH) is thought to act as a neurotransmitter/modulator in the central nervous system (Nemeroff et al., 1982). The existence of functional specific NT receptors that exist in both high- and low-affinity states in brain tissues has been well documented (Kitabgi et al., 1985). In some cases, it has been possible to identify the neurons that bear NT receptors. For instance, there is strong evidence for the presence of somatodendritic NT receptors on dopaminergic neurons from the substantia nigra and the ventral tegmental area (Quirion, 1983). These receptors presumably mediate, at least in part, the regulatory effects that NT is thought to exert on the nigrostriatal and mesolimbic dopaminergic systems (Nemeroff and Cain, 1985).


Ventral Tegmental Area Synaptic Membrane Scatchard Analysis Neurotensin Receptor Mesolimbic Dopaminergic System 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Patrick Kitabgi
    • 1
  • Jean-Pierre Vincent
    • 1
  1. 1.Centre de Biochimie du CNRSFaculté des SciencesParc ValroseFrance

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