Calcitonin Gene-Related Peptide in the Central Nervous System

Neuronal and Receptor Localization Biochemical Characterization Functional Studies
  • David M. Jacobowitz
  • Gerhard Skofitsch
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)


Calcitonin gene-related peptide (CGRP) is a 37-amino-acid peptide that has been identified in rat brain and peripheral tissue by immunocytochemistry (Amara et al., 1982; Rosenfeld et al., 1983; Skofitsch and Jacobowitz, 1985c) and in the human brain by radioimmunoassay (Morris et al., 1984; Tschopp et al., 1984, 1985). It was isolated from human medullary thyroid carcinomas and sequenced (Morris et al., 1984). The initial immunocytochemical description of the localization of CGRP revealed a unique neuronal distribution in the CNS and periphery (Rosenfeld et al., 1984). A widespread distribution of immunoreactive cells and fibers was observed at all brain levels and in numerous peripheral organs.


Trigeminal Ganglion Insular Cortex Receptor Binding Site Medial Geniculate Body Central Amygdaloid Nucleus 


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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • David M. Jacobowitz
    • 1
  • Gerhard Skofitsch
    • 2
  1. 1.Clinical Neuroscience Branch, National Institute of Mental HealthNational Institutes of HealthBethesdaUSA
  2. 2.Laboratory of Clinical Science, National Institute of Mental HealthNational Institutes of HealthBethesdaUSA

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